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Gene: RCCD1 |
Gene summary for RCCD1 |
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Gene information | Species | Human | Gene symbol | RCCD1 | Gene ID | 91433 |
Gene name | RCC1 domain containing 1 | |
Gene Alias | RCCD1 | |
Cytomap | 15q26.1 | |
Gene Type | protein-coding | GO ID | GO:0006325 | UniProtAcc | A0A024RC72 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91433 | RCCD1 | LZE4T | Human | Esophagus | ESCC | 1.21e-02 | 1.50e-01 | 0.0811 |
91433 | RCCD1 | LZE22T | Human | Esophagus | ESCC | 1.07e-02 | 2.00e-01 | 0.068 |
91433 | RCCD1 | LZE24T | Human | Esophagus | ESCC | 1.15e-04 | 1.42e-01 | 0.0596 |
91433 | RCCD1 | P1T-E | Human | Esophagus | ESCC | 1.32e-03 | 2.73e-01 | 0.0875 |
91433 | RCCD1 | P2T-E | Human | Esophagus | ESCC | 3.96e-14 | 3.01e-01 | 0.1177 |
91433 | RCCD1 | P4T-E | Human | Esophagus | ESCC | 7.67e-14 | 3.53e-01 | 0.1323 |
91433 | RCCD1 | P5T-E | Human | Esophagus | ESCC | 5.94e-11 | 2.42e-01 | 0.1327 |
91433 | RCCD1 | P8T-E | Human | Esophagus | ESCC | 4.09e-13 | 2.29e-01 | 0.0889 |
91433 | RCCD1 | P9T-E | Human | Esophagus | ESCC | 1.98e-07 | 1.93e-01 | 0.1131 |
91433 | RCCD1 | P10T-E | Human | Esophagus | ESCC | 1.72e-20 | 3.78e-01 | 0.116 |
91433 | RCCD1 | P11T-E | Human | Esophagus | ESCC | 2.65e-06 | 2.15e-01 | 0.1426 |
91433 | RCCD1 | P12T-E | Human | Esophagus | ESCC | 4.16e-12 | 2.13e-01 | 0.1122 |
91433 | RCCD1 | P15T-E | Human | Esophagus | ESCC | 2.74e-14 | 3.19e-01 | 0.1149 |
91433 | RCCD1 | P16T-E | Human | Esophagus | ESCC | 9.08e-12 | 3.12e-01 | 0.1153 |
91433 | RCCD1 | P20T-E | Human | Esophagus | ESCC | 2.23e-11 | 2.34e-01 | 0.1124 |
91433 | RCCD1 | P21T-E | Human | Esophagus | ESCC | 2.67e-03 | 1.22e-01 | 0.1617 |
91433 | RCCD1 | P22T-E | Human | Esophagus | ESCC | 8.83e-06 | 1.96e-01 | 0.1236 |
91433 | RCCD1 | P23T-E | Human | Esophagus | ESCC | 2.10e-14 | 3.47e-01 | 0.108 |
91433 | RCCD1 | P24T-E | Human | Esophagus | ESCC | 9.94e-15 | 2.63e-01 | 0.1287 |
91433 | RCCD1 | P26T-E | Human | Esophagus | ESCC | 5.11e-03 | 1.50e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCCD1 | SNV | Missense_Mutation | novel | c.667N>C | p.Val223Leu | p.V223L | A6NED2 | protein_coding | tolerated(0.09) | benign(0.136) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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