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Gene: RFK |
Gene summary for RFK |
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Gene information | Species | Human | Gene symbol | RFK | Gene ID | 55312 |
Gene name | riboflavin kinase | |
Gene Alias | RIFK | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B2RDZ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55312 | RFK | HTA11_78_2000001011 | Human | Colorectum | AD | 4.00e-03 | 2.79e-01 | -0.1088 |
55312 | RFK | HTA11_347_2000001011 | Human | Colorectum | AD | 1.55e-07 | 1.89e-01 | -0.1954 |
55312 | RFK | HTA11_866_3004761011 | Human | Colorectum | AD | 5.84e-03 | 1.35e-01 | 0.096 |
55312 | RFK | HTA11_6801_2000001011 | Human | Colorectum | SER | 5.64e-04 | 3.83e-01 | 0.0171 |
55312 | RFK | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.97e-12 | 3.95e-01 | 0.294 |
55312 | RFK | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.78e-03 | 8.28e-01 | 0.3487 |
55312 | RFK | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.16e-04 | 2.18e-01 | 0.281 |
55312 | RFK | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.23e-05 | 3.34e-01 | 0.3859 |
55312 | RFK | LZE4T | Human | Esophagus | ESCC | 5.92e-03 | 2.94e-01 | 0.0811 |
55312 | RFK | LZE5T | Human | Esophagus | ESCC | 4.61e-02 | 2.40e-01 | 0.0514 |
55312 | RFK | LZE24T | Human | Esophagus | ESCC | 1.01e-07 | 2.16e-01 | 0.0596 |
55312 | RFK | LZE21T | Human | Esophagus | ESCC | 9.43e-03 | 2.49e-01 | 0.0655 |
55312 | RFK | P2T-E | Human | Esophagus | ESCC | 6.12e-29 | 4.78e-01 | 0.1177 |
55312 | RFK | P4T-E | Human | Esophagus | ESCC | 1.32e-13 | 3.03e-01 | 0.1323 |
55312 | RFK | P5T-E | Human | Esophagus | ESCC | 7.72e-15 | 2.36e-01 | 0.1327 |
55312 | RFK | P8T-E | Human | Esophagus | ESCC | 6.39e-16 | 3.69e-01 | 0.0889 |
55312 | RFK | P9T-E | Human | Esophagus | ESCC | 4.57e-04 | 1.64e-01 | 0.1131 |
55312 | RFK | P10T-E | Human | Esophagus | ESCC | 4.35e-12 | 2.49e-01 | 0.116 |
55312 | RFK | P11T-E | Human | Esophagus | ESCC | 9.22e-13 | 5.35e-01 | 0.1426 |
55312 | RFK | P12T-E | Human | Esophagus | ESCC | 6.93e-13 | 2.59e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0009260 | Colorectum | AD | ribonucleotide biosynthetic process | 66/3918 | 182/18723 | 1.25e-06 | 4.02e-05 | 66 |
GO:0046390 | Colorectum | AD | ribose phosphate biosynthetic process | 67/3918 | 190/18723 | 3.21e-06 | 9.05e-05 | 67 |
GO:1901293 | Colorectum | AD | nucleoside phosphate biosynthetic process | 80/3918 | 256/18723 | 6.31e-05 | 1.05e-03 | 80 |
GO:0009165 | Colorectum | AD | nucleotide biosynthetic process | 79/3918 | 254/18723 | 8.33e-05 | 1.30e-03 | 79 |
GO:0072593 | Colorectum | AD | reactive oxygen species metabolic process | 73/3918 | 239/18723 | 2.79e-04 | 3.42e-03 | 73 |
GO:0051353 | Colorectum | AD | positive regulation of oxidoreductase activity | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
GO:00092591 | Colorectum | SER | ribonucleotide metabolic process | 104/2897 | 385/18723 | 3.27e-09 | 3.04e-07 | 104 |
GO:00196931 | Colorectum | SER | ribose phosphate metabolic process | 105/2897 | 396/18723 | 8.15e-09 | 7.14e-07 | 105 |
GO:00091171 | Colorectum | SER | nucleotide metabolic process | 122/2897 | 489/18723 | 2.50e-08 | 1.76e-06 | 122 |
GO:00067531 | Colorectum | SER | nucleoside phosphate metabolic process | 122/2897 | 497/18723 | 6.64e-08 | 4.33e-06 | 122 |
GO:00725931 | Colorectum | SER | reactive oxygen species metabolic process | 61/2897 | 239/18723 | 3.63e-05 | 9.39e-04 | 61 |
GO:00092601 | Colorectum | SER | ribonucleotide biosynthetic process | 49/2897 | 182/18723 | 4.85e-05 | 1.19e-03 | 49 |
GO:00463901 | Colorectum | SER | ribose phosphate biosynthetic process | 50/2897 | 190/18723 | 7.70e-05 | 1.72e-03 | 50 |
GO:00091651 | Colorectum | SER | nucleotide biosynthetic process | 58/2897 | 254/18723 | 1.21e-03 | 1.38e-02 | 58 |
GO:19012931 | Colorectum | SER | nucleoside phosphate biosynthetic process | 58/2897 | 256/18723 | 1.47e-03 | 1.59e-02 | 58 |
GO:0051341 | Colorectum | SER | regulation of oxidoreductase activity | 27/2897 | 107/18723 | 5.86e-03 | 4.29e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RFK | insertion | Frame_Shift_Ins | novel | c.379_380insC | p.Lys127ThrfsTer22 | p.K127Tfs*22 | Q969G6 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
RFK | insertion | Nonsense_Mutation | novel | c.378_379insGAACAGTAATAAAC | p.Lys127GlufsTer3 | p.K127Efs*3 | Q969G6 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
RFK | SNV | Missense_Mutation | c.365A>T | p.Asp122Val | p.D122V | Q969G6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EJ-5505-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
RFK | SNV | Missense_Mutation | novel | c.7C>T | p.His3Tyr | p.H3Y | Q969G6 | protein_coding | tolerated(0.63) | benign(0) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
RFK | SNV | Missense_Mutation | c.368N>C | p.Ile123Thr | p.I123T | Q969G6 | protein_coding | deleterious(0.04) | possibly_damaging(0.902) | TCGA-D7-6815-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55312 | RFK | KINASE, ENZYME | escitalopram | ESCITALOPRAM | ||
55312 | RFK | KINASE, ENZYME | citalopram | CITALOPRAM |
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