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Gene: SIK3 |
Gene summary for SIK3 |
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Gene information | Species | Human | Gene symbol | SIK3 | Gene ID | 23387 |
Gene name | SIK family kinase 3 | |
Gene Alias | L19 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A1A5A9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23387 | SIK3 | CCI_1 | Human | Cervix | CC | 9.92e-12 | 1.04e+00 | 0.528 |
23387 | SIK3 | CCI_2 | Human | Cervix | CC | 2.41e-13 | 1.49e+00 | 0.5249 |
23387 | SIK3 | CCI_3 | Human | Cervix | CC | 2.88e-17 | 9.73e-01 | 0.516 |
23387 | SIK3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.06e-34 | -8.63e-01 | 0.0155 |
23387 | SIK3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.36e-04 | -5.38e-01 | -0.1808 |
23387 | SIK3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.14e-02 | -4.51e-01 | -0.0811 |
23387 | SIK3 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.65e-04 | -5.20e-01 | -0.1088 |
23387 | SIK3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.80e-08 | -6.43e-01 | -0.1207 |
23387 | SIK3 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.16e-06 | -3.72e-01 | -0.1464 |
23387 | SIK3 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.85e-09 | -4.58e-01 | -0.1001 |
23387 | SIK3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.13e-02 | -5.42e-01 | -0.1706 |
23387 | SIK3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.40e-10 | -7.23e-01 | -0.2061 |
23387 | SIK3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.94e-08 | -5.58e-01 | -0.0179 |
23387 | SIK3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.18e-19 | -8.00e-01 | 0.096 |
23387 | SIK3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.98e-02 | -8.23e-01 | 0.0451 |
23387 | SIK3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.75e-05 | -6.50e-01 | 0.0528 |
23387 | SIK3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.49e-20 | -6.49e-01 | 0.0674 |
23387 | SIK3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.16e-04 | -4.50e-01 | 0.0112 |
23387 | SIK3 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.15e-05 | -6.57e-01 | 0.0397 |
23387 | SIK3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.42e-08 | -7.24e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031929 | Colorectum | MSS | TOR signaling | 35/3467 | 126/18723 | 6.91e-03 | 4.44e-02 | 35 |
GO:00319292 | Liver | Cirrhotic | TOR signaling | 44/4634 | 126/18723 | 6.69e-03 | 3.30e-02 | 44 |
GO:00319291 | Liver | HCC | TOR signaling | 78/7958 | 126/18723 | 8.49e-06 | 9.97e-05 | 78 |
GO:0032006 | Liver | HCC | regulation of TOR signaling | 63/7958 | 104/18723 | 1.50e-04 | 1.20e-03 | 63 |
GO:0032008 | Liver | HCC | positive regulation of TOR signaling | 31/7958 | 47/18723 | 9.90e-04 | 5.71e-03 | 31 |
GO:1904263 | Liver | HCC | positive regulation of TORC1 signaling | 14/7958 | 20/18723 | 1.21e-02 | 4.41e-02 | 14 |
GO:00319293 | Oral cavity | OSCC | TOR signaling | 67/7305 | 126/18723 | 8.52e-04 | 4.50e-03 | 67 |
GO:0038203 | Oral cavity | OSCC | TORC2 signaling | 10/7305 | 12/18723 | 2.25e-03 | 1.00e-02 | 10 |
GO:00320081 | Oral cavity | OSCC | positive regulation of TOR signaling | 28/7305 | 47/18723 | 3.41e-03 | 1.45e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIK3 | SNV | Missense_Mutation | c.1907N>G | p.Lys636Arg | p.K636R | protein_coding | tolerated_low_confidence(0.15) | probably_damaging(0.998) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SIK3 | SNV | Missense_Mutation | c.547N>T | p.Asn183Tyr | p.N183Y | protein_coding | deleterious(0.03) | probably_damaging(0.988) | TCGA-AA-3502-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SIK3 | SNV | Missense_Mutation | c.427G>A | p.Glu143Lys | p.E143K | protein_coding | deleterious(0) | benign(0.204) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SIK3 | SNV | Missense_Mutation | novel | c.1289T>C | p.Leu430Pro | p.L430P | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIK3 | SNV | Missense_Mutation | c.533T>G | p.Phe178Cys | p.F178C | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
SIK3 | SNV | Missense_Mutation | novel | c.3779N>T | p.Ser1260Ile | p.S1260I | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SIK3 | SNV | Missense_Mutation | c.2573N>G | p.His858Arg | p.H858R | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SIK3 | SNV | Missense_Mutation | novel | c.554N>G | p.Val185Gly | p.V185G | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
SIK3 | SNV | Missense_Mutation | rs150218961 | c.3772A>G | p.Met1258Val | p.M1258V | protein_coding | deleterious_low_confidence(0.02) | benign(0.138) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SIK3 | SNV | Missense_Mutation | rs769106443 | c.3011N>G | p.Gln1004Arg | p.Q1004R | protein_coding | tolerated_low_confidence(0.99) | benign(0.012) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23387 | SIK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 178102336 | BOSUTINIB | |
23387 | SIK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 340590212 | ||
23387 | SIK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 178102305 | DASATINIB | |
23387 | SIK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565729 |
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