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Gene: SLC7A11 |
Gene summary for SLC7A11 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SLC7A11 | Gene ID | 23657 |
Gene name | solute carrier family 7 member 11 | |
Gene Alias | CCBR1 | |
Cytomap | 4q28.3 | |
Gene Type | protein-coding | GO ID | GO:0000096 | UniProtAcc | Q9UPY5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23657 | SLC7A11 | LZE2T | Human | Esophagus | ESCC | 6.62e-04 | 4.46e-01 | 0.082 |
23657 | SLC7A11 | LZE4T | Human | Esophagus | ESCC | 2.90e-39 | 1.43e+00 | 0.0811 |
23657 | SLC7A11 | LZE7T | Human | Esophagus | ESCC | 1.08e-14 | 8.50e-01 | 0.0667 |
23657 | SLC7A11 | P4T-E | Human | Esophagus | ESCC | 4.06e-07 | 2.60e-01 | 0.1323 |
23657 | SLC7A11 | P5T-E | Human | Esophagus | ESCC | 5.95e-06 | 1.46e-01 | 0.1327 |
23657 | SLC7A11 | P9T-E | Human | Esophagus | ESCC | 3.53e-24 | 6.74e-01 | 0.1131 |
23657 | SLC7A11 | P15T-E | Human | Esophagus | ESCC | 2.41e-35 | 8.29e-01 | 0.1149 |
23657 | SLC7A11 | P21T-E | Human | Esophagus | ESCC | 3.76e-24 | 6.73e-01 | 0.1617 |
23657 | SLC7A11 | P22T-E | Human | Esophagus | ESCC | 2.11e-06 | 1.71e-01 | 0.1236 |
23657 | SLC7A11 | P23T-E | Human | Esophagus | ESCC | 6.41e-03 | 1.81e-01 | 0.108 |
23657 | SLC7A11 | P26T-E | Human | Esophagus | ESCC | 2.28e-03 | 1.58e-01 | 0.1276 |
23657 | SLC7A11 | P28T-E | Human | Esophagus | ESCC | 7.22e-03 | 2.12e-01 | 0.1149 |
23657 | SLC7A11 | P30T-E | Human | Esophagus | ESCC | 6.64e-38 | 1.34e+00 | 0.137 |
23657 | SLC7A11 | P32T-E | Human | Esophagus | ESCC | 9.98e-39 | 1.23e+00 | 0.1666 |
23657 | SLC7A11 | P39T-E | Human | Esophagus | ESCC | 1.23e-09 | 3.23e-01 | 0.0894 |
23657 | SLC7A11 | P42T-E | Human | Esophagus | ESCC | 2.06e-13 | 7.62e-01 | 0.1175 |
23657 | SLC7A11 | P47T-E | Human | Esophagus | ESCC | 2.45e-02 | 1.31e-01 | 0.1067 |
23657 | SLC7A11 | P48T-E | Human | Esophagus | ESCC | 1.11e-03 | 2.67e-01 | 0.0959 |
23657 | SLC7A11 | P49T-E | Human | Esophagus | ESCC | 5.16e-18 | 2.44e+00 | 0.1768 |
23657 | SLC7A11 | P52T-E | Human | Esophagus | ESCC | 6.67e-12 | 4.06e-01 | 0.1555 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:190547519 | Esophagus | ESCC | regulation of protein localization to membrane | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:0002262111 | Esophagus | ESCC | myeloid cell homeostasis | 104/8552 | 157/18723 | 1.49e-07 | 2.36e-06 | 104 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:0048872111 | Esophagus | ESCC | homeostasis of number of cells | 163/8552 | 272/18723 | 1.40e-06 | 1.69e-05 | 163 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
GO:00303249 | Esophagus | ESCC | lung development | 109/8552 | 177/18723 | 1.40e-05 | 1.27e-04 | 109 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:00423986 | Esophagus | ESCC | cellular modified amino acid biosynthetic process | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421629 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0421638 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0421641 | Liver | HCC | Ferroptosis | 33/4020 | 41/8465 | 1.42e-05 | 9.88e-05 | 5.50e-05 | 33 |
hsa0421651 | Liver | HCC | Ferroptosis | 33/4020 | 41/8465 | 1.42e-05 | 9.88e-05 | 5.50e-05 | 33 |
hsa0421620 | Oral cavity | OSCC | Ferroptosis | 29/3704 | 41/8465 | 4.26e-04 | 1.30e-03 | 6.60e-04 | 29 |
hsa04216110 | Oral cavity | OSCC | Ferroptosis | 29/3704 | 41/8465 | 4.26e-04 | 1.30e-03 | 6.60e-04 | 29 |
hsa0421626 | Prostate | Tumor | Ferroptosis | 24/1791 | 41/8465 | 1.94e-07 | 2.14e-06 | 1.33e-06 | 24 |
hsa0421636 | Prostate | Tumor | Ferroptosis | 24/1791 | 41/8465 | 1.94e-07 | 2.14e-06 | 1.33e-06 | 24 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC7A11 | SNV | Missense_Mutation | rs763081007 | c.17N>C | p.Val6Ala | p.V6A | Q9UPY5 | protein_coding | tolerated_low_confidence(0.63) | benign(0) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | rs186693425 | c.653N>T | p.Thr218Met | p.T218M | Q9UPY5 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-D5-6920-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | rs771913516 | c.1388N>T | p.Ala463Val | p.A463V | Q9UPY5 | protein_coding | tolerated(1) | benign(0.005) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | rs554325259 | c.700N>T | p.Arg234Trp | p.R234W | Q9UPY5 | protein_coding | deleterious(0.01) | possibly_damaging(0.67) | TCGA-G4-6627-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLC7A11 | SNV | Missense_Mutation | rs757026554 | c.1396N>A | p.Leu466Ile | p.L466I | Q9UPY5 | protein_coding | tolerated(0.29) | benign(0.021) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | novel | c.224G>A | p.Ser75Asn | p.S75N | Q9UPY5 | protein_coding | tolerated(0.15) | benign(0.414) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLC7A11 | SNV | Missense_Mutation | novel | c.55A>C | p.Asn19His | p.N19H | Q9UPY5 | protein_coding | deleterious(0.04) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | novel | c.373G>A | p.Val125Ile | p.V125I | Q9UPY5 | protein_coding | tolerated(1) | benign(0.006) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | novel | c.386N>C | p.Val129Ala | p.V129A | Q9UPY5 | protein_coding | tolerated(0.78) | benign(0.02) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | novel | c.799N>A | p.Pro267Thr | p.P267T | Q9UPY5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23657 | SLC7A11 | TRANSPORTER, DRUGGABLE GENOME, CELL SURFACE | RILUZOLE | RILUZOLE | ||
23657 | SLC7A11 | TRANSPORTER, DRUGGABLE GENOME, CELL SURFACE | inhibitor | 135650876 | QUISQUALATE |
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