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Gene: SCUBE2 |
Gene summary for SCUBE2 |
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Gene information | Species | Human | Gene symbol | SCUBE2 | Gene ID | 57758 |
Gene name | signal peptide, CUB domain and EGF like domain containing 2 | |
Gene Alias | CEGB1 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9NQ36 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57758 | SCUBE2 | GSM4909302 | Human | Breast | IDC | 4.53e-03 | 2.79e-01 | 0.1545 |
57758 | SCUBE2 | GSM4909304 | Human | Breast | IDC | 5.67e-08 | 2.99e-01 | 0.1636 |
57758 | SCUBE2 | GSM4909306 | Human | Breast | IDC | 1.18e-16 | 5.11e-01 | 0.1564 |
57758 | SCUBE2 | GSM4909307 | Human | Breast | IDC | 1.48e-15 | 4.84e-01 | 0.1569 |
57758 | SCUBE2 | GSM4909308 | Human | Breast | IDC | 1.08e-44 | 7.79e-01 | 0.158 |
57758 | SCUBE2 | GSM4909311 | Human | Breast | IDC | 4.55e-02 | 2.03e-01 | 0.1534 |
57758 | SCUBE2 | GSM4909312 | Human | Breast | IDC | 1.59e-06 | 3.43e-01 | 0.1552 |
57758 | SCUBE2 | GSM4909321 | Human | Breast | IDC | 1.02e-03 | 3.02e-01 | 0.1559 |
57758 | SCUBE2 | NCCBC3 | Human | Breast | DCIS | 3.41e-09 | 3.64e-01 | 0.1198 |
57758 | SCUBE2 | P3 | Human | Breast | IDC | 7.78e-16 | 8.94e-01 | 0.1542 |
57758 | SCUBE2 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 4.42e-06 | 3.65e-01 | -0.1688 |
57758 | SCUBE2 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 1.59e-08 | 7.82e-01 | -0.1972 |
57758 | SCUBE2 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 4.36e-23 | 1.04e+00 | -0.2126 |
57758 | SCUBE2 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 2.29e-08 | 6.18e-01 | -0.1833 |
57758 | SCUBE2 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 4.04e-08 | 7.75e-01 | -0.23 |
57758 | SCUBE2 | 047563_1562-all-cells | Human | Prostate | BPH | 4.23e-05 | -1.32e-01 | 0.0791 |
57758 | SCUBE2 | 048752_1579-all-cells | Human | Prostate | BPH | 1.47e-02 | 3.06e-01 | 0.1008 |
57758 | SCUBE2 | 052095_1628-all-cells | Human | Prostate | BPH | 3.66e-19 | 6.50e-01 | 0.1032 |
57758 | SCUBE2 | 052099_1652-all-cells | Human | Prostate | BPH | 2.87e-11 | 4.57e-01 | 0.1038 |
57758 | SCUBE2 | Dong_P1 | Human | Prostate | Tumor | 3.22e-08 | 1.36e-01 | 0.035 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCUBE2 | deletion | Frame_Shift_Del | novel | c.263delN | p.Asp88ValfsTer16 | p.D88Vfs*16 | Q9NQ36 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SCUBE2 | SNV | Missense_Mutation | novel | c.2704N>A | p.Gln902Lys | p.Q902K | Q9NQ36 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SCUBE2 | SNV | Missense_Mutation | c.1077N>T | p.Glu359Asp | p.E359D | Q9NQ36 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SCUBE2 | SNV | Missense_Mutation | c.1538N>A | p.Arg513Gln | p.R513Q | Q9NQ36 | protein_coding | tolerated(0.52) | benign(0.013) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SCUBE2 | SNV | Missense_Mutation | novel | c.1090N>T | p.Asp364Tyr | p.D364Y | Q9NQ36 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SCUBE2 | SNV | Missense_Mutation | c.2398A>G | p.Asn800Asp | p.N800D | Q9NQ36 | protein_coding | tolerated(0.16) | probably_damaging(0.997) | TCGA-AA-3530-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SCUBE2 | SNV | Missense_Mutation | rs138426692 | c.2671N>A | p.Ala891Thr | p.A891T | Q9NQ36 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCUBE2 | SNV | Missense_Mutation | novel | c.2879N>C | p.Val960Ala | p.V960A | Q9NQ36 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCUBE2 | SNV | Missense_Mutation | novel | c.2174N>A | p.Arg725Gln | p.R725Q | Q9NQ36 | protein_coding | tolerated(0.1) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCUBE2 | SNV | Missense_Mutation | novel | c.347G>T | p.Gly116Val | p.G116V | Q9NQ36 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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