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Gene: RGS9 |
Gene summary for RGS9 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RGS9 | Gene ID | 8787 |
Gene name | regulator of G protein signaling 9 | |
Gene Alias | PERRS | |
Cytomap | 17q24.1 | |
Gene Type | protein-coding | GO ID | GO:0001975 | UniProtAcc | O75916 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8787 | RGS9 | S015 | Human | Liver | HCC | 5.35e-05 | 1.70e-01 | 0.2375 |
8787 | RGS9 | S027 | Human | Liver | HCC | 1.09e-12 | 9.09e-01 | 0.2446 |
8787 | RGS9 | S028 | Human | Liver | HCC | 1.80e-12 | 4.44e-01 | 0.2503 |
8787 | RGS9 | S029 | Human | Liver | HCC | 1.62e-17 | 7.03e-01 | 0.2581 |
8787 | RGS9 | HTA12-15-2 | Human | Pancreas | PDAC | 5.41e-05 | 5.24e-01 | 0.2315 |
8787 | RGS9 | HTA12-26-1 | Human | Pancreas | PDAC | 1.32e-09 | 5.11e-01 | 0.3728 |
8787 | RGS9 | HTA12-29-1 | Human | Pancreas | PDAC | 2.28e-29 | 6.81e-01 | 0.3722 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:00714782 | Liver | HCC | cellular response to radiation | 104/7958 | 186/18723 | 1.48e-04 | 1.19e-03 | 104 |
GO:00323552 | Liver | HCC | response to estradiol | 81/7958 | 141/18723 | 2.39e-04 | 1.79e-03 | 81 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RGS9 | SNV | Missense_Mutation | c.1790N>A | p.Ala597Asp | p.A597D | O75916 | protein_coding | tolerated_low_confidence(0.07) | probably_damaging(0.997) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RGS9 | SNV | Missense_Mutation | c.1756N>A | p.Leu586Met | p.L586M | O75916 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.889) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RGS9 | SNV | Missense_Mutation | c.1153C>T | p.Arg385Cys | p.R385C | O75916 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RGS9 | SNV | Missense_Mutation | rs759032207 | c.1672N>A | p.Glu558Lys | p.E558K | O75916 | protein_coding | tolerated_low_confidence(0.22) | benign(0.015) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RGS9 | SNV | Missense_Mutation | c.1444N>A | p.Val482Met | p.V482M | O75916 | protein_coding | deleterious(0.04) | probably_damaging(0.962) | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |
RGS9 | SNV | Missense_Mutation | c.343N>A | p.Pro115Thr | p.P115T | O75916 | protein_coding | deleterious(0.05) | benign(0.175) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RGS9 | SNV | Missense_Mutation | c.1982N>T | p.Arg661Leu | p.R661L | O75916 | protein_coding | tolerated_low_confidence(0.06) | benign(0.044) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
RGS9 | SNV | Missense_Mutation | c.1522G>A | p.Ala508Thr | p.A508T | O75916 | protein_coding | tolerated_low_confidence(0.46) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RGS9 | SNV | Missense_Mutation | c.1229N>A | p.Ser410Tyr | p.S410Y | O75916 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RGS9 | SNV | Missense_Mutation | c.1893N>A | p.Asn631Lys | p.N631K | O75916 | protein_coding | deleterious_low_confidence(0.01) | benign(0.214) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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