![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RNF220 |
Gene summary for RNF220 |
![]() |
Gene information | Species | Human | Gene symbol | RNF220 | Gene ID | 55182 |
Gene name | ring finger protein 220 | |
Gene Alias | C1orf164 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0003002 | UniProtAcc | Q5VTB9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55182 | RNF220 | LZE4T | Human | Esophagus | ESCC | 2.14e-05 | 1.20e-01 | 0.0811 |
55182 | RNF220 | LZE7T | Human | Esophagus | ESCC | 3.65e-11 | 6.71e-01 | 0.0667 |
55182 | RNF220 | LZE24T | Human | Esophagus | ESCC | 2.27e-08 | 2.77e-01 | 0.0596 |
55182 | RNF220 | LZE21T | Human | Esophagus | ESCC | 6.43e-05 | 2.91e-01 | 0.0655 |
55182 | RNF220 | P2T-E | Human | Esophagus | ESCC | 1.52e-29 | 5.46e-01 | 0.1177 |
55182 | RNF220 | P4T-E | Human | Esophagus | ESCC | 2.03e-16 | 4.17e-01 | 0.1323 |
55182 | RNF220 | P5T-E | Human | Esophagus | ESCC | 1.96e-29 | 4.95e-01 | 0.1327 |
55182 | RNF220 | P8T-E | Human | Esophagus | ESCC | 8.73e-12 | 2.62e-01 | 0.0889 |
55182 | RNF220 | P9T-E | Human | Esophagus | ESCC | 1.17e-14 | 2.13e-01 | 0.1131 |
55182 | RNF220 | P10T-E | Human | Esophagus | ESCC | 1.20e-37 | 6.15e-01 | 0.116 |
55182 | RNF220 | P11T-E | Human | Esophagus | ESCC | 2.47e-03 | 2.27e-01 | 0.1426 |
55182 | RNF220 | P12T-E | Human | Esophagus | ESCC | 7.42e-08 | 1.52e-01 | 0.1122 |
55182 | RNF220 | P15T-E | Human | Esophagus | ESCC | 5.84e-12 | 2.63e-01 | 0.1149 |
55182 | RNF220 | P16T-E | Human | Esophagus | ESCC | 9.67e-11 | 1.18e-01 | 0.1153 |
55182 | RNF220 | P17T-E | Human | Esophagus | ESCC | 8.63e-03 | 1.21e-01 | 0.1278 |
55182 | RNF220 | P20T-E | Human | Esophagus | ESCC | 8.84e-09 | 1.43e-01 | 0.1124 |
55182 | RNF220 | P21T-E | Human | Esophagus | ESCC | 4.17e-24 | 3.91e-01 | 0.1617 |
55182 | RNF220 | P22T-E | Human | Esophagus | ESCC | 2.61e-17 | 1.21e-01 | 0.1236 |
55182 | RNF220 | P23T-E | Human | Esophagus | ESCC | 2.57e-21 | 3.54e-01 | 0.108 |
55182 | RNF220 | P24T-E | Human | Esophagus | ESCC | 1.53e-12 | 1.48e-01 | 0.1287 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:00219159 | Esophagus | ESCC | neural tube development | 101/8552 | 152/18723 | 1.78e-07 | 2.79e-06 | 101 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:009026316 | Esophagus | ESCC | positive regulation of canonical Wnt signaling pathway | 69/8552 | 106/18723 | 4.22e-05 | 3.39e-04 | 69 |
GO:003017716 | Esophagus | ESCC | positive regulation of Wnt signaling pathway | 87/8552 | 140/18723 | 6.18e-05 | 4.73e-04 | 87 |
GO:00518658 | Esophagus | ESCC | protein autoubiquitination | 47/8552 | 73/18723 | 9.72e-04 | 4.93e-03 | 47 |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:006007021 | Liver | HCC | canonical Wnt signaling pathway | 162/7958 | 303/18723 | 7.00e-05 | 6.32e-04 | 162 |
GO:006082821 | Liver | HCC | regulation of canonical Wnt signaling pathway | 137/7958 | 253/18723 | 1.15e-04 | 9.70e-04 | 137 |
GO:003017721 | Liver | HCC | positive regulation of Wnt signaling pathway | 81/7958 | 140/18723 | 1.73e-04 | 1.36e-03 | 81 |
GO:009026321 | Liver | HCC | positive regulation of canonical Wnt signaling pathway | 62/7958 | 106/18723 | 6.44e-04 | 3.99e-03 | 62 |
GO:00219154 | Liver | HCC | neural tube development | 82/7958 | 152/18723 | 2.83e-03 | 1.33e-02 | 82 |
GO:00518654 | Liver | HCC | protein autoubiquitination | 42/7958 | 73/18723 | 6.78e-03 | 2.73e-02 | 42 |
GO:001605510 | Oral cavity | OSCC | Wnt signaling pathway | 227/7305 | 444/18723 | 1.10e-07 | 1.87e-06 | 227 |
GO:019873810 | Oral cavity | OSCC | cell-cell signaling by wnt | 227/7305 | 446/18723 | 1.75e-07 | 2.86e-06 | 227 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF220 | SNV | Missense_Mutation | novel | c.1570N>T | p.Pro524Ser | p.P524S | Q5VTB9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF220 | SNV | Missense_Mutation | c.613C>T | p.Arg205Trp | p.R205W | Q5VTB9 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RNF220 | SNV | Missense_Mutation | c.1096G>A | p.Ala366Thr | p.A366T | Q5VTB9 | protein_coding | tolerated(0.07) | probably_damaging(0.956) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RNF220 | SNV | Missense_Mutation | c.816N>C | p.Leu272Phe | p.L272F | Q5VTB9 | protein_coding | tolerated(0.23) | probably_damaging(0.969) | TCGA-DM-A1D0-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNF220 | SNV | Missense_Mutation | rs764633164 | c.410N>T | p.Thr137Met | p.T137M | Q5VTB9 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-F4-6461-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
RNF220 | SNV | Missense_Mutation | c.1597N>A | p.Val533Met | p.V533M | Q5VTB9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNF220 | SNV | Missense_Mutation | c.350N>G | p.Val117Gly | p.V117G | Q5VTB9 | protein_coding | deleterious(0.04) | probably_damaging(0.95) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RNF220 | SNV | Missense_Mutation | rs374722047 | c.641N>T | p.Ala214Val | p.A214V | Q5VTB9 | protein_coding | tolerated(0.93) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RNF220 | SNV | Missense_Mutation | novel | c.978N>T | p.Lys326Asn | p.K326N | Q5VTB9 | protein_coding | deleterious(0.03) | probably_damaging(0.966) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RNF220 | SNV | Missense_Mutation | novel | c.284T>C | p.Leu95Pro | p.L95P | Q5VTB9 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |