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Gene: RETSAT |
Gene summary for RETSAT |
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Gene information | Species | Human | Gene symbol | RETSAT | Gene ID | 54884 |
Gene name | retinol saturase | |
Gene Alias | RETSAT | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | Q6NUM9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54884 | RETSAT | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.50e-09 | 5.29e-01 | -0.1808 |
54884 | RETSAT | HTA11_78_2000001011 | Human | Colorectum | AD | 7.57e-09 | 5.37e-01 | -0.1088 |
54884 | RETSAT | HTA11_347_2000001011 | Human | Colorectum | AD | 5.03e-41 | 1.05e+00 | -0.1954 |
54884 | RETSAT | HTA11_2112_2000001011 | Human | Colorectum | SER | 9.92e-08 | 9.98e-01 | -0.2196 |
54884 | RETSAT | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.30e-03 | 4.49e-01 | -0.1207 |
54884 | RETSAT | HTA11_83_2000001011 | Human | Colorectum | SER | 1.47e-11 | 7.76e-01 | -0.1526 |
54884 | RETSAT | HTA11_696_2000001011 | Human | Colorectum | AD | 8.32e-15 | 6.55e-01 | -0.1464 |
54884 | RETSAT | HTA11_866_2000001011 | Human | Colorectum | AD | 6.58e-07 | 3.69e-01 | -0.1001 |
54884 | RETSAT | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.81e-12 | 6.26e-01 | -0.059 |
54884 | RETSAT | HTA11_2992_2000001011 | Human | Colorectum | SER | 8.11e-03 | 6.93e-01 | -0.1706 |
54884 | RETSAT | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.80e-02 | 6.88e-01 | -0.1462 |
54884 | RETSAT | HTA11_546_2000001011 | Human | Colorectum | AD | 1.21e-02 | 2.53e-01 | -0.0842 |
54884 | RETSAT | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.33e-05 | 3.66e-01 | 0.3859 |
54884 | RETSAT | A015-C-203 | Human | Colorectum | FAP | 3.19e-05 | -2.31e-01 | -0.1294 |
54884 | RETSAT | A002-C-205 | Human | Colorectum | FAP | 3.59e-03 | -2.13e-01 | -0.1236 |
54884 | RETSAT | A015-C-104 | Human | Colorectum | FAP | 1.25e-04 | -2.04e-01 | -0.1899 |
54884 | RETSAT | A001-C-014 | Human | Colorectum | FAP | 2.01e-03 | -1.82e-01 | 0.0135 |
54884 | RETSAT | A002-C-016 | Human | Colorectum | FAP | 9.46e-03 | -1.74e-01 | 0.0521 |
54884 | RETSAT | A002-C-116 | Human | Colorectum | FAP | 4.01e-05 | -2.06e-01 | -0.0452 |
54884 | RETSAT | A018-E-020 | Human | Colorectum | FAP | 3.56e-03 | -2.36e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0034308 | Colorectum | AD | primary alcohol metabolic process | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:00060661 | Colorectum | SER | alcohol metabolic process | 79/2897 | 353/18723 | 3.50e-04 | 5.50e-03 | 79 |
GO:00343081 | Colorectum | SER | primary alcohol metabolic process | 26/2897 | 102/18723 | 5.87e-03 | 4.29e-02 | 26 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:00060663 | Colorectum | FAP | alcohol metabolic process | 69/2622 | 353/18723 | 2.29e-03 | 1.85e-02 | 69 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:000606621 | Liver | HCC | alcohol metabolic process | 208/7958 | 353/18723 | 2.80e-10 | 9.50e-09 | 208 |
GO:000672011 | Liver | HCC | isoprenoid metabolic process | 65/7958 | 116/18723 | 2.23e-03 | 1.11e-02 | 65 |
GO:003430812 | Liver | HCC | primary alcohol metabolic process | 55/7958 | 102/18723 | 1.30e-02 | 4.67e-02 | 55 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:00067203 | Oral cavity | OSCC | isoprenoid metabolic process | 59/7305 | 116/18723 | 6.18e-03 | 2.33e-02 | 59 |
GO:000606613 | Oral cavity | LP | alcohol metabolic process | 111/4623 | 353/18723 | 2.24e-03 | 1.62e-02 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RETSAT | SNV | Missense_Mutation | novel | c.1814N>T | p.Ala605Val | p.A605V | Q6NUM9 | protein_coding | tolerated(0.07) | benign(0.081) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
RETSAT | SNV | Missense_Mutation | rs752059565 | c.1439G>A | p.Gly480Glu | p.G480E | Q6NUM9 | protein_coding | tolerated(0.49) | benign(0.358) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RETSAT | SNV | Missense_Mutation | c.232G>C | p.Gly78Arg | p.G78R | Q6NUM9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RETSAT | SNV | Missense_Mutation | c.1784N>C | p.Asp595Ala | p.D595A | Q6NUM9 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RETSAT | SNV | Missense_Mutation | novel | c.401N>C | p.Phe134Ser | p.F134S | Q6NUM9 | protein_coding | deleterious(0.02) | benign(0.407) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RETSAT | SNV | Missense_Mutation | novel | c.338N>A | p.Gly113Asp | p.G113D | Q6NUM9 | protein_coding | deleterious(0.02) | probably_damaging(0.923) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RETSAT | SNV | Missense_Mutation | c.1461N>T | p.Glu487Asp | p.E487D | Q6NUM9 | protein_coding | tolerated(0.12) | benign(0.042) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RETSAT | SNV | Missense_Mutation | rs867466240 | c.908C>A | p.Thr303Asn | p.T303N | Q6NUM9 | protein_coding | deleterious(0.05) | benign(0.162) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RETSAT | SNV | Missense_Mutation | c.308N>T | p.Gly103Val | p.G103V | Q6NUM9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RETSAT | SNV | Missense_Mutation | novel | c.1067N>G | p.Leu356Arg | p.L356R | Q6NUM9 | protein_coding | deleterious(0) | benign(0.438) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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