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Gene: RFC2 |
Gene summary for RFC2 |
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Gene information | Species | Human | Gene symbol | RFC2 | Gene ID | 5982 |
Gene name | replication factor C subunit 2 | |
Gene Alias | RFC40 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P35250 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5982 | RFC2 | LZE2T | Human | Esophagus | ESCC | 5.50e-05 | 5.11e-01 | 0.082 |
5982 | RFC2 | LZE4T | Human | Esophagus | ESCC | 1.59e-05 | 1.62e-01 | 0.0811 |
5982 | RFC2 | LZE7T | Human | Esophagus | ESCC | 1.54e-12 | 7.59e-01 | 0.0667 |
5982 | RFC2 | LZE8T | Human | Esophagus | ESCC | 5.80e-06 | 2.45e-01 | 0.067 |
5982 | RFC2 | LZE20T | Human | Esophagus | ESCC | 4.15e-03 | 6.83e-02 | 0.0662 |
5982 | RFC2 | LZE22T | Human | Esophagus | ESCC | 9.84e-11 | 6.23e-01 | 0.068 |
5982 | RFC2 | LZE24T | Human | Esophagus | ESCC | 1.11e-13 | 2.97e-01 | 0.0596 |
5982 | RFC2 | LZE21T | Human | Esophagus | ESCC | 1.28e-04 | 3.36e-01 | 0.0655 |
5982 | RFC2 | LZE6T | Human | Esophagus | ESCC | 3.31e-09 | 4.27e-01 | 0.0845 |
5982 | RFC2 | P1T-E | Human | Esophagus | ESCC | 1.50e-10 | 6.99e-01 | 0.0875 |
5982 | RFC2 | P2T-E | Human | Esophagus | ESCC | 1.86e-26 | 7.01e-01 | 0.1177 |
5982 | RFC2 | P4T-E | Human | Esophagus | ESCC | 7.45e-32 | 7.52e-01 | 0.1323 |
5982 | RFC2 | P5T-E | Human | Esophagus | ESCC | 2.06e-23 | 6.32e-01 | 0.1327 |
5982 | RFC2 | P8T-E | Human | Esophagus | ESCC | 3.32e-16 | 4.13e-01 | 0.0889 |
5982 | RFC2 | P9T-E | Human | Esophagus | ESCC | 1.37e-14 | 3.57e-01 | 0.1131 |
5982 | RFC2 | P10T-E | Human | Esophagus | ESCC | 1.48e-30 | 6.48e-01 | 0.116 |
5982 | RFC2 | P11T-E | Human | Esophagus | ESCC | 5.67e-12 | 4.64e-01 | 0.1426 |
5982 | RFC2 | P12T-E | Human | Esophagus | ESCC | 1.63e-29 | 5.93e-01 | 0.1122 |
5982 | RFC2 | P15T-E | Human | Esophagus | ESCC | 2.73e-25 | 6.97e-01 | 0.1149 |
5982 | RFC2 | P16T-E | Human | Esophagus | ESCC | 4.03e-33 | 8.96e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:005105417 | Esophagus | ESCC | positive regulation of DNA metabolic process | 139/8552 | 201/18723 | 1.20e-11 | 4.33e-10 | 139 |
GO:200057319 | Esophagus | ESCC | positive regulation of DNA biosynthetic process | 56/8552 | 66/18723 | 4.51e-11 | 1.45e-09 | 56 |
GO:2000278110 | Esophagus | ESCC | regulation of DNA biosynthetic process | 81/8552 | 106/18723 | 9.81e-11 | 2.96e-09 | 81 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:003239214 | Esophagus | ESCC | DNA geometric change | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:003250813 | Esophagus | ESCC | DNA duplex unwinding | 58/8552 | 84/18723 | 1.23e-05 | 1.14e-04 | 58 |
GO:0090329 | Esophagus | ESCC | regulation of DNA-dependent DNA replication | 30/8552 | 46/18723 | 5.91e-03 | 2.18e-02 | 30 |
GO:005105221 | Liver | HCC | regulation of DNA metabolic process | 198/7958 | 359/18723 | 7.62e-07 | 1.17e-05 | 198 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:005105411 | Liver | HCC | positive regulation of DNA metabolic process | 113/7958 | 201/18723 | 5.76e-05 | 5.33e-04 | 113 |
GO:200027812 | Liver | HCC | regulation of DNA biosynthetic process | 64/7958 | 106/18723 | 1.53e-04 | 1.23e-03 | 64 |
GO:00718975 | Liver | HCC | DNA biosynthetic process | 99/7958 | 180/18723 | 4.66e-04 | 3.08e-03 | 99 |
GO:003239211 | Liver | HCC | DNA geometric change | 54/7958 | 90/18723 | 6.04e-04 | 3.79e-03 | 54 |
GO:200057312 | Liver | HCC | positive regulation of DNA biosynthetic process | 41/7958 | 66/18723 | 1.02e-03 | 5.86e-03 | 41 |
GO:00325081 | Liver | HCC | DNA duplex unwinding | 49/7958 | 84/18723 | 2.46e-03 | 1.19e-02 | 49 |
