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Gene: SLC6A15 |
Gene summary for SLC6A15 |
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Gene information | Species | Human | Gene symbol | SLC6A15 | Gene ID | 55117 |
Gene name | solute carrier family 6 member 15 | |
Gene Alias | NTT73 | |
Cytomap | 12q21.31 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | Q8IXG2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55117 | SLC6A15 | P2T-E | Human | Esophagus | ESCC | 1.33e-21 | 4.51e-01 | 0.1177 |
55117 | SLC6A15 | P5T-E | Human | Esophagus | ESCC | 2.86e-05 | 3.19e-02 | 0.1327 |
55117 | SLC6A15 | P10T-E | Human | Esophagus | ESCC | 1.75e-04 | 4.77e-02 | 0.116 |
55117 | SLC6A15 | P12T-E | Human | Esophagus | ESCC | 5.12e-04 | 1.99e-02 | 0.1122 |
55117 | SLC6A15 | P16T-E | Human | Esophagus | ESCC | 3.26e-54 | 9.89e-01 | 0.1153 |
55117 | SLC6A15 | P20T-E | Human | Esophagus | ESCC | 5.28e-10 | 7.63e-02 | 0.1124 |
55117 | SLC6A15 | P26T-E | Human | Esophagus | ESCC | 4.58e-12 | 2.37e-01 | 0.1276 |
55117 | SLC6A15 | P27T-E | Human | Esophagus | ESCC | 2.34e-02 | 3.94e-02 | 0.1055 |
55117 | SLC6A15 | P32T-E | Human | Esophagus | ESCC | 3.81e-12 | 2.40e-01 | 0.1666 |
55117 | SLC6A15 | P37T-E | Human | Esophagus | ESCC | 1.37e-10 | 3.02e-01 | 0.1371 |
55117 | SLC6A15 | P54T-E | Human | Esophagus | ESCC | 1.94e-13 | 2.93e-01 | 0.0975 |
55117 | SLC6A15 | P56T-E | Human | Esophagus | ESCC | 4.74e-06 | 8.16e-01 | 0.1613 |
55117 | SLC6A15 | P62T-E | Human | Esophagus | ESCC | 2.99e-03 | 1.49e-01 | 0.1302 |
55117 | SLC6A15 | P65T-E | Human | Esophagus | ESCC | 4.47e-03 | -3.21e-02 | 0.0978 |
55117 | SLC6A15 | P74T-E | Human | Esophagus | ESCC | 1.10e-03 | 1.18e-01 | 0.1479 |
55117 | SLC6A15 | P76T-E | Human | Esophagus | ESCC | 2.59e-03 | 1.21e-01 | 0.1207 |
55117 | SLC6A15 | P83T-E | Human | Esophagus | ESCC | 1.03e-09 | 3.57e-01 | 0.1738 |
55117 | SLC6A15 | P89T-E | Human | Esophagus | ESCC | 2.69e-06 | 8.37e-01 | 0.1752 |
55117 | SLC6A15 | P91T-E | Human | Esophagus | ESCC | 1.72e-05 | 9.24e-01 | 0.1828 |
55117 | SLC6A15 | P107T-E | Human | Esophagus | ESCC | 1.38e-19 | 4.92e-01 | 0.171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC6A15 | SNV | Missense_Mutation | rs759917281 | c.1919N>A | p.Arg640His | p.R640H | Q9H2J7 | protein_coding | deleterious(0.02) | benign(0.033) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD |
SLC6A15 | SNV | Missense_Mutation | c.64N>T | p.Asp22Tyr | p.D22Y | Q9H2J7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC6A15 | SNV | Missense_Mutation | c.1684N>A | p.Gly562Ser | p.G562S | Q9H2J7 | protein_coding | deleterious(0.02) | probably_damaging(0.986) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR | |
SLC6A15 | SNV | Missense_Mutation | c.994T>A | p.Phe332Ile | p.F332I | Q9H2J7 | protein_coding | tolerated(0.1) | probably_damaging(0.992) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC6A15 | SNV | Missense_Mutation | rs139565834 | c.848N>A | p.Arg283His | p.R283H | Q9H2J7 | protein_coding | tolerated(0.13) | benign(0.013) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLC6A15 | SNV | Missense_Mutation | novel | c.1909N>G | p.Phe637Val | p.F637V | Q9H2J7 | protein_coding | deleterious(0.01) | benign(0.278) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC6A15 | SNV | Missense_Mutation | c.602N>A | p.Ser201Tyr | p.S201Y | Q9H2J7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SLC6A15 | SNV | Missense_Mutation | c.262N>A | p.Pro88Thr | p.P88T | Q9H2J7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SLC6A15 | SNV | Missense_Mutation | rs776447756 | c.95A>G | p.Asp32Gly | p.D32G | Q9H2J7 | protein_coding | tolerated(0.15) | benign(0.056) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
SLC6A15 | SNV | Missense_Mutation | c.1874N>C | p.Leu625Pro | p.L625P | Q9H2J7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CK-4952-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55117 | SLC6A15 | DRUGGABLE GENOME, TRANSPORTER | inhibitor | 178103791 | LORATADINE | |
55117 | SLC6A15 | DRUGGABLE GENOME, TRANSPORTER | LORATADINE | LORATADINE | 25318072 |
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