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Gene: RSPH9 |
Gene summary for RSPH9 |
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Gene information | Species | Human | Gene symbol | RSPH9 | Gene ID | 221421 |
Gene name | radial spoke head component 9 | |
Gene Alias | C6orf206 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q9H1X1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221421 | RSPH9 | ATC13 | Human | Thyroid | ATC | 2.27e-33 | 7.91e-01 | 0.34 |
221421 | RSPH9 | ATC5 | Human | Thyroid | ATC | 1.15e-38 | 8.31e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSPH9 | SNV | Missense_Mutation | rs768448558 | c.293T>C | p.Val98Ala | p.V98A | Q9H1X1 | protein_coding | tolerated(0.16) | benign(0.195) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
RSPH9 | SNV | Missense_Mutation | rs142194323 | c.281N>T | p.Ala94Val | p.A94V | Q9H1X1 | protein_coding | tolerated(0.36) | benign(0.001) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RSPH9 | SNV | Missense_Mutation | rs769469438 | c.787N>A | p.Gly263Arg | p.G263R | Q9H1X1 | protein_coding | tolerated_low_confidence(0.99) | benign(0.003) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSPH9 | SNV | Missense_Mutation | c.914N>A | p.Arg305Lys | p.R305K | Q9H1X1 | protein_coding | tolerated_low_confidence(0.92) | benign(0.001) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RSPH9 | SNV | Missense_Mutation | novel | c.236N>A | p.Cys79Tyr | p.C79Y | Q9H1X1 | protein_coding | deleterious(0.02) | benign(0.359) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSPH9 | SNV | Missense_Mutation | c.8N>T | p.Ala3Val | p.A3V | Q9H1X1 | protein_coding | tolerated(0.08) | benign(0.087) | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RSPH9 | SNV | Missense_Mutation | novel | c.110G>A | p.Arg37His | p.R37H | Q9H1X1 | protein_coding | tolerated(0.15) | benign(0.018) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
RSPH9 | SNV | Missense_Mutation | c.397G>A | p.Asp133Asn | p.D133N | Q9H1X1 | protein_coding | tolerated(0.06) | possibly_damaging(0.902) | TCGA-BG-A0M3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RSPH9 | SNV | Missense_Mutation | novel | c.173N>G | p.Tyr58Cys | p.Y58C | Q9H1X1 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
RSPH9 | SNV | Missense_Mutation | rs147146440 | c.427N>A | p.Ala143Thr | p.A143T | Q9H1X1 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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