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Gene: SEC24B |
Gene summary for SEC24B |
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Gene information | Species | Human | Gene symbol | SEC24B | Gene ID | 10427 |
Gene name | SEC24 homolog B, COPII coat complex component | |
Gene Alias | SEC24 | |
Cytomap | 4q25 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O95487 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10427 | SEC24B | CCI_1 | Human | Cervix | CC | 1.78e-06 | 8.01e-01 | 0.528 |
10427 | SEC24B | CCI_2 | Human | Cervix | CC | 6.13e-06 | 6.83e-01 | 0.5249 |
10427 | SEC24B | CCI_3 | Human | Cervix | CC | 1.62e-03 | 4.97e-01 | 0.516 |
10427 | SEC24B | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.93e-19 | -6.20e-01 | 0.0155 |
10427 | SEC24B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.30e-07 | -5.24e-01 | -0.1207 |
10427 | SEC24B | HTA11_83_2000001011 | Human | Colorectum | SER | 8.81e-03 | -4.39e-01 | -0.1526 |
10427 | SEC24B | HTA11_696_2000001011 | Human | Colorectum | AD | 3.34e-04 | -3.69e-01 | -0.1464 |
10427 | SEC24B | HTA11_866_2000001011 | Human | Colorectum | AD | 4.62e-06 | -3.47e-01 | -0.1001 |
10427 | SEC24B | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.11e-03 | -5.86e-01 | -0.2061 |
10427 | SEC24B | HTA11_866_3004761011 | Human | Colorectum | AD | 5.74e-08 | -4.83e-01 | 0.096 |
10427 | SEC24B | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.25e-14 | -4.91e-01 | 0.0674 |
10427 | SEC24B | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.31e-04 | -5.34e-01 | 0.0588 |
10427 | SEC24B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.72e-05 | -3.31e-01 | 0.294 |
10427 | SEC24B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.10e-04 | -3.22e-01 | 0.3859 |
10427 | SEC24B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.43e-05 | -5.96e-01 | 0.2585 |
10427 | SEC24B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.02e-17 | -5.04e-01 | 0.3005 |
10427 | SEC24B | F007 | Human | Colorectum | FAP | 1.66e-02 | -3.82e-01 | 0.1176 |
10427 | SEC24B | A002-C-010 | Human | Colorectum | FAP | 8.00e-03 | -2.71e-01 | 0.242 |
10427 | SEC24B | A001-C-207 | Human | Colorectum | FAP | 8.39e-06 | -4.12e-01 | 0.1278 |
10427 | SEC24B | A015-C-203 | Human | Colorectum | FAP | 7.62e-34 | -5.84e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00099137 | Cervix | CC | epidermal cell differentiation | 53/2311 | 202/18723 | 5.48e-08 | 3.25e-06 | 53 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:000690010 | Cervix | CC | vesicle budding from membrane | 20/2311 | 61/18723 | 2.50e-05 | 4.28e-04 | 20 |
GO:00481938 | Cervix | CC | Golgi vesicle transport | 58/2311 | 296/18723 | 2.24e-04 | 2.54e-03 | 58 |
GO:000206410 | Cervix | CC | epithelial cell development | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:00488579 | Cervix | CC | neural nucleus development | 18/2311 | 64/18723 | 5.42e-04 | 5.23e-03 | 18 |
GO:00604253 | Cervix | CC | lung morphogenesis | 15/2311 | 50/18723 | 7.36e-04 | 6.60e-03 | 15 |
GO:00303245 | Cervix | CC | lung development | 36/2311 | 177/18723 | 1.64e-03 | 1.26e-02 | 36 |
GO:00351487 | Cervix | CC | tube formation | 31/2311 | 148/18723 | 2.07e-03 | 1.51e-02 | 31 |
GO:00017384 | Cervix | CC | morphogenesis of a polarized epithelium | 22/2311 | 94/18723 | 2.09e-03 | 1.52e-02 | 22 |
GO:00303235 | Cervix | CC | respiratory tube development | 36/2311 | 181/18723 | 2.46e-03 | 1.71e-02 | 36 |
GO:00160506 | Cervix | CC | vesicle organization | 54/2311 | 300/18723 | 2.71e-03 | 1.85e-02 | 54 |
GO:00018417 | Cervix | CC | neural tube formation | 23/2311 | 102/18723 | 2.80e-03 | 1.87e-02 | 23 |
GO:00605413 | Cervix | CC | respiratory system development | 39/2311 | 203/18723 | 3.18e-03 | 2.07e-02 | 39 |
GO:00605626 | Cervix | CC | epithelial tube morphogenesis | 57/2311 | 325/18723 | 3.79e-03 | 2.41e-02 | 57 |
GO:00140206 | Cervix | CC | primary neural tube formation | 21/2311 | 94/18723 | 4.68e-03 | 2.82e-02 | 21 |
GO:00219156 | Cervix | CC | neural tube development | 30/2311 | 152/18723 | 6.00e-03 | 3.43e-02 | 30 |
GO:00901752 | Cervix | CC | regulation of establishment of planar polarity | 14/2311 | 56/18723 | 6.93e-03 | 3.74e-02 | 14 |
GO:00018435 | Cervix | CC | neural tube closure | 19/2311 | 88/18723 | 1.01e-02 | 4.91e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513020 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa05130110 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa051302 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa051303 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa051304 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa051305 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
hsa051308 | Colorectum | FAP | Pathogenic Escherichia coli infection | 62/1404 | 197/8465 | 1.37e-07 | 3.08e-06 | 1.87e-06 | 62 |
hsa041418 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa051309 | Colorectum | FAP | Pathogenic Escherichia coli infection | 62/1404 | 197/8465 | 1.37e-07 | 3.08e-06 | 1.87e-06 | 62 |
hsa041419 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEC24B | SNV | Missense_Mutation | rs771974068 | c.899C>T | p.Ser300Leu | p.S300L | O95487 | protein_coding | tolerated_low_confidence(0.1) | benign(0.091) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SEC24B | SNV | Missense_Mutation | rs758546508 | c.1627N>T | p.Leu543Phe | p.L543F | O95487 | protein_coding | deleterious(0.03) | possibly_damaging(0.786) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SEC24B | SNV | Missense_Mutation | rs200484889 | c.1222N>A | p.Asp408Asn | p.D408N | O95487 | protein_coding | tolerated_low_confidence(0.11) | benign(0.357) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
SEC24B | SNV | Missense_Mutation | c.823C>T | p.Pro275Ser | p.P275S | O95487 | protein_coding | tolerated_low_confidence(0.11) | possibly_damaging(0.796) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SEC24B | SNV | Missense_Mutation | c.1862N>C | p.Leu621Pro | p.L621P | O95487 | protein_coding | deleterious(0.02) | probably_damaging(0.913) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SEC24B | SNV | Missense_Mutation | rs770989941 | c.2510N>A | p.Arg837His | p.R837H | O95487 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3685-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SEC24B | SNV | Missense_Mutation | c.3071N>A | p.Arg1024Lys | p.R1024K | O95487 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SEC24B | SNV | Missense_Mutation | c.1803G>T | p.Gln601His | p.Q601H | O95487 | protein_coding | tolerated(0.06) | possibly_damaging(0.757) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SEC24B | SNV | Missense_Mutation | rs747589922 | c.1420T>C | p.Ser474Pro | p.S474P | O95487 | protein_coding | tolerated(1) | benign(0.01) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEC24B | SNV | Missense_Mutation | rs750393639 | c.1990N>A | p.Asp664Asn | p.D664N | O95487 | protein_coding | deleterious(0) | benign(0.359) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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