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Gene: SLC52A1 |
Gene summary for SLC52A1 |
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Gene information | Species | Human | Gene symbol | SLC52A1 | Gene ID | 55065 |
Gene name | solute carrier family 52 member 1 | |
Gene Alias | GPCR42 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006766 | UniProtAcc | Q9NWF4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55065 | SLC52A1 | ATC13 | Human | Thyroid | ATC | 2.12e-37 | 6.29e-01 | 0.34 |
55065 | SLC52A1 | ATC5 | Human | Thyroid | ATC | 5.57e-37 | 6.62e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603234 | Thyroid | ATC | viral process | 241/6293 | 415/18723 | 5.50e-25 | 2.04e-22 | 241 |
GO:001905835 | Thyroid | ATC | viral life cycle | 173/6293 | 317/18723 | 9.22e-15 | 5.50e-13 | 173 |
GO:004440334 | Thyroid | ATC | biological process involved in symbiotic interaction | 153/6293 | 290/18723 | 1.12e-11 | 4.12e-10 | 153 |
GO:005170134 | Thyroid | ATC | biological process involved in interaction with host | 112/6293 | 203/18723 | 1.93e-10 | 5.76e-09 | 112 |
GO:005212633 | Thyroid | ATC | movement in host environment | 94/6293 | 175/18723 | 3.20e-08 | 6.00e-07 | 94 |
GO:004440933 | Thyroid | ATC | entry into host | 76/6293 | 151/18723 | 1.54e-05 | 1.43e-04 | 76 |
GO:004671833 | Thyroid | ATC | viral entry into host cell | 72/6293 | 144/18723 | 3.38e-05 | 2.80e-04 | 72 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC52A1 | SNV | Missense_Mutation | c.910N>C | p.Ser304Pro | p.S304P | Q9NWF4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC52A1 | SNV | Missense_Mutation | rs769783510 | c.1270N>A | p.Gly424Ser | p.G424S | Q9NWF4 | protein_coding | tolerated(0.05) | benign(0.02) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC52A1 | SNV | Missense_Mutation | c.1138C>A | p.Leu380Met | p.L380M | Q9NWF4 | protein_coding | deleterious(0.04) | possibly_damaging(0.621) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
SLC52A1 | SNV | Missense_Mutation | c.457C>T | p.Leu153Phe | p.L153F | Q9NWF4 | protein_coding | tolerated(0.1) | possibly_damaging(0.455) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
SLC52A1 | SNV | Missense_Mutation | novel | c.1183N>A | p.Ala395Thr | p.A395T | Q9NWF4 | protein_coding | tolerated(0.29) | benign(0.115) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC52A1 | SNV | Missense_Mutation | novel | c.131N>A | p.Gly44Asp | p.G44D | Q9NWF4 | protein_coding | deleterious(0) | possibly_damaging(0.655) | TCGA-AP-A1DR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
SLC52A1 | SNV | Missense_Mutation | c.691C>T | p.Pro231Ser | p.P231S | Q9NWF4 | protein_coding | tolerated(0.49) | benign(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |
SLC52A1 | SNV | Missense_Mutation | novel | c.44N>C | p.Leu15Pro | p.L15P | Q9NWF4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC52A1 | SNV | Missense_Mutation | rs201477941 | c.23N>A | p.Arg8His | p.R8H | Q9NWF4 | protein_coding | tolerated(0.18) | possibly_damaging(0.72) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC52A1 | SNV | Missense_Mutation | rs139373407 | c.628G>A | p.Ala210Thr | p.A210T | Q9NWF4 | protein_coding | deleterious(0) | possibly_damaging(0.738) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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