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Gene: SECTM1 |
Gene summary for SECTM1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SECTM1 | Gene ID | 6398 |
Gene name | secreted and transmembrane 1 | |
Gene Alias | K12 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8WVN6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6398 | SECTM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.61e-06 | 4.99e-01 | -0.1808 |
6398 | SECTM1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.79e-03 | 1.16e+00 | -0.2602 |
6398 | SECTM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.33e-06 | 4.58e-01 | -0.1207 |
6398 | SECTM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.90e-04 | 3.75e-01 | -0.059 |
6398 | SECTM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.17e-05 | 9.40e-01 | -0.2061 |
6398 | SECTM1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.10e-02 | 2.34e-01 | 0.294 |
6398 | SECTM1 | LZE24D1 | Human | Esophagus | HGIN | 4.84e-03 | 7.14e-01 | 0.054 |
6398 | SECTM1 | LZE24T | Human | Esophagus | ESCC | 2.85e-21 | 8.46e-01 | 0.0596 |
6398 | SECTM1 | P2T-E | Human | Esophagus | ESCC | 2.06e-09 | 2.97e-02 | 0.1177 |
6398 | SECTM1 | P9T-E | Human | Esophagus | ESCC | 3.47e-09 | 2.62e-01 | 0.1131 |
6398 | SECTM1 | P21T-E | Human | Esophagus | ESCC | 4.58e-17 | 2.72e-01 | 0.1617 |
6398 | SECTM1 | P26T-E | Human | Esophagus | ESCC | 8.11e-08 | 5.21e-02 | 0.1276 |
6398 | SECTM1 | P27T-E | Human | Esophagus | ESCC | 3.56e-03 | 4.09e-02 | 0.1055 |
6398 | SECTM1 | P39T-E | Human | Esophagus | ESCC | 2.60e-04 | 1.37e-01 | 0.0894 |
6398 | SECTM1 | P40T-E | Human | Esophagus | ESCC | 3.61e-06 | 2.00e-01 | 0.109 |
6398 | SECTM1 | P48T-E | Human | Esophagus | ESCC | 7.19e-04 | 2.71e-02 | 0.0959 |
6398 | SECTM1 | P52T-E | Human | Esophagus | ESCC | 5.87e-03 | 1.35e-01 | 0.1555 |
6398 | SECTM1 | P54T-E | Human | Esophagus | ESCC | 2.54e-02 | 1.25e-01 | 0.0975 |
6398 | SECTM1 | P57T-E | Human | Esophagus | ESCC | 1.01e-08 | 8.21e-02 | 0.0926 |
6398 | SECTM1 | P61T-E | Human | Esophagus | ESCC | 1.61e-05 | 1.21e-01 | 0.099 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043123 | Colorectum | AD | positive regulation of I-kappaB kinase/NF-kappaB signaling | 60/3918 | 186/18723 | 1.91e-04 | 2.56e-03 | 60 |
GO:0043122 | Colorectum | AD | regulation of I-kappaB kinase/NF-kappaB signaling | 76/3918 | 249/18723 | 2.17e-04 | 2.85e-03 | 76 |
GO:0007249 | Colorectum | AD | I-kappaB kinase/NF-kappaB signaling | 82/3918 | 281/18723 | 6.09e-04 | 6.40e-03 | 82 |
GO:00431221 | Colorectum | MSS | regulation of I-kappaB kinase/NF-kappaB signaling | 71/3467 | 249/18723 | 7.12e-05 | 1.21e-03 | 71 |
GO:00072491 | Colorectum | MSS | I-kappaB kinase/NF-kappaB signaling | 77/3467 | 281/18723 | 1.51e-04 | 2.19e-03 | 77 |
GO:00431231 | Colorectum | MSS | positive regulation of I-kappaB kinase/NF-kappaB signaling | 55/3467 | 186/18723 | 1.60e-04 | 2.29e-03 | 55 |
GO:004312318 | Esophagus | ESCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 132/8552 | 186/18723 | 2.07e-12 | 8.58e-11 | 132 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SECTM1 | SNV | Missense_Mutation | rs745434411 | c.619G>A | p.Ala207Thr | p.A207T | Q8WVN6 | protein_coding | deleterious_low_confidence(0.01) | benign(0.001) | TCGA-33-AASD-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SECTM1 | SNV | Missense_Mutation | novel | c.331C>A | p.His111Asn | p.H111N | Q8WVN6 | protein_coding | deleterious(0.01) | possibly_damaging(0.556) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SECTM1 | deletion | Frame_Shift_Del | novel | c.17_24delNNNNNNNN | p.Leu6ProfsTer23 | p.L6Pfs*23 | Q8WVN6 | protein_coding | TCGA-66-2782-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unspecific | PD | |||
SECTM1 | insertion | Frame_Shift_Ins | novel | c.16dupC | p.Leu6ProfsTer26 | p.L6Pfs*26 | Q8WVN6 | protein_coding | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | ||
SECTM1 | SNV | Missense_Mutation | novel | c.68N>A | p.Ala23Asp | p.A23D | Q8WVN6 | protein_coding | tolerated(0.08) | benign(0.047) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SECTM1 | SNV | Missense_Mutation | c.634N>A | p.Pro212Thr | p.P212T | Q8WVN6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.468) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SECTM1 | SNV | Missense_Mutation | novel | c.704N>C | p.Leu235Pro | p.L235P | Q8WVN6 | protein_coding | deleterious_low_confidence(0.01) | benign(0.354) | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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