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Gene: RHPN1 |
Gene summary for RHPN1 |
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Gene information | Species | Human | Gene symbol | RHPN1 | Gene ID | 114822 |
Gene name | rhophilin Rho GTPase binding protein 1 | |
Gene Alias | ODF5 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8TCX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114822 | RHPN1 | HCC1_Meng | Human | Liver | HCC | 9.45e-09 | 3.63e-02 | 0.0246 |
114822 | RHPN1 | HCC2_Meng | Human | Liver | HCC | 4.23e-17 | 1.71e-01 | 0.0107 |
114822 | RHPN1 | S014 | Human | Liver | HCC | 1.92e-08 | 3.26e-01 | 0.2254 |
114822 | RHPN1 | S015 | Human | Liver | HCC | 5.21e-17 | 5.92e-01 | 0.2375 |
114822 | RHPN1 | S016 | Human | Liver | HCC | 8.16e-08 | 2.73e-01 | 0.2243 |
114822 | RHPN1 | S027 | Human | Liver | HCC | 9.66e-20 | 8.41e-01 | 0.2446 |
114822 | RHPN1 | S028 | Human | Liver | HCC | 1.69e-33 | 9.02e-01 | 0.2503 |
114822 | RHPN1 | S029 | Human | Liver | HCC | 2.30e-29 | 8.49e-01 | 0.2581 |
114822 | RHPN1 | male-WTA | Human | Thyroid | PTC | 1.22e-05 | 9.03e-02 | 0.1037 |
114822 | RHPN1 | PTC01 | Human | Thyroid | PTC | 1.80e-19 | 3.01e-01 | 0.1899 |
114822 | RHPN1 | PTC03 | Human | Thyroid | PTC | 2.61e-06 | 3.40e-01 | 0.1784 |
114822 | RHPN1 | PTC04 | Human | Thyroid | PTC | 1.71e-15 | 2.80e-01 | 0.1927 |
114822 | RHPN1 | PTC05 | Human | Thyroid | PTC | 1.32e-28 | 8.59e-01 | 0.2065 |
114822 | RHPN1 | PTC06 | Human | Thyroid | PTC | 6.41e-31 | 6.91e-01 | 0.2057 |
114822 | RHPN1 | PTC07 | Human | Thyroid | PTC | 1.41e-32 | 4.92e-01 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHPN1 | SNV | Missense_Mutation | novel | c.1911N>T | p.Trp637Cys | p.W637C | Q8TCX5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RHPN1 | SNV | Missense_Mutation | novel | c.617N>G | p.Gln206Arg | p.Q206R | Q8TCX5 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
RHPN1 | SNV | Missense_Mutation | c.229N>A | p.Val77Ile | p.V77I | Q8TCX5 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RHPN1 | SNV | Missense_Mutation | c.568N>A | p.Gly190Arg | p.G190R | Q8TCX5 | protein_coding | deleterious(0.02) | benign(0.208) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RHPN1 | SNV | Missense_Mutation | rs149047880 | c.155C>T | p.Thr52Met | p.T52M | Q8TCX5 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
RHPN1 | SNV | Missense_Mutation | c.1879A>T | p.Thr627Ser | p.T627S | Q8TCX5 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
RHPN1 | SNV | Missense_Mutation | c.860N>A | p.Cys287Tyr | p.C287Y | Q8TCX5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DY-A0XA-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | mayo | CR | |
RHPN1 | SNV | Missense_Mutation | rs772768650 | c.1132G>A | p.Glu378Lys | p.E378K | Q8TCX5 | protein_coding | tolerated(0.06) | benign(0.371) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RHPN1 | SNV | Missense_Mutation | rs754928427 | c.922N>T | p.Arg308Cys | p.R308C | Q8TCX5 | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RHPN1 | insertion | Frame_Shift_Ins | novel | c.1960_1961insC | p.Val656SerfsTer93 | p.V656Sfs*93 | Q8TCX5 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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