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Gene: SDHD |
Gene summary for SDHD |
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Gene information | Species | Human | Gene symbol | SDHD | Gene ID | 6392 |
Gene name | succinate dehydrogenase complex subunit D | |
Gene Alias | CBT1 | |
Cytomap | 11q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | A0A0S2Z4H7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6392 | SDHD | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.90e-11 | 2.41e-01 | 0.0155 |
6392 | SDHD | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.14e-15 | 4.33e-01 | -0.1808 |
6392 | SDHD | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 2.80e-01 | 0.0216 |
6392 | SDHD | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.04e-15 | 5.17e-01 | -0.0811 |
6392 | SDHD | HTA11_78_2000001011 | Human | Colorectum | AD | 6.88e-27 | 6.94e-01 | -0.1088 |
6392 | SDHD | HTA11_347_2000001011 | Human | Colorectum | AD | 1.41e-41 | 7.73e-01 | -0.1954 |
6392 | SDHD | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-12 | 8.01e-01 | -0.2602 |
6392 | SDHD | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.26e-09 | 3.70e-01 | -0.1207 |
6392 | SDHD | HTA11_83_2000001011 | Human | Colorectum | SER | 1.12e-08 | 3.22e-01 | -0.1526 |
6392 | SDHD | HTA11_696_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.37e-01 | -0.1464 |
6392 | SDHD | HTA11_866_2000001011 | Human | Colorectum | AD | 7.82e-13 | 2.67e-01 | -0.1001 |
6392 | SDHD | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.44e-15 | 3.55e-01 | -0.059 |
6392 | SDHD | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.86e-21 | 7.82e-01 | -0.1706 |
6392 | SDHD | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.13e-20 | 7.47e-01 | -0.2061 |
6392 | SDHD | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.90e-01 | -0.1462 |
6392 | SDHD | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-05 | 2.45e-01 | -0.0842 |
6392 | SDHD | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.05e-17 | 6.40e-01 | -0.0179 |
6392 | SDHD | HTA11_866_3004761011 | Human | Colorectum | AD | 5.18e-29 | 5.68e-01 | 0.096 |
6392 | SDHD | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.84e-10 | 4.41e-01 | 0.0446 |
6392 | SDHD | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.15e-09 | 4.03e-01 | 0.0528 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0009060 | Colorectum | AD | aerobic respiration | 108/3918 | 189/18723 | 9.14e-28 | 1.43e-24 | 108 |
GO:0045333 | Colorectum | AD | cellular respiration | 119/3918 | 230/18723 | 3.21e-25 | 4.02e-22 | 119 |
GO:0006119 | Colorectum | AD | oxidative phosphorylation | 83/3918 | 141/18723 | 7.95e-23 | 8.30e-20 | 83 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0022900 | Colorectum | AD | electron transport chain | 89/3918 | 175/18723 | 1.42e-18 | 8.91e-16 | 89 |
GO:0019646 | Colorectum | AD | aerobic electron transport chain | 53/3918 | 87/18723 | 5.58e-16 | 2.16e-13 | 53 |
GO:0042773 | Colorectum | AD | ATP synthesis coupled electron transport | 56/3918 | 95/18723 | 6.76e-16 | 2.22e-13 | 56 |
GO:0042775 | Colorectum | AD | mitochondrial ATP synthesis coupled electron transport | 56/3918 | 95/18723 | 6.76e-16 | 2.22e-13 | 56 |
GO:0022904 | Colorectum | AD | respiratory electron transport chain | 63/3918 | 114/18723 | 8.23e-16 | 2.45e-13 | 63 |
GO:0006099 | Colorectum | AD | tricarboxylic acid cycle | 19/3918 | 30/18723 | 5.82e-07 | 2.09e-05 | 19 |
GO:00090601 | Colorectum | SER | aerobic respiration | 96/2897 | 189/18723 | 5.53e-30 | 1.70e-26 | 96 |
GO:00460341 | Colorectum | SER | ATP metabolic process | 117/2897 | 277/18723 | 5.54e-27 | 1.13e-23 | 117 |
GO:00453331 | Colorectum | SER | cellular respiration | 103/2897 | 230/18723 | 2.35e-26 | 3.61e-23 | 103 |
GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
GO:00061191 | Colorectum | SER | oxidative phosphorylation | 75/2897 | 141/18723 | 2.35e-25 | 2.40e-22 | 75 |
GO:00159801 | Colorectum | SER | energy derivation by oxidation of organic compounds | 119/2897 | 318/18723 | 5.28e-22 | 4.62e-19 | 119 |
GO:00229001 | Colorectum | SER | electron transport chain | 77/2897 | 175/18723 | 1.77e-19 | 1.36e-16 | 77 |
GO:00427731 | Colorectum | SER | ATP synthesis coupled electron transport | 51/2897 | 95/18723 | 6.48e-18 | 3.98e-15 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05208 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa05020 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00020 | Colorectum | AD | Citrate cycle (TCA cycle) | 20/2092 | 30/8465 | 1.43e-06 | 1.77e-05 | 1.13e-05 | 20 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa052081 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SDHD | SNV | Missense_Mutation | novel | c.86C>A | p.Ala29Asp | p.A29D | O14521 | protein_coding | tolerated(0.12) | benign(0.28) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SDHD | SNV | Missense_Mutation | c.134N>A | p.Gly45Glu | p.G45E | O14521 | protein_coding | tolerated(0.29) | benign(0.171) | TCGA-55-6712-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
SDHD | SNV | Missense_Mutation | c.287C>T | p.Ala96Val | p.A96V | O14521 | protein_coding | deleterious(0.02) | possibly_damaging(0.905) | TCGA-55-A48Y-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
SDHD | SNV | Missense_Mutation | novel | c.266C>G | p.Ser89Cys | p.S89C | O14521 | protein_coding | tolerated(0.1) | possibly_damaging(0.797) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
SDHD | SNV | Missense_Mutation | rs201726097 | c.386N>C | p.Leu129Ser | p.L129S | O14521 | protein_coding | tolerated(0.13) | benign(0.159) | TCGA-58-8386-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SDHD | SNV | Missense_Mutation | rs878854595 | c.375N>T | p.Lys125Asn | p.K125N | O14521 | protein_coding | tolerated(0.5) | benign(0.021) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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