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Gene: RUNDC3B |
Gene summary for RUNDC3B |
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Gene information | Species | Human | Gene symbol | RUNDC3B | Gene ID | 154661 |
Gene name | RUN domain containing 3B | |
Gene Alias | RPIB9 | |
Cytomap | 7q21.12 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96NL0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
154661 | RUNDC3B | AEH-subject5 | Human | Endometrium | AEH | 4.62e-05 | 2.06e-01 | -0.2953 |
154661 | RUNDC3B | EEC-subject4 | Human | Endometrium | EEC | 8.25e-04 | 1.51e-01 | -0.2571 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUNDC3B | SNV | Missense_Mutation | rs557040251 | c.1225N>A | p.Gln409Lys | p.Q409K | Q96NL0 | protein_coding | tolerated(0.94) | benign(0.017) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RUNDC3B | SNV | Missense_Mutation | c.941N>T | p.Ser314Phe | p.S314F | Q96NL0 | protein_coding | tolerated(0.72) | benign(0.091) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
RUNDC3B | SNV | Missense_Mutation | novel | c.872N>T | p.Arg291Leu | p.R291L | Q96NL0 | protein_coding | deleterious(0) | possibly_damaging(0.749) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUNDC3B | SNV | Missense_Mutation | c.1260N>C | p.Leu420Phe | p.L420F | Q96NL0 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RUNDC3B | deletion | Frame_Shift_Del | c.23delG | p.Gly8AlafsTer2 | p.G8Afs*2 | Q96NL0 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
RUNDC3B | SNV | Missense_Mutation | rs760764597 | c.943G>A | p.Asp315Asn | p.D315N | Q96NL0 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RUNDC3B | SNV | Missense_Mutation | novel | c.461A>G | p.His154Arg | p.H154R | Q96NL0 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RUNDC3B | SNV | Missense_Mutation | novel | c.1313G>T | p.Gly438Val | p.G438V | Q96NL0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RUNDC3B | SNV | Missense_Mutation | novel | c.1219C>T | p.Pro407Ser | p.P407S | Q96NL0 | protein_coding | tolerated(0.21) | benign(0.165) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUNDC3B | SNV | Missense_Mutation | c.448N>T | p.Leu150Phe | p.L150F | Q96NL0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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