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Gene: RNASE4 |
Gene summary for RNASE4 |
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Gene information | Species | Human | Gene symbol | RNASE4 | Gene ID | 6038 |
Gene name | ribonuclease A family member 4 | |
Gene Alias | RAB1 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P34096 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6038 | RNASE4 | LZE4T | Human | Esophagus | ESCC | 2.45e-09 | 2.80e-01 | 0.0811 |
6038 | RNASE4 | LZE5T | Human | Esophagus | ESCC | 5.52e-13 | 7.68e-01 | 0.0514 |
6038 | RNASE4 | LZE24T | Human | Esophagus | ESCC | 4.99e-09 | 2.95e-01 | 0.0596 |
6038 | RNASE4 | P1T-E | Human | Esophagus | ESCC | 2.97e-02 | 1.36e-01 | 0.0875 |
6038 | RNASE4 | P2T-E | Human | Esophagus | ESCC | 1.00e-04 | 1.25e-01 | 0.1177 |
6038 | RNASE4 | P4T-E | Human | Esophagus | ESCC | 2.23e-06 | 1.74e-01 | 0.1323 |
6038 | RNASE4 | P8T-E | Human | Esophagus | ESCC | 6.34e-33 | 6.53e-01 | 0.0889 |
6038 | RNASE4 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 1.99e-01 | 0.1131 |
6038 | RNASE4 | P10T-E | Human | Esophagus | ESCC | 2.39e-09 | 2.19e-01 | 0.116 |
6038 | RNASE4 | P11T-E | Human | Esophagus | ESCC | 2.46e-02 | 1.22e-01 | 0.1426 |
6038 | RNASE4 | P12T-E | Human | Esophagus | ESCC | 1.05e-13 | 4.12e-01 | 0.1122 |
6038 | RNASE4 | P15T-E | Human | Esophagus | ESCC | 1.87e-22 | 4.48e-01 | 0.1149 |
6038 | RNASE4 | P16T-E | Human | Esophagus | ESCC | 7.31e-12 | 1.59e-01 | 0.1153 |
6038 | RNASE4 | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 3.20e-01 | 0.1278 |
6038 | RNASE4 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 2.73e-01 | 0.1662 |
6038 | RNASE4 | P21T-E | Human | Esophagus | ESCC | 6.02e-06 | 1.61e-01 | 0.1617 |
6038 | RNASE4 | P22T-E | Human | Esophagus | ESCC | 1.33e-17 | 3.41e-01 | 0.1236 |
6038 | RNASE4 | P23T-E | Human | Esophagus | ESCC | 1.48e-05 | 2.26e-01 | 0.108 |
6038 | RNASE4 | P26T-E | Human | Esophagus | ESCC | 4.22e-18 | 3.55e-01 | 0.1276 |
6038 | RNASE4 | P28T-E | Human | Esophagus | ESCC | 1.81e-06 | 2.40e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:00063793 | Esophagus | ESCC | mRNA cleavage | 17/8552 | 22/18723 | 2.60e-03 | 1.11e-02 | 17 |
GO:0090501 | Liver | Cirrhotic | RNA phosphodiester bond hydrolysis | 54/4634 | 152/18723 | 1.89e-03 | 1.19e-02 | 54 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:0090502 | Liver | HCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 52/7958 | 82/18723 | 1.06e-04 | 9.08e-04 | 52 |
GO:0006379 | Liver | HCC | mRNA cleavage | 17/7958 | 22/18723 | 9.84e-04 | 5.70e-03 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNASE4 | insertion | In_Frame_Ins | novel | c.313_314insATC | p.Lys105delinsAsnGln | p.K105delinsNQ | P34096 | protein_coding | TCGA-DD-A4NH-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | sorafenib | PD | ||
RNASE4 | SNV | Missense_Mutation | c.56N>A | p.Gly19Glu | p.G19E | P34096 | protein_coding | tolerated(0.13) | probably_damaging(0.959) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RNASE4 | SNV | Missense_Mutation | novel | c.77C>G | p.Ser26Cys | p.S26C | P34096 | protein_coding | deleterious(0.01) | benign(0.159) | TCGA-CV-A45Q-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNASE4 | SNV | Missense_Mutation | rs764066337 | c.269N>C | p.Ile90Thr | p.I90T | P34096 | protein_coding | tolerated(0.06) | benign(0.083) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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