GO:00062751 | Liver | HCC | regulation of DNA replication | 60/7958 | 107/18723 | 3.15e-03 | 1.46e-02 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0342022 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa034104 | Esophagus | ESCC | Base excision repair | 38/4205 | 44/8465 | 3.59e-07 | 2.62e-06 | 1.34e-06 | 38 |
hsa030304 | Esophagus | ESCC | DNA replication | 32/4205 | 36/8465 | 7.71e-07 | 5.06e-06 | 2.59e-06 | 32 |
hsa034304 | Esophagus | ESCC | Mismatch repair | 21/4205 | 23/8465 | 2.85e-05 | 1.35e-04 | 6.90e-05 | 21 |
hsa0342032 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0341011 | Esophagus | ESCC | Base excision repair | 38/4205 | 44/8465 | 3.59e-07 | 2.62e-06 | 1.34e-06 | 38 |
hsa0303011 | Esophagus | ESCC | DNA replication | 32/4205 | 36/8465 | 7.71e-07 | 5.06e-06 | 2.59e-06 | 32 |
hsa0343011 | Esophagus | ESCC | Mismatch repair | 21/4205 | 23/8465 | 2.85e-05 | 1.35e-04 | 6.90e-05 | 21 |
hsa034202 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa034203 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa034204 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa03030 | Oral cavity | OSCC | DNA replication | 31/3704 | 36/8465 | 1.70e-07 | 1.19e-06 | 6.03e-07 | 31 |
hsa03410 | Oral cavity | OSCC | Base excision repair | 32/3704 | 44/8465 | 9.11e-05 | 3.25e-04 | 1.65e-04 | 32 |
hsa03430 | Oral cavity | OSCC | Mismatch repair | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
hsa0342011 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa030301 | Oral cavity | OSCC | DNA replication | 31/3704 | 36/8465 | 1.70e-07 | 1.19e-06 | 6.03e-07 | 31 |
hsa034101 | Oral cavity | OSCC | Base excision repair | 32/3704 | 44/8465 | 9.11e-05 | 3.25e-04 | 1.65e-04 | 32 |
hsa034301 | Oral cavity | OSCC | Mismatch repair | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
hsa0342021 | Oral cavity | LP | Nucleotide excision repair | 37/2418 | 63/8465 | 5.14e-07 | 6.33e-06 | 4.08e-06 | 37 |
hsa030302 | Oral cavity | LP | DNA replication | 23/2418 | 36/8465 | 1.08e-05 | 7.79e-05 | 5.02e-05 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RFC2 | SNV | Missense_Mutation | rs781977542 | c.829N>A | p.Glu277Lys | p.E277K | P35250 | protein_coding | tolerated(0.34) | benign(0.021) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
RFC2 | SNV | Missense_Mutation | novel | c.521C>T | p.Ser174Leu | p.S174L | P35250 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RFC2 | SNV | Missense_Mutation | c.502N>A | p.Ala168Thr | p.A168T | P35250 | protein_coding | deleterious(0) | possibly_damaging(0.76) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
RFC2 | SNV | Missense_Mutation | rs782546413 | c.848N>T | p.Ala283Val | p.A283V | P35250 | protein_coding | tolerated(0.36) | benign(0.038) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RFC2 | SNV | Missense_Mutation | c.464G>T | p.Arg155Met | p.R155M | P35250 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RFC2 | SNV | Missense_Mutation | rs781895699 | c.317N>G | p.Asn106Ser | p.N106S | P35250 | protein_coding | tolerated(0.05) | possibly_damaging(0.451) | TCGA-BG-A0MU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD |
RFC2 | SNV | Missense_Mutation | c.227N>C | p.Gly76Ala | p.G76A | P35250 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
RFC2 | SNV | Missense_Mutation | novel | c.566N>A | p.Arg189Gln | p.R189Q | P35250 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A1O7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RFC2 | SNV | Missense_Mutation | c.169N>A | p.Val57Met | p.V57M | P35250 | protein_coding | deleterious(0.04) | probably_damaging(0.941) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
RFC2 | SNV | Missense_Mutation | rs148234405 | c.356N>C | p.Lys119Thr | p.K119T | P35250 | protein_coding | deleterious(0.01) | possibly_damaging(0.788) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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