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Gene: SH3GLB2 |
Gene summary for SH3GLB2 |
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Gene information | Species | Human | Gene symbol | SH3GLB2 | Gene ID | 56904 |
Gene name | SH3 domain containing GRB2 like, endophilin B2 | |
Gene Alias | PP6569 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NR46 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56904 | SH3GLB2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.29e-03 | 9.54e-02 | 0.0155 |
56904 | SH3GLB2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.26e-04 | 2.24e-01 | -0.1808 |
56904 | SH3GLB2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.53e-09 | 3.76e-01 | -0.0811 |
56904 | SH3GLB2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.33e-13 | 3.43e-01 | -0.1954 |
56904 | SH3GLB2 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.42e-05 | 5.86e-01 | -0.2602 |
56904 | SH3GLB2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.40e-05 | 3.33e-01 | -0.1526 |
56904 | SH3GLB2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.35e-02 | 2.73e-01 | -0.1464 |
56904 | SH3GLB2 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.89e-03 | 2.27e-01 | -0.1001 |
56904 | SH3GLB2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.80e-10 | 3.72e-01 | -0.059 |
56904 | SH3GLB2 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.71e-03 | 9.62e-02 | 0.096 |
56904 | SH3GLB2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.46e-02 | 4.53e-01 | 0.0451 |
56904 | SH3GLB2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.97e-02 | 3.22e-01 | 0.0131 |
56904 | SH3GLB2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.12e-08 | 3.85e-01 | -0.0177 |
56904 | SH3GLB2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.30e-02 | 1.20e-01 | 0.0674 |
56904 | SH3GLB2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.69e-02 | 7.16e-01 | 0.3487 |
56904 | SH3GLB2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.70e-02 | 3.34e-01 | 0.3859 |
56904 | SH3GLB2 | A015-C-203 | Human | Colorectum | FAP | 5.13e-03 | 3.13e-01 | -0.1294 |
56904 | SH3GLB2 | LZE7T | Human | Esophagus | ESCC | 1.48e-03 | 1.50e-01 | 0.0667 |
56904 | SH3GLB2 | LZE20T | Human | Esophagus | ESCC | 4.39e-06 | 3.09e-01 | 0.0662 |
56904 | SH3GLB2 | LZE24T | Human | Esophagus | ESCC | 4.38e-11 | 9.66e-02 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SH3GLB2 | SNV | Missense_Mutation | rs112735794 | c.764N>A | p.Arg255His | p.R255H | Q9NR46 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SH3GLB2 | SNV | Missense_Mutation | rs547612052 | c.859N>A | p.Gly287Ser | p.G287S | Q9NR46 | protein_coding | tolerated(0.38) | benign(0.01) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SH3GLB2 | SNV | Missense_Mutation | novel | c.1069G>A | p.Ala357Thr | p.A357T | Q9NR46 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SH3GLB2 | SNV | Missense_Mutation | novel | c.830A>G | p.Asp277Gly | p.D277G | Q9NR46 | protein_coding | deleterious(0) | possibly_damaging(0.547) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SH3GLB2 | SNV | Missense_Mutation | c.614T>G | p.Ile205Ser | p.I205S | Q9NR46 | protein_coding | deleterious(0.04) | possibly_damaging(0.65) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SH3GLB2 | SNV | Missense_Mutation | rs138289691 | c.134N>A | p.Arg45Gln | p.R45Q | Q9NR46 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SH3GLB2 | SNV | Missense_Mutation | novel | c.542N>A | p.Ala181Asp | p.A181D | Q9NR46 | protein_coding | tolerated(0.18) | possibly_damaging(0.691) | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SH3GLB2 | SNV | Missense_Mutation | novel | c.150N>T | p.Lys50Asn | p.K50N | Q9NR46 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SH3GLB2 | SNV | Missense_Mutation | novel | c.301N>A | p.Ala101Thr | p.A101T | Q9NR46 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SH3GLB2 | SNV | Missense_Mutation | novel | c.578N>C | p.Val193Ala | p.V193A | Q9NR46 | protein_coding | tolerated(0.68) | benign(0.001) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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