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Gene: RIOK1 |
Gene summary for RIOK1 |
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Gene information | Species | Human | Gene symbol | RIOK1 | Gene ID | 83732 |
Gene name | RIO kinase 1 | |
Gene Alias | AD034 | |
Cytomap | 6p24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BRS2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83732 | RIOK1 | LZE4T | Human | Esophagus | ESCC | 2.39e-18 | 5.40e-01 | 0.0811 |
83732 | RIOK1 | LZE7T | Human | Esophagus | ESCC | 1.73e-05 | 4.31e-01 | 0.0667 |
83732 | RIOK1 | LZE8T | Human | Esophagus | ESCC | 2.48e-06 | 2.28e-01 | 0.067 |
83732 | RIOK1 | LZE22T | Human | Esophagus | ESCC | 1.95e-04 | 4.89e-01 | 0.068 |
83732 | RIOK1 | LZE24T | Human | Esophagus | ESCC | 1.51e-05 | 3.65e-01 | 0.0596 |
83732 | RIOK1 | LZE21T | Human | Esophagus | ESCC | 6.38e-06 | 4.84e-01 | 0.0655 |
83732 | RIOK1 | P1T-E | Human | Esophagus | ESCC | 9.44e-10 | 4.80e-01 | 0.0875 |
83732 | RIOK1 | P2T-E | Human | Esophagus | ESCC | 3.02e-28 | 6.95e-01 | 0.1177 |
83732 | RIOK1 | P4T-E | Human | Esophagus | ESCC | 3.00e-29 | 1.01e+00 | 0.1323 |
83732 | RIOK1 | P5T-E | Human | Esophagus | ESCC | 7.66e-19 | 2.98e-01 | 0.1327 |
83732 | RIOK1 | P8T-E | Human | Esophagus | ESCC | 1.27e-12 | 2.63e-01 | 0.0889 |
83732 | RIOK1 | P9T-E | Human | Esophagus | ESCC | 8.36e-21 | 6.19e-01 | 0.1131 |
83732 | RIOK1 | P10T-E | Human | Esophagus | ESCC | 3.04e-36 | 8.06e-01 | 0.116 |
83732 | RIOK1 | P11T-E | Human | Esophagus | ESCC | 3.27e-19 | 8.81e-01 | 0.1426 |
83732 | RIOK1 | P12T-E | Human | Esophagus | ESCC | 4.34e-19 | 4.96e-01 | 0.1122 |
83732 | RIOK1 | P15T-E | Human | Esophagus | ESCC | 7.41e-17 | 5.10e-01 | 0.1149 |
83732 | RIOK1 | P16T-E | Human | Esophagus | ESCC | 4.45e-33 | 6.99e-01 | 0.1153 |
83732 | RIOK1 | P17T-E | Human | Esophagus | ESCC | 2.52e-12 | 7.25e-01 | 0.1278 |
83732 | RIOK1 | P20T-E | Human | Esophagus | ESCC | 2.80e-39 | 1.02e+00 | 0.1124 |
83732 | RIOK1 | P21T-E | Human | Esophagus | ESCC | 3.12e-26 | 7.15e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:2000234 | Esophagus | ESCC | positive regulation of rRNA processing | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:004227422 | Liver | HCC | ribosomal small subunit biogenesis | 65/7958 | 73/18723 | 1.09e-16 | 9.92e-15 | 65 |
GO:00304901 | Liver | HCC | maturation of SSU-rRNA | 43/7958 | 50/18723 | 2.35e-10 | 8.04e-09 | 43 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIOK1 | SNV | Missense_Mutation | novel | c.191A>G | p.Asp64Gly | p.D64G | Q9BRS2 | protein_coding | tolerated(0.06) | benign(0.047) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RIOK1 | SNV | Missense_Mutation | c.276N>T | p.Gln92His | p.Q92H | Q9BRS2 | protein_coding | deleterious(0.04) | possibly_damaging(0.827) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RIOK1 | SNV | Missense_Mutation | rs749041843 | c.692N>A | p.Arg231His | p.R231H | Q9BRS2 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RIOK1 | SNV | Missense_Mutation | novel | c.411N>C | p.Glu137Asp | p.E137D | Q9BRS2 | protein_coding | tolerated(0.11) | benign(0.006) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RIOK1 | SNV | Missense_Mutation | c.847N>A | p.Asp283Asn | p.D283N | Q9BRS2 | protein_coding | tolerated(0.28) | benign(0.02) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RIOK1 | SNV | Missense_Mutation | rs376101720 | c.1212N>T | p.Glu404Asp | p.E404D | Q9BRS2 | protein_coding | deleterious(0.03) | benign(0.063) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RIOK1 | SNV | Missense_Mutation | rs138314843 | c.691N>T | p.Arg231Cys | p.R231C | Q9BRS2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RIOK1 | insertion | Frame_Shift_Ins | novel | c.1692_1693insA | p.Gly567ArgfsTer5 | p.G567Rfs*5 | Q9BRS2 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RIOK1 | insertion | In_Frame_Ins | rs764932797 | c.189_191dupTGA | p.Asp69dup | p.D69dup | Q9BRS2 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
RIOK1 | insertion | Frame_Shift_Ins | novel | c.1590_1591insA | p.Glu533ArgfsTer20 | p.E533Rfs*20 | Q9BRS2 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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