![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SCARA3 |
Gene summary for SCARA3 |
![]() |
Gene information | Species | Human | Gene symbol | SCARA3 | Gene ID | 51435 |
Gene name | scavenger receptor class A member 3 | |
Gene Alias | APC7 | |
Cytomap | 8p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6AZY7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51435 | SCARA3 | P1T-E | Human | Esophagus | ESCC | 1.77e-03 | 5.14e-01 | 0.0875 |
51435 | SCARA3 | P2T-E | Human | Esophagus | ESCC | 4.96e-17 | 2.81e-01 | 0.1177 |
51435 | SCARA3 | P4T-E | Human | Esophagus | ESCC | 2.36e-04 | 7.99e-02 | 0.1323 |
51435 | SCARA3 | P8T-E | Human | Esophagus | ESCC | 7.53e-06 | 5.39e-02 | 0.0889 |
51435 | SCARA3 | P9T-E | Human | Esophagus | ESCC | 1.20e-02 | 6.60e-02 | 0.1131 |
51435 | SCARA3 | P10T-E | Human | Esophagus | ESCC | 1.33e-09 | 8.60e-02 | 0.116 |
51435 | SCARA3 | P11T-E | Human | Esophagus | ESCC | 1.77e-03 | 2.60e-01 | 0.1426 |
51435 | SCARA3 | P12T-E | Human | Esophagus | ESCC | 8.92e-04 | 1.15e-02 | 0.1122 |
51435 | SCARA3 | P21T-E | Human | Esophagus | ESCC | 5.14e-07 | 5.74e-02 | 0.1617 |
51435 | SCARA3 | P22T-E | Human | Esophagus | ESCC | 8.94e-04 | -2.73e-02 | 0.1236 |
51435 | SCARA3 | P26T-E | Human | Esophagus | ESCC | 1.11e-04 | -3.83e-02 | 0.1276 |
51435 | SCARA3 | P27T-E | Human | Esophagus | ESCC | 3.17e-05 | -7.78e-02 | 0.1055 |
51435 | SCARA3 | P28T-E | Human | Esophagus | ESCC | 2.74e-09 | 9.96e-02 | 0.1149 |
51435 | SCARA3 | P30T-E | Human | Esophagus | ESCC | 3.79e-05 | 3.52e-01 | 0.137 |
51435 | SCARA3 | P31T-E | Human | Esophagus | ESCC | 3.86e-03 | -1.01e-02 | 0.1251 |
51435 | SCARA3 | P37T-E | Human | Esophagus | ESCC | 4.29e-03 | 1.23e-01 | 0.1371 |
51435 | SCARA3 | P39T-E | Human | Esophagus | ESCC | 5.73e-03 | -5.04e-02 | 0.0894 |
51435 | SCARA3 | P42T-E | Human | Esophagus | ESCC | 3.07e-03 | 3.55e-01 | 0.1175 |
51435 | SCARA3 | P47T-E | Human | Esophagus | ESCC | 1.03e-04 | 5.24e-02 | 0.1067 |
51435 | SCARA3 | P48T-E | Human | Esophagus | ESCC | 3.38e-10 | 1.73e-01 | 0.0959 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:000941113 | Esophagus | ESCC | response to UV | 115/8552 | 149/18723 | 3.29e-15 | 1.93e-13 | 115 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:0009650 | Esophagus | ESCC | UV protection | 12/8552 | 13/18723 | 6.18e-04 | 3.32e-03 | 12 |
GO:0006979113 | Thyroid | PTC | response to oxidative stress | 234/5968 | 446/18723 | 6.97e-20 | 9.77e-18 | 234 |
GO:0009314111 | Thyroid | PTC | response to radiation | 195/5968 | 456/18723 | 5.10e-07 | 8.27e-06 | 195 |
GO:00094117 | Thyroid | PTC | response to UV | 76/5968 | 149/18723 | 8.97e-07 | 1.36e-05 | 76 |
GO:00094167 | Thyroid | PTC | response to light stimulus | 127/5968 | 320/18723 | 1.76e-03 | 9.58e-03 | 127 |
GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
GO:000941115 | Thyroid | ATC | response to UV | 84/6293 | 149/18723 | 8.97e-09 | 1.90e-07 | 84 |
GO:000931426 | Thyroid | ATC | response to radiation | 210/6293 | 456/18723 | 1.69e-08 | 3.39e-07 | 210 |
GO:000941613 | Thyroid | ATC | response to light stimulus | 139/6293 | 320/18723 | 1.42e-04 | 9.88e-04 | 139 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCARA3 | SNV | Missense_Mutation | rs773830788 | c.131G>A | p.Arg44His | p.R44H | Q6AZY7 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SCARA3 | SNV | Missense_Mutation | rs757129937 | c.1003N>A | p.Ala335Thr | p.A335T | Q6AZY7 | protein_coding | tolerated(0.54) | benign(0.261) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCARA3 | SNV | Missense_Mutation | rs201948380 | c.1459N>A | p.Gly487Ser | p.G487S | Q6AZY7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SCARA3 | SNV | Missense_Mutation | novel | c.1815C>A | p.Phe605Leu | p.F605L | Q6AZY7 | protein_coding | tolerated_low_confidence(0.98) | benign(0) | TCGA-SS-A7HO-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | PD |
SCARA3 | SNV | Missense_Mutation | rs555402223 | c.253N>A | p.Glu85Lys | p.E85K | Q6AZY7 | protein_coding | tolerated(0.21) | possibly_damaging(0.469) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCARA3 | SNV | Missense_Mutation | rs747823707 | c.292N>T | p.Leu98Phe | p.L98F | Q6AZY7 | protein_coding | deleterious(0.01) | benign(0.224) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCARA3 | SNV | Missense_Mutation | c.573G>T | p.Gln191His | p.Q191H | Q6AZY7 | protein_coding | deleterious(0.04) | possibly_damaging(0.896) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCARA3 | SNV | Missense_Mutation | c.488C>G | p.Thr163Ser | p.T163S | Q6AZY7 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCARA3 | SNV | Missense_Mutation | rs757420816 | c.790G>A | p.Gly264Ser | p.G264S | Q6AZY7 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCARA3 | SNV | Missense_Mutation | novel | c.1768C>T | p.Pro590Ser | p.P590S | Q6AZY7 | protein_coding | deleterious(0.01) | benign(0.196) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |