![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: S1PR5 |
Gene summary for S1PR5 |
![]() |
Gene information | Species | Human | Gene symbol | S1PR5 | Gene ID | 53637 |
Gene name | sphingosine-1-phosphate receptor 5 | |
Gene Alias | EDG8 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0003376 | UniProtAcc | Q9H228 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
53637 | S1PR5 | LZE4T | Human | Esophagus | ESCC | 3.86e-11 | 2.87e-01 | 0.0811 |
53637 | S1PR5 | P2T-E | Human | Esophagus | ESCC | 1.66e-02 | 9.52e-02 | 0.1177 |
53637 | S1PR5 | P4T-E | Human | Esophagus | ESCC | 3.18e-14 | 2.92e-01 | 0.1323 |
53637 | S1PR5 | P5T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.16e-01 | 0.1327 |
53637 | S1PR5 | P10T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.42e-01 | 0.116 |
53637 | S1PR5 | P12T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.94e-01 | 0.1122 |
53637 | S1PR5 | P15T-E | Human | Esophagus | ESCC | 9.35e-25 | 4.46e-01 | 0.1149 |
53637 | S1PR5 | P16T-E | Human | Esophagus | ESCC | 3.97e-04 | 6.96e-02 | 0.1153 |
53637 | S1PR5 | P20T-E | Human | Esophagus | ESCC | 4.38e-08 | 1.84e-01 | 0.1124 |
53637 | S1PR5 | P21T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.54e-01 | 0.1617 |
53637 | S1PR5 | P22T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.75e-01 | 0.1236 |
53637 | S1PR5 | P23T-E | Human | Esophagus | ESCC | 1.99e-08 | 2.71e-01 | 0.108 |
53637 | S1PR5 | P24T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.11e-01 | 0.1287 |
53637 | S1PR5 | P26T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.00e-01 | 0.1276 |
53637 | S1PR5 | P27T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.37e-01 | 0.1055 |
53637 | S1PR5 | P28T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.26e-01 | 0.1149 |
53637 | S1PR5 | P30T-E | Human | Esophagus | ESCC | 4.37e-20 | 4.60e-01 | 0.137 |
53637 | S1PR5 | P31T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.91e-01 | 0.1251 |
53637 | S1PR5 | P32T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.50e-01 | 0.1666 |
53637 | S1PR5 | P36T-E | Human | Esophagus | ESCC | 1.14e-17 | 5.91e-01 | 0.1187 |
Page: 1 2 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0407116 | Esophagus | ESCC | Sphingolipid signaling pathway | 85/4205 | 121/8465 | 3.04e-06 | 1.73e-05 | 8.84e-06 | 85 |
hsa0407117 | Esophagus | ESCC | Sphingolipid signaling pathway | 85/4205 | 121/8465 | 3.04e-06 | 1.73e-05 | 8.84e-06 | 85 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S1PR5 | SNV | Missense_Mutation | c.842N>T | p.Thr281Ile | p.T281I | Q9H228 | protein_coding | tolerated(0.06) | benign(0.026) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S1PR5 | SNV | Missense_Mutation | c.271N>A | p.Ala91Thr | p.A91T | Q9H228 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
S1PR5 | SNV | Missense_Mutation | novel | c.323G>T | p.Trp108Leu | p.W108L | Q9H228 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S1PR5 | SNV | Missense_Mutation | novel | c.275N>C | p.Asn92Thr | p.N92T | Q9H228 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
S1PR5 | SNV | Missense_Mutation | c.159G>T | p.Glu53Asp | p.E53D | Q9H228 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
S1PR5 | SNV | Missense_Mutation | c.1189G>A | p.Ala397Thr | p.A397T | Q9H228 | protein_coding | tolerated_low_confidence(0.15) | benign(0) | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
S1PR5 | SNV | Missense_Mutation | rs763804506 | c.830G>A | p.Cys277Tyr | p.C277Y | Q9H228 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-D1-A17A-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S1PR5 | SNV | Missense_Mutation | c.271G>A | p.Ala91Thr | p.A91T | Q9H228 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S1PR5 | SNV | Missense_Mutation | novel | c.226N>A | p.Gly76Ser | p.G76S | Q9H228 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
S1PR5 | SNV | Missense_Mutation | c.1087N>A | p.Ser363Thr | p.S363T | Q9H228 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-ED-A7PZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 318164808 | SIPONIMOD | |
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 318164850 | ETRASIMOD | |
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 329968432 | ||
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | CHEMBL2336071 | SIPONIMOD | |
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | CHEMBL544665 | FINGOLIMOD HYDROCHLORIDE | |
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 252827367 | OZANIMOD | |
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | ASP-4058 | ASP-4058 | ||
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135649899 | ||
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135649942 | ||
53637 | S1PR5 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651310 |
Page: 1 2 |