![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SFTPB |
Gene summary for SFTPB |
![]() |
Gene information | Species | Human | Gene symbol | SFTPB | Gene ID | 6439 |
Gene name | surfactant protein B | |
Gene Alias | PSP-B | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | D6W5L6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6439 | SFTPB | HCC1 | Human | Liver | HCC | 3.12e-03 | 5.51e-01 | 0.5336 |
6439 | SFTPB | HCC2 | Human | Liver | HCC | 7.17e-15 | 1.12e+00 | 0.5341 |
6439 | SFTPB | HCC5 | Human | Liver | HCC | 9.51e-14 | 6.82e-01 | 0.4932 |
6439 | SFTPB | TD9 | Human | Lung | IAC | 3.80e-18 | -3.26e-01 | 0.088 |
6439 | SFTPB | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 6.03e-04 | -1.49e-01 | -0.1271 |
6439 | SFTPB | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 2.83e-03 | -1.41e-01 | -0.1406 |
6439 | SFTPB | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.08e-36 | -2.60e+00 | 0.3371 |
6439 | SFTPB | RNA-P17T-P17T-4 | Human | Lung | IAC | 6.26e-37 | -2.35e+00 | 0.343 |
6439 | SFTPB | RNA-P17T-P17T-6 | Human | Lung | IAC | 3.94e-46 | -2.25e+00 | 0.3385 |
6439 | SFTPB | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.43e-28 | -2.26e+00 | 0.3329 |
6439 | SFTPB | RNA-P18T-P18T-2 | Human | Lung | IAC | 2.11e-13 | -4.58e-01 | 0.1129 |
6439 | SFTPB | RNA-P18T-P18T-4 | Human | Lung | IAC | 1.24e-08 | -3.91e-01 | 0.1024 |
6439 | SFTPB | RNA-P18T-P18T-6 | Human | Lung | IAC | 1.57e-11 | -3.21e-01 | 0.0856 |
6439 | SFTPB | RNA-P18T-P18T-8 | Human | Lung | IAC | 1.06e-05 | -2.47e-01 | 0.1151 |
6439 | SFTPB | RNA-P23T2-P23T2-1 | Human | Lung | MIAC | 3.10e-10 | -2.44e-01 | -0.037 |
6439 | SFTPB | RNA-P23T2-P23T2-2 | Human | Lung | MIAC | 9.48e-09 | -1.94e-01 | -0.028 |
6439 | SFTPB | RNA-P23T2-P23T2-4 | Human | Lung | MIAC | 1.32e-09 | -2.43e-01 | -0.0272 |
6439 | SFTPB | RNA-P24T2-P24T2-2 | Human | Lung | IAC | 2.54e-23 | -5.89e-01 | 0.0057 |
6439 | SFTPB | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 5.25e-19 | -2.15e-01 | -0.2116 |
6439 | SFTPB | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 7.16e-13 | -2.63e-01 | -0.1941 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066431 | Liver | HCC | membrane lipid metabolic process | 115/7958 | 203/18723 | 3.17e-05 | 3.22e-04 | 115 |
GO:0006665 | Liver | HCC | sphingolipid metabolic process | 85/7958 | 155/18723 | 1.27e-03 | 6.92e-03 | 85 |
GO:0007585 | Lung | IAC | respiratory gaseous exchange by respiratory system | 18/2061 | 68/18723 | 2.99e-04 | 4.82e-03 | 18 |
GO:00075851 | Lung | AIS | respiratory gaseous exchange by respiratory system | 15/1849 | 68/18723 | 2.24e-03 | 2.38e-02 | 15 |
GO:00075852 | Lung | AAH | respiratory gaseous exchange by respiratory system | 8/613 | 68/18723 | 1.65e-03 | 4.01e-02 | 8 |
GO:00075853 | Lung | MIAC | respiratory gaseous exchange by respiratory system | 11/967 | 68/18723 | 6.76e-04 | 1.59e-02 | 11 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SFTPB | SNV | Missense_Mutation | c.43N>A | p.Glu15Lys | p.E15K | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-F5-6464-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SFTPB | SNV | Missense_Mutation | c.979C>A | p.Gln327Lys | p.Q327K | protein_coding | tolerated(0.14) | benign(0.03) | TCGA-A5-A0GR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SFTPB | SNV | Missense_Mutation | rs370715446 | c.529N>T | p.Arg177Trp | p.R177W | protein_coding | deleterious(0.02) | benign(0) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
SFTPB | SNV | Missense_Mutation | rs370715446 | c.529C>T | p.Arg177Trp | p.R177W | protein_coding | deleterious(0.02) | benign(0) | TCGA-AP-A5FX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
SFTPB | SNV | Missense_Mutation | novel | c.983C>T | p.Ala328Val | p.A328V | protein_coding | deleterious(0.05) | benign(0.255) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SFTPB | SNV | Missense_Mutation | rs753519344 | c.262N>A | p.Val88Ile | p.V88I | protein_coding | tolerated(0.41) | benign(0.072) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SFTPB | SNV | Missense_Mutation | novel | c.278N>C | p.Lys93Thr | p.K93T | protein_coding | deleterious(0.01) | possibly_damaging(0.624) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SFTPB | SNV | Missense_Mutation | rs45557339 | c.388N>A | p.Asp130Asn | p.D130N | protein_coding | tolerated(0.46) | benign(0.051) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SFTPB | SNV | Missense_Mutation | c.1012N>A | p.Val338Ile | p.V338I | protein_coding | tolerated(0.29) | benign(0.021) | TCGA-D1-A101-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SFTPB | SNV | Missense_Mutation | novel | c.633N>T | p.Gln211His | p.Q211H | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-DI-A2QU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6439 | SFTPB | DRUGGABLE GENOME | STZ | STREPTOZOCIN | 1386745 |
Page: 1 |