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Gene: SEC24A |
Gene summary for SEC24A |
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Gene information | Species | Human | Gene symbol | SEC24A | Gene ID | 10802 |
Gene name | SEC24 homolog A, COPII coat complex component | |
Gene Alias | SEC24A | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B4E205 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10802 | SEC24A | LZE4T | Human | Esophagus | ESCC | 1.19e-03 | 1.55e-02 | 0.0811 |
10802 | SEC24A | LZE7T | Human | Esophagus | ESCC | 5.18e-06 | 1.26e-01 | 0.0667 |
10802 | SEC24A | LZE8T | Human | Esophagus | ESCC | 4.37e-02 | 7.31e-02 | 0.067 |
10802 | SEC24A | LZE22T | Human | Esophagus | ESCC | 1.23e-02 | 1.17e-01 | 0.068 |
10802 | SEC24A | LZE24T | Human | Esophagus | ESCC | 1.51e-04 | 1.00e-01 | 0.0596 |
10802 | SEC24A | P2T-E | Human | Esophagus | ESCC | 9.50e-17 | 1.00e-01 | 0.1177 |
10802 | SEC24A | P4T-E | Human | Esophagus | ESCC | 6.03e-08 | 2.11e-01 | 0.1323 |
10802 | SEC24A | P5T-E | Human | Esophagus | ESCC | 1.96e-05 | 5.71e-02 | 0.1327 |
10802 | SEC24A | P8T-E | Human | Esophagus | ESCC | 8.43e-08 | 1.39e-01 | 0.0889 |
10802 | SEC24A | P9T-E | Human | Esophagus | ESCC | 4.72e-08 | 6.38e-02 | 0.1131 |
10802 | SEC24A | P10T-E | Human | Esophagus | ESCC | 1.87e-08 | 4.86e-02 | 0.116 |
10802 | SEC24A | P11T-E | Human | Esophagus | ESCC | 1.05e-08 | 3.23e-01 | 0.1426 |
10802 | SEC24A | P12T-E | Human | Esophagus | ESCC | 3.72e-10 | 1.14e-01 | 0.1122 |
10802 | SEC24A | P15T-E | Human | Esophagus | ESCC | 1.18e-15 | 1.14e-01 | 0.1149 |
10802 | SEC24A | P16T-E | Human | Esophagus | ESCC | 3.59e-13 | 2.83e-02 | 0.1153 |
10802 | SEC24A | P19T-E | Human | Esophagus | ESCC | 7.76e-05 | 3.00e-01 | 0.1662 |
10802 | SEC24A | P20T-E | Human | Esophagus | ESCC | 6.13e-09 | 4.74e-02 | 0.1124 |
10802 | SEC24A | P21T-E | Human | Esophagus | ESCC | 4.14e-19 | 1.11e-01 | 0.1617 |
10802 | SEC24A | P22T-E | Human | Esophagus | ESCC | 1.02e-16 | 1.05e-01 | 0.1236 |
10802 | SEC24A | P23T-E | Human | Esophagus | ESCC | 2.03e-10 | 2.57e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:0006900111 | Esophagus | ESCC | vesicle budding from membrane | 54/8552 | 61/18723 | 2.66e-12 | 1.07e-10 | 54 |
GO:009011414 | Esophagus | ESCC | COPII-coated vesicle budding | 27/8552 | 29/18723 | 8.09e-08 | 1.39e-06 | 27 |
GO:00901104 | Esophagus | ESCC | COPII-coated vesicle cargo loading | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00354595 | Esophagus | ESCC | vesicle cargo loading | 19/8552 | 27/18723 | 8.35e-03 | 2.95e-02 | 19 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
GO:000688811 | Liver | Cirrhotic | endoplasmic reticulum to Golgi vesicle-mediated transport | 77/4634 | 130/18723 | 5.78e-17 | 7.56e-15 | 77 |
GO:001605011 | Liver | Cirrhotic | vesicle organization | 133/4634 | 300/18723 | 7.35e-14 | 6.41e-12 | 133 |
GO:000690012 | Liver | Cirrhotic | vesicle budding from membrane | 41/4634 | 61/18723 | 3.12e-12 | 2.25e-10 | 41 |
GO:009011411 | Liver | Cirrhotic | COPII-coated vesicle budding | 21/4634 | 29/18723 | 8.97e-08 | 2.63e-06 | 21 |
GO:003545911 | Liver | Cirrhotic | vesicle cargo loading | 15/4634 | 27/18723 | 5.96e-04 | 4.63e-03 | 15 |
GO:00901101 | Liver | Cirrhotic | COPII-coated vesicle cargo loading | 10/4634 | 15/18723 | 7.26e-04 | 5.36e-03 | 10 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:000688821 | Liver | HCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 100/7958 | 130/18723 | 1.15e-15 | 8.67e-14 | 100 |
GO:001605021 | Liver | HCC | vesicle organization | 194/7958 | 300/18723 | 5.58e-15 | 3.97e-13 | 194 |
GO:000690021 | Liver | HCC | vesicle budding from membrane | 53/7958 | 61/18723 | 7.38e-13 | 3.80e-11 | 53 |
GO:00901142 | Liver | HCC | COPII-coated vesicle budding | 27/7958 | 29/18723 | 1.28e-08 | 3.14e-07 | 27 |
GO:00901102 | Liver | HCC | COPII-coated vesicle cargo loading | 14/7958 | 15/18723 | 5.65e-05 | 5.26e-04 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa05130310 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0513022 | Liver | Cirrhotic | Pathogenic Escherichia coli infection | 88/2530 | 197/8465 | 6.48e-06 | 6.24e-05 | 3.84e-05 | 88 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0513032 | Liver | Cirrhotic | Pathogenic Escherichia coli infection | 88/2530 | 197/8465 | 6.48e-06 | 6.24e-05 | 3.84e-05 | 88 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0513042 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0513052 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEC24A | deletion | Frame_Shift_Del | novel | c.1709delN | p.Ser571GlnfsTer15 | p.S571Qfs*15 | O95486 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SEC24A | SNV | Missense_Mutation | rs771692677 | c.3130N>A | p.Glu1044Lys | p.E1044K | O95486 | protein_coding | tolerated(0.1) | benign(0.017) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
SEC24A | SNV | Missense_Mutation | rs779769399 | c.2153N>G | p.Ser718Cys | p.S718C | O95486 | protein_coding | deleterious(0.01) | possibly_damaging(0.835) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SEC24A | SNV | Missense_Mutation | novel | c.368N>T | p.Ser123Phe | p.S123F | O95486 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.564) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SEC24A | SNV | Missense_Mutation | novel | c.1246G>T | p.Asp416Tyr | p.D416Y | O95486 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
SEC24A | SNV | Missense_Mutation | rs766877569 | c.2587N>A | p.Ala863Thr | p.A863T | O95486 | protein_coding | deleterious(0.02) | possibly_damaging(0.453) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEC24A | SNV | Missense_Mutation | novel | c.253N>C | p.Thr85Pro | p.T85P | O95486 | protein_coding | tolerated_low_confidence(0.07) | benign(0.283) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SEC24A | SNV | Missense_Mutation | c.790N>A | p.Asp264Asn | p.D264N | O95486 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SEC24A | SNV | Missense_Mutation | c.2455N>T | p.Arg819Cys | p.R819C | O95486 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SEC24A | SNV | Missense_Mutation | novel | c.3214N>T | p.Asp1072Tyr | p.D1072Y | O95486 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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