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Gene: SLCO1A2 |
Gene summary for SLCO1A2 |
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Gene information | Species | Human | Gene symbol | SLCO1A2 | Gene ID | 6579 |
Gene name | solute carrier organic anion transporter family member 1A2 | |
Gene Alias | OATP | |
Cytomap | 12p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024RAT5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6579 | SLCO1A2 | C38 | Human | Oral cavity | OSCC | 1.66e-10 | 7.27e-01 | 0.172 |
6579 | SLCO1A2 | C06 | Human | Oral cavity | OSCC | 6.22e-04 | 4.95e-01 | 0.2699 |
6579 | SLCO1A2 | C08 | Human | Oral cavity | OSCC | 3.71e-12 | 2.26e-01 | 0.1919 |
6579 | SLCO1A2 | LN38 | Human | Oral cavity | OSCC | 1.18e-06 | 9.00e-01 | 0.168 |
6579 | SLCO1A2 | SYSMH1 | Human | Oral cavity | OSCC | 1.77e-03 | 8.17e-02 | 0.1127 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLCO1A2 | SNV | Missense_Mutation | rs766585974 | c.20N>T | p.Arg7Ile | p.R7I | P46721 | protein_coding | tolerated(0.2) | benign(0.067) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLCO1A2 | SNV | Missense_Mutation | c.1574N>A | p.Ser525Tyr | p.S525Y | P46721 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SLCO1A2 | SNV | Missense_Mutation | rs11568564 | c.502N>T | p.Arg168Cys | p.R168C | P46721 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-A02H-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
SLCO1A2 | SNV | Missense_Mutation | c.67N>G | p.Leu23Val | p.L23V | P46721 | protein_coding | deleterious(0.01) | possibly_damaging(0.718) | TCGA-CM-5868-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
SLCO1A2 | SNV | Missense_Mutation | rs376154842 | c.718C>T | p.Arg240Cys | p.R240C | P46721 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
SLCO1A2 | SNV | Missense_Mutation | c.1857N>G | p.Ile619Met | p.I619M | P46721 | protein_coding | deleterious(0.03) | benign(0.071) | TCGA-AG-3890-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLCO1A2 | SNV | Missense_Mutation | c.1243G>T | p.Val415Phe | p.V415F | P46721 | protein_coding | deleterious(0.01) | possibly_damaging(0.841) | TCGA-F5-6810-01 | Colorectum | rectum adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown | |
SLCO1A2 | insertion | Frame_Shift_Ins | novel | c.938_939insAA | p.Cys314ThrfsTer12 | p.C314Tfs*12 | P46721 | protein_coding | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
SLCO1A2 | insertion | Frame_Shift_Ins | novel | c.1211_1212insT | p.Leu404PhefsTer8 | p.L404Ffs*8 | P46721 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SLCO1A2 | deletion | Frame_Shift_Del | c.1345delN | p.Ile449TyrfsTer29 | p.I449Yfs*29 | P46721 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | TESTOSTERONE | TESTOSTERONE | 8779895 | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | inhibitor | 135652711 | RIFAMPIN | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | HORMONES | 8779894 | ||
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | hmg coa reductase inhibitors | |||
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | inhibitor | 178101291 | ||
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | rocuronium | ROCURONIUM | 28409297 | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | methotrexate | METHOTREXATE | 21317831 | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | 178101458 | |||
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | imatinib | IMATINIB | 21633340 | |
6579 | SLCO1A2 | TRANSPORTER, DRUGGABLE GENOME | 178101232 |
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