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Gene: SLC22A31 |
Gene summary for SLC22A31 |
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Gene information | Species | Human | Gene symbol | SLC22A31 | Gene ID | 146429 |
Gene name | solute carrier family 22 member 31 | |
Gene Alias | SLC22A31 | |
Cytomap | 16q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146429 | SLC22A31 | TD9 | Human | Lung | IAC | 2.44e-07 | 6.35e-01 | 0.088 |
146429 | SLC22A31 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 2.70e-02 | 6.76e-01 | -0.1406 |
146429 | SLC22A31 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 2.01e-03 | 6.18e-01 | -0.1408 |
146429 | SLC22A31 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 5.75e-05 | 9.58e-01 | -0.138 |
146429 | SLC22A31 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 7.46e-15 | 5.60e-01 | -0.2116 |
146429 | SLC22A31 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.01e-05 | 4.60e-01 | -0.1941 |
146429 | SLC22A31 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.17e-05 | 4.02e-01 | -0.2107 |
146429 | SLC22A31 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.23e-08 | 4.85e-01 | -0.2119 |
146429 | SLC22A31 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.98e-05 | 8.95e-02 | -0.0166 |
146429 | SLC22A31 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.37e-08 | 1.68e-01 | -0.0132 |
146429 | SLC22A31 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 9.27e-09 | 9.45e-02 | -0.013 |
146429 | SLC22A31 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 2.56e-06 | 9.21e-02 | -0.0121 |
146429 | SLC22A31 | RNA-P8T2-P8T2-3 | Human | Lung | AIS | 9.01e-04 | 7.40e-01 | -0.1284 |
146429 | SLC22A31 | male-WTA | Human | Thyroid | PTC | 5.37e-18 | 2.45e-01 | 0.1037 |
146429 | SLC22A31 | female-WTA | Human | Thyroid | PTC | 2.08e-02 | 2.53e-01 | 0.0726 |
146429 | SLC22A31 | PTC01 | Human | Thyroid | PTC | 4.60e-30 | 6.56e-01 | 0.1899 |
146429 | SLC22A31 | PTC03 | Human | Thyroid | PTC | 9.50e-07 | 2.71e-01 | 0.1784 |
146429 | SLC22A31 | PTC04 | Human | Thyroid | PTC | 6.62e-35 | 6.64e-01 | 0.1927 |
146429 | SLC22A31 | PTC05 | Human | Thyroid | PTC | 1.60e-40 | 1.37e+00 | 0.2065 |
146429 | SLC22A31 | PTC06 | Human | Thyroid | PTC | 5.43e-72 | 1.47e+00 | 0.2057 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC22A31 | SNV | Missense_Mutation | novel | c.150N>T | p.Glu50Asp | p.E50D | protein_coding | deleterious(0.01) | probably_damaging(0.915) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC22A31 | SNV | Missense_Mutation | rs755196390 | c.338N>A | p.Arg113His | p.R113H | protein_coding | tolerated(1) | benign(0) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC22A31 | SNV | Missense_Mutation | novel | c.250N>G | p.Leu84Val | p.L84V | protein_coding | tolerated(0.49) | benign(0.138) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC22A31 | SNV | Missense_Mutation | novel | c.73N>A | p.Arg25Ser | p.R25S | protein_coding | deleterious(0.04) | possibly_damaging(0.7) | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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