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Gene: RPS6KC1 |
Gene summary for RPS6KC1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RPS6KC1 | Gene ID | 26750 |
Gene name | ribosomal protein S6 kinase C1 | |
Gene Alias | RPK118 | |
Cytomap | 1q32.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96S38 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26750 | RPS6KC1 | CCI_1 | Human | Cervix | CC | 4.83e-09 | 1.07e+00 | 0.528 |
26750 | RPS6KC1 | CCI_2 | Human | Cervix | CC | 3.31e-04 | 5.06e-01 | 0.5249 |
26750 | RPS6KC1 | CCI_3 | Human | Cervix | CC | 4.90e-11 | 8.15e-01 | 0.516 |
26750 | RPS6KC1 | LZE4T | Human | Esophagus | ESCC | 2.21e-08 | 3.07e-01 | 0.0811 |
26750 | RPS6KC1 | LZE7T | Human | Esophagus | ESCC | 2.67e-07 | 2.56e-01 | 0.0667 |
26750 | RPS6KC1 | LZE24T | Human | Esophagus | ESCC | 2.21e-05 | 1.39e-01 | 0.0596 |
26750 | RPS6KC1 | LZE21T | Human | Esophagus | ESCC | 4.27e-04 | 2.66e-01 | 0.0655 |
26750 | RPS6KC1 | P1T-E | Human | Esophagus | ESCC | 2.08e-02 | 1.93e-01 | 0.0875 |
26750 | RPS6KC1 | P2T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.65e-01 | 0.1177 |
26750 | RPS6KC1 | P4T-E | Human | Esophagus | ESCC | 8.30e-03 | 1.19e-01 | 0.1323 |
26750 | RPS6KC1 | P5T-E | Human | Esophagus | ESCC | 1.13e-10 | 2.24e-01 | 0.1327 |
26750 | RPS6KC1 | P8T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.01e-01 | 0.0889 |
26750 | RPS6KC1 | P9T-E | Human | Esophagus | ESCC | 1.01e-13 | 3.57e-01 | 0.1131 |
26750 | RPS6KC1 | P10T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.90e-01 | 0.116 |
26750 | RPS6KC1 | P11T-E | Human | Esophagus | ESCC | 1.85e-10 | 3.92e-01 | 0.1426 |
26750 | RPS6KC1 | P12T-E | Human | Esophagus | ESCC | 2.56e-16 | 2.94e-01 | 0.1122 |
26750 | RPS6KC1 | P15T-E | Human | Esophagus | ESCC | 9.37e-13 | 3.05e-01 | 0.1149 |
26750 | RPS6KC1 | P16T-E | Human | Esophagus | ESCC | 6.17e-12 | 3.50e-01 | 0.1153 |
26750 | RPS6KC1 | P17T-E | Human | Esophagus | ESCC | 1.36e-02 | 1.47e-01 | 0.1278 |
26750 | RPS6KC1 | P19T-E | Human | Esophagus | ESCC | 1.67e-04 | 3.35e-01 | 0.1662 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS6KC1 | SNV | Missense_Mutation | c.497T>C | p.Val166Ala | p.V166A | Q96S38 | protein_coding | tolerated(0.26) | benign(0.013) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KC1 | SNV | Missense_Mutation | novel | c.1861N>A | p.Leu621Met | p.L621M | Q96S38 | protein_coding | tolerated(0.08) | benign(0.046) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS6KC1 | SNV | Missense_Mutation | c.1510T>G | p.Ser504Ala | p.S504A | Q96S38 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KC1 | SNV | Missense_Mutation | c.1228N>A | p.Gly410Ser | p.G410S | Q96S38 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RPS6KC1 | SNV | Missense_Mutation | c.1060N>A | p.Asp354Asn | p.D354N | Q96S38 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RPS6KC1 | SNV | Missense_Mutation | novel | c.2060N>A | p.Gly687Glu | p.G687E | Q96S38 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RPS6KC1 | SNV | Missense_Mutation | c.430N>G | p.Ser144Ala | p.S144A | Q96S38 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KC1 | SNV | Missense_Mutation | c.2902T>G | p.Cys968Gly | p.C968G | Q96S38 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RPS6KC1 | SNV | Missense_Mutation | c.511G>T | p.Asp171Tyr | p.D171Y | Q96S38 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-D5-6533-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | oxaliplatin | CR | |
RPS6KC1 | SNV | Missense_Mutation | novel | c.364G>C | p.Glu122Gln | p.E122Q | Q96S38 | protein_coding | tolerated(0.55) | benign(0.015) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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