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Gene: RPAIN |
Gene summary for RPAIN |
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Gene information | Species | Human | Gene symbol | RPAIN | Gene ID | 84268 |
Gene name | RPA interacting protein | |
Gene Alias | HRIP | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0B4J1T3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84268 | RPAIN | AEH-subject1 | Human | Endometrium | AEH | 4.89e-06 | -1.96e-01 | -0.3059 |
84268 | RPAIN | AEH-subject2 | Human | Endometrium | AEH | 1.23e-09 | -2.33e-01 | -0.2525 |
84268 | RPAIN | AEH-subject3 | Human | Endometrium | AEH | 7.55e-10 | -2.69e-01 | -0.2576 |
84268 | RPAIN | EEC-subject1 | Human | Endometrium | EEC | 1.76e-08 | -1.96e-01 | -0.2682 |
84268 | RPAIN | EEC-subject2 | Human | Endometrium | EEC | 1.09e-11 | -2.85e-01 | -0.2607 |
84268 | RPAIN | EEC-subject3 | Human | Endometrium | EEC | 1.90e-34 | -3.24e-01 | -0.2525 |
84268 | RPAIN | EEC-subject5 | Human | Endometrium | EEC | 1.34e-04 | -2.05e-01 | -0.249 |
84268 | RPAIN | GSM5276934 | Human | Endometrium | EEC | 5.87e-04 | -2.11e-01 | -0.0913 |
84268 | RPAIN | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.89e-24 | -1.64e-01 | -0.1869 |
84268 | RPAIN | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.00e-21 | -1.58e-01 | -0.1875 |
84268 | RPAIN | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 9.61e-30 | -1.64e-01 | -0.1883 |
84268 | RPAIN | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 9.62e-28 | -2.13e-01 | -0.1934 |
84268 | RPAIN | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 4.31e-46 | -1.51e-01 | -0.1917 |
84268 | RPAIN | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 6.90e-44 | -5.60e-02 | -0.1916 |
84268 | RPAIN | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 7.31e-05 | 2.03e-02 | -0.1269 |
84268 | RPAIN | LZE3D | Human | Esophagus | HGIN | 4.22e-03 | 4.81e-01 | 0.0668 |
84268 | RPAIN | LZE4T | Human | Esophagus | ESCC | 2.31e-13 | 5.90e-01 | 0.0811 |
84268 | RPAIN | LZE7T | Human | Esophagus | ESCC | 2.61e-17 | 1.62e+00 | 0.0667 |
84268 | RPAIN | LZE8T | Human | Esophagus | ESCC | 6.04e-08 | 2.92e-01 | 0.067 |
84268 | RPAIN | LZE20T | Human | Esophagus | ESCC | 1.19e-04 | 6.73e-02 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007259410 | Endometrium | AEH | establishment of protein localization to organelle | 89/2100 | 422/18723 | 2.41e-09 | 1.90e-07 | 89 |
GO:00345049 | Endometrium | AEH | protein localization to nucleus | 57/2100 | 290/18723 | 1.65e-05 | 3.42e-04 | 57 |
GO:000691310 | Endometrium | AEH | nucleocytoplasmic transport | 54/2100 | 301/18723 | 3.24e-04 | 3.62e-03 | 54 |
GO:005116910 | Endometrium | AEH | nuclear transport | 54/2100 | 301/18723 | 3.24e-04 | 3.62e-03 | 54 |
GO:00170389 | Endometrium | AEH | protein import | 37/2100 | 206/18723 | 2.56e-03 | 1.89e-02 | 37 |
GO:007259415 | Endometrium | EEC | establishment of protein localization to organelle | 94/2168 | 422/18723 | 2.22e-10 | 2.51e-08 | 94 |
GO:003450413 | Endometrium | EEC | protein localization to nucleus | 60/2168 | 290/18723 | 5.09e-06 | 1.26e-04 | 60 |
GO:000691314 | Endometrium | EEC | nucleocytoplasmic transport | 59/2168 | 301/18723 | 3.31e-05 | 5.65e-04 | 59 |
GO:005116914 | Endometrium | EEC | nuclear transport | 59/2168 | 301/18723 | 3.31e-05 | 5.65e-04 | 59 |
GO:001703813 | Endometrium | EEC | protein import | 40/2168 | 206/18723 | 6.94e-04 | 6.66e-03 | 40 |
GO:007259420 | Esophagus | HGIN | establishment of protein localization to organelle | 120/2587 | 422/18723 | 1.73e-15 | 4.00e-13 | 120 |
GO:003450417 | Esophagus | HGIN | protein localization to nucleus | 84/2587 | 290/18723 | 1.06e-11 | 1.24e-09 | 84 |
GO:000691319 | Esophagus | HGIN | nucleocytoplasmic transport | 83/2587 | 301/18723 | 2.14e-10 | 1.97e-08 | 83 |
GO:005116919 | Esophagus | HGIN | nuclear transport | 83/2587 | 301/18723 | 2.14e-10 | 1.97e-08 | 83 |
GO:001703817 | Esophagus | HGIN | protein import | 51/2587 | 206/18723 | 1.79e-05 | 4.86e-04 | 51 |
GO:005117010 | Esophagus | HGIN | import into nucleus | 41/2587 | 159/18723 | 4.24e-05 | 1.04e-03 | 41 |
GO:000660610 | Esophagus | HGIN | protein import into nucleus | 39/2587 | 155/18723 | 1.14e-04 | 2.39e-03 | 39 |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPAIN | SNV | Missense_Mutation | novel | c.611N>A | p.Ser204Asn | p.S204N | protein_coding | tolerated(0.51) | benign(0.04) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPAIN | SNV | Missense_Mutation | novel | c.577N>A | p.Phe193Ile | p.F193I | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
RPAIN | SNV | Missense_Mutation | c.194N>A | p.Met65Lys | p.M65K | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-05-4434-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
RPAIN | SNV | Missense_Mutation | novel | c.342N>C | p.Lys114Asn | p.K114N | protein_coding | tolerated(0.11) | benign(0.211) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPAIN | SNV | Missense_Mutation | novel | c.387N>C | p.Glu129Asp | p.E129D | protein_coding | tolerated(0.48) | possibly_damaging(0.517) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RPAIN | insertion | In_Frame_Ins | novel | c.619_620insGTGACT | p.Met207delinsSerAspLeu | p.M207delinsSDL | protein_coding | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
RPAIN | SNV | Missense_Mutation | novel | c.61N>C | p.Trp21Arg | p.W21R | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-7254-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
RPAIN | SNV | Missense_Mutation | novel | c.62N>T | p.Trp21Leu | p.W21L | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CV-7254-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
RPAIN | SNV | Missense_Mutation | novel | c.485C>T | p.Ser162Phe | p.S162F | protein_coding | deleterious(0.05) | benign(0.086) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RPAIN | SNV | Missense_Mutation | novel | c.686N>C | p.Phe229Ser | p.F229S | protein_coding | deleterious_low_confidence(0.02) | benign(0.01) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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