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Gene: SLC35E4 |
Gene summary for SLC35E4 |
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Gene information | Species | Human | Gene symbol | SLC35E4 | Gene ID | 339665 |
Gene name | solute carrier family 35 member E4 | |
Gene Alias | SLC35E4 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6ICL7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339665 | SLC35E4 | LZE4T | Human | Esophagus | ESCC | 3.18e-05 | 1.52e-01 | 0.0811 |
339665 | SLC35E4 | P10T-E | Human | Esophagus | ESCC | 3.64e-04 | 8.76e-02 | 0.116 |
339665 | SLC35E4 | P11T-E | Human | Esophagus | ESCC | 6.74e-09 | 3.25e-01 | 0.1426 |
339665 | SLC35E4 | P12T-E | Human | Esophagus | ESCC | 2.46e-05 | 1.52e-01 | 0.1122 |
339665 | SLC35E4 | P15T-E | Human | Esophagus | ESCC | 8.45e-06 | 1.59e-01 | 0.1149 |
339665 | SLC35E4 | P16T-E | Human | Esophagus | ESCC | 1.31e-04 | 9.87e-02 | 0.1153 |
339665 | SLC35E4 | P20T-E | Human | Esophagus | ESCC | 5.73e-03 | 9.77e-02 | 0.1124 |
339665 | SLC35E4 | P21T-E | Human | Esophagus | ESCC | 1.73e-08 | 2.37e-01 | 0.1617 |
339665 | SLC35E4 | P22T-E | Human | Esophagus | ESCC | 3.48e-02 | 1.05e-01 | 0.1236 |
339665 | SLC35E4 | P26T-E | Human | Esophagus | ESCC | 1.27e-06 | 1.87e-01 | 0.1276 |
339665 | SLC35E4 | P27T-E | Human | Esophagus | ESCC | 1.67e-02 | 9.45e-02 | 0.1055 |
339665 | SLC35E4 | P28T-E | Human | Esophagus | ESCC | 1.83e-09 | 2.25e-01 | 0.1149 |
339665 | SLC35E4 | P30T-E | Human | Esophagus | ESCC | 1.72e-15 | 4.73e-01 | 0.137 |
339665 | SLC35E4 | P31T-E | Human | Esophagus | ESCC | 1.11e-02 | 1.20e-01 | 0.1251 |
339665 | SLC35E4 | P32T-E | Human | Esophagus | ESCC | 1.29e-07 | 1.74e-01 | 0.1666 |
339665 | SLC35E4 | P36T-E | Human | Esophagus | ESCC | 5.72e-04 | 1.59e-01 | 0.1187 |
339665 | SLC35E4 | P37T-E | Human | Esophagus | ESCC | 1.87e-02 | 8.75e-02 | 0.1371 |
339665 | SLC35E4 | P40T-E | Human | Esophagus | ESCC | 2.37e-02 | 1.00e-01 | 0.109 |
339665 | SLC35E4 | P42T-E | Human | Esophagus | ESCC | 2.62e-05 | 1.50e-01 | 0.1175 |
339665 | SLC35E4 | P47T-E | Human | Esophagus | ESCC | 1.73e-02 | 8.78e-02 | 0.1067 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35E4 | SNV | Missense_Mutation | rs372345536 | c.946G>A | p.Ala316Thr | p.A316T | Q6ICL7 | protein_coding | tolerated(0.09) | benign(0.005) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLC35E4 | SNV | Missense_Mutation | c.328G>A | p.Val110Ile | p.V110I | Q6ICL7 | protein_coding | tolerated(0.3) | benign(0.031) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC35E4 | SNV | Missense_Mutation | novel | c.989T>C | p.Phe330Ser | p.F330S | Q6ICL7 | protein_coding | tolerated(0.22) | benign(0) | TCGA-EY-A1GD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35E4 | SNV | Missense_Mutation | novel | c.392T>C | p.Val131Ala | p.V131A | Q6ICL7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35E4 | SNV | Missense_Mutation | c.329N>C | p.Val110Ala | p.V110A | Q6ICL7 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
SLC35E4 | SNV | Missense_Mutation | novel | c.896N>T | p.Ser299Phe | p.S299F | Q6ICL7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLC35E4 | deletion | Frame_Shift_Del | novel | c.100delN | p.Pro35LeufsTer94 | p.P35Lfs*94 | Q6ICL7 | protein_coding | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC35E4 | SNV | Missense_Mutation | rs755179385 | c.758N>A | p.Arg253His | p.R253H | Q6ICL7 | protein_coding | tolerated(0.65) | benign(0.005) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLC35E4 | SNV | Missense_Mutation | c.406N>C | p.Ala136Pro | p.A136P | Q6ICL7 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-05-4430-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC35E4 | SNV | Missense_Mutation | novel | c.223N>T | p.Gly75Cys | p.G75C | Q6ICL7 | protein_coding | deleterious(0) | possibly_damaging(0.648) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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