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Gene: SLC35D1 |
Gene summary for SLC35D1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SLC35D1 | Gene ID | 23169 |
Gene name | solute carrier family 35 member D1 | |
Gene Alias | SHNKND | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NTN3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23169 | SLC35D1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.85e-15 | -5.56e-01 | 0.0155 |
23169 | SLC35D1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.93e-03 | -4.28e-01 | -0.1207 |
23169 | SLC35D1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.00e-07 | -3.88e-01 | -0.1001 |
23169 | SLC35D1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.64e-11 | -5.44e-01 | 0.096 |
23169 | SLC35D1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.22e-09 | -4.12e-01 | 0.0674 |
23169 | SLC35D1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.30e-13 | -4.76e-01 | 0.294 |
23169 | SLC35D1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.74e-03 | -4.61e-01 | 0.281 |
23169 | SLC35D1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.86e-03 | -3.30e-01 | 0.3859 |
23169 | SLC35D1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.53e-08 | -6.58e-01 | 0.2585 |
23169 | SLC35D1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.40e-17 | -5.16e-01 | 0.3005 |
23169 | SLC35D1 | A002-C-010 | Human | Colorectum | FAP | 9.51e-03 | -2.09e-01 | 0.242 |
23169 | SLC35D1 | A015-C-203 | Human | Colorectum | FAP | 1.45e-27 | -4.30e-01 | -0.1294 |
23169 | SLC35D1 | A015-C-204 | Human | Colorectum | FAP | 8.13e-07 | -2.76e-01 | -0.0228 |
23169 | SLC35D1 | A014-C-040 | Human | Colorectum | FAP | 8.77e-03 | -3.18e-01 | -0.1184 |
23169 | SLC35D1 | A002-C-201 | Human | Colorectum | FAP | 7.56e-13 | -3.44e-01 | 0.0324 |
23169 | SLC35D1 | A002-C-203 | Human | Colorectum | FAP | 7.03e-05 | -1.39e-01 | 0.2786 |
23169 | SLC35D1 | A001-C-119 | Human | Colorectum | FAP | 8.40e-12 | -5.11e-01 | -0.1557 |
23169 | SLC35D1 | A001-C-108 | Human | Colorectum | FAP | 6.57e-16 | -2.93e-01 | -0.0272 |
23169 | SLC35D1 | A002-C-205 | Human | Colorectum | FAP | 1.32e-21 | -4.62e-01 | -0.1236 |
23169 | SLC35D1 | A001-C-104 | Human | Colorectum | FAP | 3.59e-03 | -2.18e-01 | 0.0184 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:00159312 | Colorectum | MSS | nucleobase-containing compound transport | 70/3467 | 222/18723 | 1.92e-06 | 6.01e-05 | 70 |
GO:00159314 | Colorectum | FAP | nucleobase-containing compound transport | 45/2622 | 222/18723 | 6.22e-03 | 3.90e-02 | 45 |
GO:001593111 | Liver | HCC | nucleobase-containing compound transport | 150/7958 | 222/18723 | 3.17e-14 | 2.03e-12 | 150 |
GO:1901264 | Liver | HCC | carbohydrate derivative transport | 48/7958 | 80/18723 | 1.19e-03 | 6.62e-03 | 48 |
GO:0008643 | Liver | HCC | carbohydrate transport | 80/7958 | 152/18723 | 7.34e-03 | 2.92e-02 | 80 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35D1 | SNV | Missense_Mutation | rs776653054 | c.716G>A | p.Gly239Glu | p.G239E | Q9NTN3 | protein_coding | deleterious(0.02) | probably_damaging(0.927) | TCGA-D1-A1O0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC35D1 | SNV | Missense_Mutation | novel | c.1043N>C | p.Asp348Ala | p.D348A | Q9NTN3 | protein_coding | deleterious(0.03) | benign(0.079) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC35D1 | SNV | Missense_Mutation | c.614N>C | p.Val205Ala | p.V205A | Q9NTN3 | protein_coding | deleterious(0.03) | benign(0.158) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC35D1 | SNV | Missense_Mutation | novel | c.298N>A | p.Asp100Asn | p.D100N | Q9NTN3 | protein_coding | tolerated(0.13) | benign(0.033) | TCGA-G3-AAV0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC35D1 | SNV | Missense_Mutation | c.379N>G | p.Thr127Ala | p.T127A | Q9NTN3 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-J2-A4AG-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC35D1 | SNV | Missense_Mutation | c.44N>T | p.Glu15Val | p.E15V | Q9NTN3 | protein_coding | tolerated_low_confidence(0.23) | benign(0.011) | TCGA-MP-A4TE-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SLC35D1 | SNV | Missense_Mutation | c.847N>G | p.Leu283Val | p.L283V | Q9NTN3 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC35D1 | SNV | Missense_Mutation | novel | c.240G>A | p.Met80Ile | p.M80I | Q9NTN3 | protein_coding | deleterious(0.04) | benign(0.298) | TCGA-CN-6988-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC35D1 | SNV | Missense_Mutation | novel | c.749N>T | p.Trp250Leu | p.W250L | Q9NTN3 | protein_coding | deleterious(0.04) | possibly_damaging(0.68) | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD |
SLC35D1 | SNV | Missense_Mutation | novel | c.749N>T | p.Trp250Leu | p.W250L | Q9NTN3 | protein_coding | deleterious(0.04) | possibly_damaging(0.68) | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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