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Gene: SLC7A1 |
Gene summary for SLC7A1 |
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Gene information | Species | Human | Gene symbol | SLC7A1 | Gene ID | 6541 |
Gene name | solute carrier family 7 member 1 | |
Gene Alias | ATRC1 | |
Cytomap | 13q12.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024RDQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6541 | SLC7A1 | CA_HPV_3 | Human | Cervix | CC | 7.43e-05 | 1.83e-01 | 0.0414 |
6541 | SLC7A1 | CCI_2 | Human | Cervix | CC | 2.13e-04 | 7.89e-01 | 0.5249 |
6541 | SLC7A1 | CCI_3 | Human | Cervix | CC | 1.41e-11 | 1.25e+00 | 0.516 |
6541 | SLC7A1 | AEH-subject1 | Human | Endometrium | AEH | 8.33e-25 | 6.44e-01 | -0.3059 |
6541 | SLC7A1 | AEH-subject2 | Human | Endometrium | AEH | 3.67e-02 | 2.71e-01 | -0.2525 |
6541 | SLC7A1 | AEH-subject5 | Human | Endometrium | AEH | 2.36e-38 | 9.14e-01 | -0.2953 |
6541 | SLC7A1 | EEC-subject1 | Human | Endometrium | EEC | 1.98e-22 | 6.54e-01 | -0.2682 |
6541 | SLC7A1 | EEC-subject2 | Human | Endometrium | EEC | 5.49e-03 | 2.83e-01 | -0.2607 |
6541 | SLC7A1 | EEC-subject4 | Human | Endometrium | EEC | 7.37e-19 | 6.37e-01 | -0.2571 |
6541 | SLC7A1 | EEC-subject5 | Human | Endometrium | EEC | 4.19e-10 | 4.44e-01 | -0.249 |
6541 | SLC7A1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.80e-06 | 1.34e-01 | -0.1869 |
6541 | SLC7A1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 5.99e-05 | -2.10e-02 | -0.1883 |
6541 | SLC7A1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.91e-02 | 8.72e-02 | -0.1934 |
6541 | SLC7A1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.90e-08 | 7.32e-02 | -0.1917 |
6541 | SLC7A1 | LZE4T | Human | Esophagus | ESCC | 3.74e-10 | -1.92e-01 | 0.0811 |
6541 | SLC7A1 | LZE8T | Human | Esophagus | ESCC | 3.32e-04 | -1.78e-01 | 0.067 |
6541 | SLC7A1 | LZE20T | Human | Esophagus | ESCC | 4.52e-04 | -2.89e-01 | 0.0662 |
6541 | SLC7A1 | LZE24T | Human | Esophagus | ESCC | 6.26e-08 | 1.97e-02 | 0.0596 |
6541 | SLC7A1 | P2T-E | Human | Esophagus | ESCC | 6.00e-13 | 1.54e-01 | 0.1177 |
6541 | SLC7A1 | P4T-E | Human | Esophagus | ESCC | 9.48e-18 | 2.10e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
GO:00420988 | Cervix | CC | T cell proliferation | 49/2311 | 199/18723 | 1.32e-06 | 4.49e-05 | 49 |
GO:00421297 | Cervix | CC | regulation of T cell proliferation | 43/2311 | 171/18723 | 3.21e-06 | 8.77e-05 | 43 |
GO:00706637 | Cervix | CC | regulation of leukocyte proliferation | 55/2311 | 245/18723 | 6.51e-06 | 1.56e-04 | 55 |
GO:00224099 | Cervix | CC | positive regulation of cell-cell adhesion | 61/2311 | 284/18723 | 9.30e-06 | 2.11e-04 | 61 |
GO:00506705 | Cervix | CC | regulation of lymphocyte proliferation | 51/2311 | 225/18723 | 1.05e-05 | 2.32e-04 | 51 |
GO:00329444 | Cervix | CC | regulation of mononuclear cell proliferation | 51/2311 | 227/18723 | 1.36e-05 | 2.73e-04 | 51 |
GO:19030397 | Cervix | CC | positive regulation of leukocyte cell-cell adhesion | 53/2311 | 239/18723 | 1.37e-05 | 2.74e-04 | 53 |
GO:00508708 | Cervix | CC | positive regulation of T cell activation | 49/2311 | 216/18723 | 1.51e-05 | 2.97e-04 | 49 |
GO:00706617 | Cervix | CC | leukocyte proliferation | 65/2311 | 318/18723 | 2.56e-05 | 4.32e-04 | 65 |
GO:00466516 | Cervix | CC | lymphocyte proliferation | 59/2311 | 288/18723 | 5.53e-05 | 8.10e-04 | 59 |
GO:00329435 | Cervix | CC | mononuclear cell proliferation | 59/2311 | 291/18723 | 7.51e-05 | 1.03e-03 | 59 |
GO:00026967 | Cervix | CC | positive regulation of leukocyte activation | 72/2311 | 409/18723 | 1.13e-03 | 9.31e-03 | 72 |
GO:00512516 | Cervix | CC | positive regulation of lymphocyte activation | 65/2311 | 362/18723 | 1.15e-03 | 9.39e-03 | 65 |
GO:00508676 | Cervix | CC | positive regulation of cell activation | 73/2311 | 420/18723 | 1.50e-03 | 1.16e-02 | 73 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC7A1 | SNV | Missense_Mutation | c.337N>G | p.Thr113Ala | p.T113A | P30825 | protein_coding | tolerated(0.14) | possibly_damaging(0.776) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLC7A1 | SNV | Missense_Mutation | c.779C>T | p.Ala260Val | p.A260V | P30825 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A6-6137-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
SLC7A1 | SNV | Missense_Mutation | novel | c.1501A>G | p.Ser501Gly | p.S501G | P30825 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC7A1 | SNV | Missense_Mutation | c.46N>T | p.Arg16Trp | p.R16W | P30825 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC7A1 | SNV | Missense_Mutation | c.400G>A | p.Ala134Thr | p.A134T | P30825 | protein_coding | tolerated(0.1) | probably_damaging(0.975) | TCGA-AD-6965-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD | |
SLC7A1 | SNV | Missense_Mutation | c.386C>T | p.Ala129Val | p.A129V | P30825 | protein_coding | deleterious(0.03) | probably_damaging(0.98) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC7A1 | SNV | Missense_Mutation | rs138868586 | c.1262C>T | p.Ser421Leu | p.S421L | P30825 | protein_coding | deleterious(0.02) | probably_damaging(0.941) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLC7A1 | SNV | Missense_Mutation | c.221N>T | p.Ala74Val | p.A74V | P30825 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC7A1 | deletion | Frame_Shift_Del | novel | c.372_373delTA | p.Thr125PhefsTer37 | p.T125Ffs*37 | P30825 | protein_coding | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | ||
SLC7A1 | deletion | Frame_Shift_Del | c.861delN | p.Val288TrpfsTer8 | p.V288Wfs*8 | P30825 | protein_coding | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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