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Gene: RSRP1 |
Gene summary for RSRP1 |
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Gene information | Species | Human | Gene symbol | RSRP1 | Gene ID | 57035 |
Gene name | arginine and serine rich protein 1 | |
Gene Alias | C1orf63 | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024RAH6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57035 | RSRP1 | GSM4909282 | Human | Breast | IDC | 1.47e-03 | -3.29e-01 | -0.0288 |
57035 | RSRP1 | GSM4909291 | Human | Breast | IDC | 5.12e-07 | -5.00e-01 | 0.1753 |
57035 | RSRP1 | GSM4909294 | Human | Breast | IDC | 4.11e-09 | -4.31e-01 | 0.2022 |
57035 | RSRP1 | GSM4909296 | Human | Breast | IDC | 3.82e-18 | -4.64e-01 | 0.1524 |
57035 | RSRP1 | GSM4909297 | Human | Breast | IDC | 9.31e-15 | -1.82e-01 | 0.1517 |
57035 | RSRP1 | GSM4909301 | Human | Breast | IDC | 1.20e-05 | -4.21e-01 | 0.1577 |
57035 | RSRP1 | GSM4909306 | Human | Breast | IDC | 9.62e-07 | -4.12e-01 | 0.1564 |
57035 | RSRP1 | GSM4909307 | Human | Breast | IDC | 2.21e-06 | -3.78e-01 | 0.1569 |
57035 | RSRP1 | GSM4909309 | Human | Breast | IDC | 2.28e-05 | -3.63e-01 | 0.0483 |
57035 | RSRP1 | GSM4909311 | Human | Breast | IDC | 5.25e-40 | -6.50e-01 | 0.1534 |
57035 | RSRP1 | GSM4909312 | Human | Breast | IDC | 6.13e-26 | -5.86e-01 | 0.1552 |
57035 | RSRP1 | GSM4909313 | Human | Breast | IDC | 9.11e-04 | -3.46e-01 | 0.0391 |
57035 | RSRP1 | GSM4909315 | Human | Breast | IDC | 8.16e-07 | -4.30e-01 | 0.21 |
57035 | RSRP1 | GSM4909316 | Human | Breast | IDC | 1.58e-04 | -4.97e-01 | 0.21 |
57035 | RSRP1 | GSM4909319 | Human | Breast | IDC | 5.77e-36 | -5.77e-01 | 0.1563 |
57035 | RSRP1 | GSM4909320 | Human | Breast | IDC | 1.83e-09 | -4.26e-01 | 0.1575 |
57035 | RSRP1 | GSM4909321 | Human | Breast | IDC | 3.38e-13 | -3.08e-01 | 0.1559 |
57035 | RSRP1 | brca1 | Human | Breast | Precancer | 1.06e-02 | -3.49e-01 | -0.0338 |
57035 | RSRP1 | brca10 | Human | Breast | Precancer | 1.65e-09 | -4.90e-01 | -0.0029 |
57035 | RSRP1 | M2 | Human | Breast | IDC | 3.84e-03 | -5.74e-01 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSRP1 | SNV | Missense_Mutation | novel | c.755A>T | p.Asn252Ile | p.N252I | Q9BUV0 | protein_coding | deleterious(0) | possibly_damaging(0.684) | TCGA-AX-A3FX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
RSRP1 | deletion | Frame_Shift_Del | novel | c.829delN | p.Ile277Ter | p.I277* | Q9BUV0 | protein_coding | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RSRP1 | SNV | Missense_Mutation | novel | c.344C>G | p.Ser115Cys | p.S115C | Q9BUV0 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD |
RSRP1 | SNV | Missense_Mutation | c.500N>T | p.Pro167Leu | p.P167L | Q9BUV0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RSRP1 | SNV | Missense_Mutation | novel | c.322C>T | p.Pro108Ser | p.P108S | Q9BUV0 | protein_coding | tolerated(0.27) | benign(0.217) | TCGA-NC-A5HQ-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
RSRP1 | SNV | Missense_Mutation | novel | c.26G>T | p.Trp9Leu | p.W9L | Q9BUV0 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.784) | TCGA-CV-7242-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSRP1 | SNV | Missense_Mutation | rs750442247 | c.316N>T | p.Arg106Trp | p.R106W | Q9BUV0 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-CV-7253-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RSRP1 | SNV | Missense_Mutation | c.596N>A | p.Ala199Asp | p.A199D | Q9BUV0 | protein_coding | deleterious(0.03) | probably_damaging(0.925) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RSRP1 | deletion | In_Frame_Del | rs774170122 | c.43_45delNNN | p.Glu15del | p.E15del | Q9BUV0 | protein_coding | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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