Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SCAF4_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SCAF4_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SCAF4_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:00432446 | Esophagus | ESCC | regulation of protein-containing complex disassembly | 75/8552 | 121/18723 | 2.17e-04 | 1.36e-03 | 75 |
GO:00063532 | Esophagus | ESCC | DNA-templated transcription, termination | 15/8552 | 21/18723 | 1.54e-02 | 4.96e-02 | 15 |
GO:00432422 | Lung | IAC | negative regulation of protein-containing complex disassembly | 19/2061 | 82/18723 | 1.23e-03 | 1.42e-02 | 19 |
GO:00224118 | Lung | IAC | cellular component disassembly | 68/2061 | 443/18723 | 2.89e-03 | 2.60e-02 | 68 |
GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
GO:003298410 | Oral cavity | OSCC | protein-containing complex disassembly | 136/7305 | 224/18723 | 3.42e-11 | 1.13e-09 | 136 |
GO:00432445 | Oral cavity | OSCC | regulation of protein-containing complex disassembly | 65/7305 | 121/18723 | 7.08e-04 | 3.90e-03 | 65 |
GO:002241121 | Oral cavity | EOLP | cellular component disassembly | 94/2218 | 443/18723 | 1.00e-08 | 4.89e-07 | 94 |
GO:003298421 | Oral cavity | EOLP | protein-containing complex disassembly | 48/2218 | 224/18723 | 3.01e-05 | 4.30e-04 | 48 |
GO:004324411 | Oral cavity | EOLP | regulation of protein-containing complex disassembly | 24/2218 | 121/18723 | 7.53e-03 | 3.62e-02 | 24 |
GO:002241131 | Oral cavity | NEOLP | cellular component disassembly | 87/2005 | 443/18723 | 1.39e-08 | 6.46e-07 | 87 |
GO:004324421 | Oral cavity | NEOLP | regulation of protein-containing complex disassembly | 29/2005 | 121/18723 | 2.33e-05 | 3.72e-04 | 29 |
GO:003298431 | Oral cavity | NEOLP | protein-containing complex disassembly | 45/2005 | 224/18723 | 2.33e-05 | 3.72e-04 | 45 |
GO:00432423 | Oral cavity | NEOLP | negative regulation of protein-containing complex disassembly | 18/2005 | 82/18723 | 2.28e-03 | 1.47e-02 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCAF4 | insertion | Nonsense_Mutation | novel | c.211_212insCATATATATAATAT | p.Arg71ProfsTer4 | p.R71Pfs*4 | O95104 | protein_coding | | | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SCAF4 | insertion | Frame_Shift_Ins | novel | c.3361_3362insAG | p.Pro1121GlnfsTer34 | p.P1121Qfs*34 | O95104 | protein_coding | | | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SCAF4 | insertion | Frame_Shift_Ins | novel | c.3360_3361insATGCTGTATTATATCCGCTCCCGCTGTACTG | p.Pro1121MetfsTer13 | p.P1121Mfs*13 | O95104 | protein_coding | | | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SCAF4 | SNV | Missense_Mutation | novel | c.1078N>T | p.Pro360Ser | p.P360S | O95104 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SCAF4 | SNV | Missense_Mutation | novel | c.1912N>A | p.Glu638Lys | p.E638K | O95104 | protein_coding | tolerated(0.14) | benign(0.091) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SCAF4 | SNV | Missense_Mutation | | c.1343N>G | p.Ser448Cys | p.S448C | O95104 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SCAF4 | SNV | Missense_Mutation | novel | c.1307N>G | p.Ser436Cys | p.S436C | O95104 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
SCAF4 | SNV | Missense_Mutation | | c.1501N>A | p.Glu501Lys | p.E501K | O95104 | protein_coding | tolerated(0.35) | possibly_damaging(0.787) | TCGA-MU-A5YI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
SCAF4 | insertion | Frame_Shift_Ins | novel | c.632_633insAGAAGTGATAATT | p.Pro212GlufsTer13 | p.P212Efs*13 | O95104 | protein_coding | | | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
SCAF4 | SNV | Missense_Mutation | novel | c.182N>T | p.Pro61Leu | p.P61L | O95104 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5M-AATE-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |