![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SEL1L |
Gene summary for SEL1L |
![]() |
Gene information | Species | Human | Gene symbol | SEL1L | Gene ID | 6400 |
Gene name | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase | |
Gene Alias | Hrd3 | |
Cytomap | 14q31.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9UBV2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6400 | SEL1L | LZE2T | Human | Esophagus | ESCC | 5.31e-07 | 8.52e-01 | 0.082 |
6400 | SEL1L | LZE4T | Human | Esophagus | ESCC | 3.04e-17 | 4.69e-01 | 0.0811 |
6400 | SEL1L | LZE5T | Human | Esophagus | ESCC | 2.22e-05 | 5.75e-01 | 0.0514 |
6400 | SEL1L | LZE7T | Human | Esophagus | ESCC | 2.73e-03 | 2.07e-01 | 0.0667 |
6400 | SEL1L | LZE8T | Human | Esophagus | ESCC | 9.93e-05 | 1.67e-01 | 0.067 |
6400 | SEL1L | LZE22T | Human | Esophagus | ESCC | 3.63e-14 | 8.70e-01 | 0.068 |
6400 | SEL1L | LZE24T | Human | Esophagus | ESCC | 4.91e-17 | 3.67e-01 | 0.0596 |
6400 | SEL1L | LZE21T | Human | Esophagus | ESCC | 2.31e-03 | 3.10e-01 | 0.0655 |
6400 | SEL1L | LZE6T | Human | Esophagus | ESCC | 7.18e-06 | 2.04e-01 | 0.0845 |
6400 | SEL1L | P1T-E | Human | Esophagus | ESCC | 2.37e-11 | 4.78e-01 | 0.0875 |
6400 | SEL1L | P2T-E | Human | Esophagus | ESCC | 2.03e-21 | 3.86e-01 | 0.1177 |
6400 | SEL1L | P4T-E | Human | Esophagus | ESCC | 4.25e-20 | 4.62e-01 | 0.1323 |
6400 | SEL1L | P5T-E | Human | Esophagus | ESCC | 8.04e-21 | 3.15e-01 | 0.1327 |
6400 | SEL1L | P8T-E | Human | Esophagus | ESCC | 1.40e-30 | 5.56e-01 | 0.0889 |
6400 | SEL1L | P9T-E | Human | Esophagus | ESCC | 1.11e-08 | 1.69e-01 | 0.1131 |
6400 | SEL1L | P10T-E | Human | Esophagus | ESCC | 6.69e-38 | 7.68e-01 | 0.116 |
6400 | SEL1L | P11T-E | Human | Esophagus | ESCC | 1.10e-16 | 9.05e-01 | 0.1426 |
6400 | SEL1L | P12T-E | Human | Esophagus | ESCC | 8.10e-29 | 7.52e-01 | 0.1122 |
6400 | SEL1L | P15T-E | Human | Esophagus | ESCC | 5.27e-46 | 1.12e+00 | 0.1149 |
6400 | SEL1L | P16T-E | Human | Esophagus | ESCC | 2.41e-24 | 4.95e-01 | 0.1153 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0050821111 | Esophagus | ESCC | protein stabilization | 140/8552 | 191/18723 | 6.50e-15 | 3.61e-13 | 140 |
GO:003650315 | Esophagus | ESCC | ERAD pathway | 82/8552 | 107/18723 | 5.80e-11 | 1.84e-09 | 82 |
GO:003043314 | Esophagus | ESCC | ubiquitin-dependent ERAD pathway | 66/8552 | 85/18723 | 1.64e-09 | 3.78e-08 | 66 |
GO:003252714 | Esophagus | ESCC | protein exit from endoplasmic reticulum | 37/8552 | 48/18723 | 8.99e-06 | 8.65e-05 | 37 |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:003097014 | Esophagus | ESCC | retrograde protein transport, ER to cytosol | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:190351314 | Esophagus | ESCC | endoplasmic reticulum to cytosol transport | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:007169210 | Esophagus | ESCC | protein localization to extracellular region | 193/8552 | 368/18723 | 5.01e-03 | 1.92e-02 | 193 |
GO:00431617 | Liver | NAFLD | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/1882 | 412/18723 | 3.00e-13 | 1.75e-10 | 91 |
GO:00104987 | Liver | NAFLD | proteasomal protein catabolic process | 101/1882 | 490/18723 | 1.35e-12 | 6.09e-10 | 101 |
GO:00316477 | Liver | NAFLD | regulation of protein stability | 61/1882 | 298/18723 | 5.00e-08 | 4.71e-06 | 61 |
GO:00066413 | Liver | NAFLD | triglyceride metabolic process | 29/1882 | 100/18723 | 9.51e-08 | 7.62e-06 | 29 |
GO:00066392 | Liver | NAFLD | acylglycerol metabolic process | 32/1882 | 128/18723 | 8.82e-07 | 4.60e-05 | 32 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa04141210 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
hsa0414138 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
hsa0414128 | Prostate | BPH | Protein processing in endoplasmic reticulum | 97/1718 | 174/8465 | 2.37e-25 | 1.30e-23 | 8.07e-24 | 97 |
hsa04141112 | Prostate | BPH | Protein processing in endoplasmic reticulum | 97/1718 | 174/8465 | 2.37e-25 | 1.30e-23 | 8.07e-24 | 97 |
hsa0414129 | Prostate | Tumor | Protein processing in endoplasmic reticulum | 99/1791 | 174/8465 | 2.58e-25 | 1.71e-23 | 1.06e-23 | 99 |
hsa0414137 | Prostate | Tumor | Protein processing in endoplasmic reticulum | 99/1791 | 174/8465 | 2.58e-25 | 1.71e-23 | 1.06e-23 | 99 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEL1L | SNV | Missense_Mutation | c.1232A>G | p.His411Arg | p.H411R | Q9UBV2 | protein_coding | tolerated(0.34) | possibly_damaging(0.647) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SEL1L | SNV | Missense_Mutation | rs778475218 | c.779N>T | p.Ala260Val | p.A260V | Q9UBV2 | protein_coding | tolerated(0.06) | possibly_damaging(0.569) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SEL1L | SNV | Missense_Mutation | novel | c.1193T>C | p.Phe398Ser | p.F398S | Q9UBV2 | protein_coding | tolerated(0.06) | benign(0.076) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SEL1L | SNV | Missense_Mutation | c.1996N>A | p.Ala666Thr | p.A666T | Q9UBV2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SEL1L | SNV | Missense_Mutation | novel | c.1914C>A | p.Phe638Leu | p.F638L | Q9UBV2 | protein_coding | deleterious(0.04) | benign(0.403) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SEL1L | SNV | Missense_Mutation | rs775891234 | c.1262C>T | p.Ser421Leu | p.S421L | Q9UBV2 | protein_coding | tolerated(1) | benign(0.058) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SEL1L | SNV | Missense_Mutation | novel | c.195N>C | p.Glu65Asp | p.E65D | Q9UBV2 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SEL1L | SNV | Missense_Mutation | rs769333290 | c.2332C>T | p.Arg778Trp | p.R778W | Q9UBV2 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.798) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEL1L | SNV | Missense_Mutation | novel | c.558G>A | p.Met186Ile | p.M186I | Q9UBV2 | protein_coding | tolerated(0.26) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEL1L | SNV | Missense_Mutation | rs568479591 | c.1600N>A | p.Gly534Ser | p.G534S | Q9UBV2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |