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Gene: SIGLEC10 |
Gene summary for SIGLEC10 |
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Gene information | Species | Human | Gene symbol | SIGLEC10 | Gene ID | 89790 |
Gene name | sialic acid binding Ig like lectin 10 | |
Gene Alias | PRO940 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0002250 | UniProtAcc | B7ZL06 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89790 | SIGLEC10 | HCC1 | Human | Liver | HCC | 3.16e-16 | 1.72e+00 | 0.5336 |
89790 | SIGLEC10 | HCC2 | Human | Liver | HCC | 1.00e-24 | 1.90e+00 | 0.5341 |
89790 | SIGLEC10 | HCC5 | Human | Liver | HCC | 2.49e-20 | 1.31e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190303421 | Liver | HCC | regulation of response to wounding | 94/7958 | 167/18723 | 2.19e-04 | 1.66e-03 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIGLEC10 | SNV | Missense_Mutation | novel | c.266N>T | p.Arg89Leu | p.R89L | Q96LC7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SIGLEC10 | SNV | Missense_Mutation | novel | c.518G>A | p.Cys173Tyr | p.C173Y | Q96LC7 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SIGLEC10 | SNV | Missense_Mutation | rs772709558 | c.1832N>A | p.Arg611Gln | p.R611Q | Q96LC7 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-A6-2685-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SIGLEC10 | SNV | Missense_Mutation | novel | c.550N>A | p.Ala184Thr | p.A184T | Q96LC7 | protein_coding | tolerated(0.09) | possibly_damaging(0.734) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIGLEC10 | SNV | Missense_Mutation | c.1381C>T | p.His461Tyr | p.H461Y | Q96LC7 | protein_coding | tolerated(0.81) | possibly_damaging(0.555) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SIGLEC10 | SNV | Missense_Mutation | rs201868126 | c.1655C>T | p.Ala552Val | p.A552V | Q96LC7 | protein_coding | tolerated(0.96) | benign(0.014) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SIGLEC10 | SNV | Missense_Mutation | c.530C>A | p.Ser177Tyr | p.S177Y | Q96LC7 | protein_coding | deleterious(0.02) | possibly_damaging(0.82) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SIGLEC10 | SNV | Missense_Mutation | c.1756C>T | p.Pro586Ser | p.P586S | Q96LC7 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SIGLEC10 | SNV | Missense_Mutation | c.1381C>T | p.His461Tyr | p.H461Y | Q96LC7 | protein_coding | tolerated(0.81) | possibly_damaging(0.555) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SIGLEC10 | SNV | Missense_Mutation | rs201054656 | c.26C>T | p.Ser9Leu | p.S9L | Q96LC7 | protein_coding | tolerated_low_confidence(0.37) | benign(0) | TCGA-AZ-4614-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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