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Gene: SIGLEC15 |
Gene summary for SIGLEC15 |
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Gene information | Species | Human | Gene symbol | SIGLEC15 | Gene ID | 284266 |
Gene name | sialic acid binding Ig like lectin 15 | |
Gene Alias | CD33L3 | |
Cytomap | 18q12.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q6ZMC9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284266 | SIGLEC15 | PTC01 | Human | Thyroid | PTC | 1.09e-02 | 1.01e-01 | 0.1899 |
284266 | SIGLEC15 | PTC04 | Human | Thyroid | PTC | 2.29e-02 | 7.47e-02 | 0.1927 |
284266 | SIGLEC15 | PTC06 | Human | Thyroid | PTC | 1.69e-04 | 1.53e-01 | 0.2057 |
284266 | SIGLEC15 | PTC07 | Human | Thyroid | PTC | 2.74e-06 | 1.85e-01 | 0.2044 |
284266 | SIGLEC15 | ATC09 | Human | Thyroid | ATC | 8.38e-13 | 5.59e-01 | 0.2871 |
284266 | SIGLEC15 | ATC12 | Human | Thyroid | ATC | 2.61e-10 | 3.18e-01 | 0.34 |
284266 | SIGLEC15 | ATC1 | Human | Thyroid | ATC | 1.33e-13 | 6.39e-01 | 0.2878 |
284266 | SIGLEC15 | ATC4 | Human | Thyroid | ATC | 3.02e-16 | 4.30e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032956113 | Thyroid | PTC | regulation of actin cytoskeleton organization | 182/5968 | 358/18723 | 4.64e-14 | 2.79e-12 | 182 |
GO:0032970113 | Thyroid | PTC | regulation of actin filament-based process | 197/5968 | 397/18723 | 8.91e-14 | 4.89e-12 | 197 |
GO:0030099113 | Thyroid | PTC | myeloid cell differentiation | 160/5968 | 381/18723 | 1.75e-05 | 1.82e-04 | 160 |
GO:00603486 | Thyroid | PTC | bone development | 90/5968 | 205/18723 | 1.89e-04 | 1.42e-03 | 90 |
GO:0032970210 | Thyroid | ATC | regulation of actin filament-based process | 208/6293 | 397/18723 | 5.82e-15 | 3.80e-13 | 208 |
GO:0032956210 | Thyroid | ATC | regulation of actin cytoskeleton organization | 190/6293 | 358/18723 | 1.73e-14 | 1.01e-12 | 190 |
GO:006034813 | Thyroid | ATC | bone development | 102/6293 | 205/18723 | 1.18e-06 | 1.52e-05 | 102 |
GO:003009933 | Thyroid | ATC | myeloid cell differentiation | 170/6293 | 381/18723 | 4.26e-06 | 4.68e-05 | 170 |
GO:00487715 | Thyroid | ATC | tissue remodeling | 78/6293 | 175/18723 | 1.60e-03 | 8.04e-03 | 78 |
GO:0002573110 | Thyroid | ATC | myeloid leukocyte differentiation | 86/6293 | 208/18723 | 1.15e-02 | 4.11e-02 | 86 |
GO:00468491 | Thyroid | ATC | bone remodeling | 41/6293 | 90/18723 | 1.21e-02 | 4.30e-02 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIGLEC15 | SNV | Missense_Mutation | c.902C>A | p.Pro301Gln | p.P301Q | Q6ZMC9 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.521) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIGLEC15 | SNV | Missense_Mutation | c.47N>A | p.Pro16Gln | p.P16Q | Q6ZMC9 | protein_coding | tolerated_low_confidence(0.29) | benign(0.003) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD | |
SIGLEC15 | SNV | Missense_Mutation | c.968N>A | p.Ala323Asp | p.A323D | Q6ZMC9 | protein_coding | tolerated_low_confidence(0.06) | benign(0.326) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SIGLEC15 | SNV | Missense_Mutation | novel | c.952N>A | p.Pro318Thr | p.P318T | Q6ZMC9 | protein_coding | deleterious_low_confidence(0.02) | benign(0.015) | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SIGLEC15 | SNV | Missense_Mutation | c.650G>A | p.Gly217Asp | p.G217D | Q6ZMC9 | protein_coding | tolerated(0.62) | benign(0) | TCGA-39-5016-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SIGLEC15 | SNV | Missense_Mutation | novel | c.956N>C | p.Arg319Pro | p.R319P | Q6ZMC9 | protein_coding | deleterious_low_confidence(0.01) | benign(0.001) | TCGA-98-A53I-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | navelbine | SD |
SIGLEC15 | insertion | Frame_Shift_Ins | novel | c.713_714insA | p.Ala239GlyfsTer73 | p.A239Gfs*73 | Q6ZMC9 | protein_coding | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | ||
SIGLEC15 | SNV | Missense_Mutation | novel | c.382C>T | p.Arg128Cys | p.R128C | Q6ZMC9 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIGLEC15 | SNV | Missense_Mutation | c.806N>A | p.Gly269Asp | p.G269D | Q6ZMC9 | protein_coding | tolerated(0.1) | possibly_damaging(0.737) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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