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Gene: RBM43 |
Gene summary for RBM43 |
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Gene information | Species | Human | Gene symbol | RBM43 | Gene ID | 375287 |
Gene name | RNA binding motif protein 43 | |
Gene Alias | C2orf38 | |
Cytomap | 2q23.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6ZSC3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375287 | RBM43 | HCC1_Meng | Human | Liver | HCC | 9.57e-26 | 4.05e-02 | 0.0246 |
375287 | RBM43 | HCC2_Meng | Human | Liver | HCC | 1.03e-08 | 1.01e-01 | 0.0107 |
375287 | RBM43 | cirrhotic2 | Human | Liver | Cirrhotic | 1.51e-02 | 1.56e-01 | 0.0201 |
375287 | RBM43 | cirrhotic3 | Human | Liver | Cirrhotic | 9.43e-03 | 1.40e-01 | 0.0215 |
375287 | RBM43 | HCC1 | Human | Liver | HCC | 2.24e-15 | 2.68e+00 | 0.5336 |
375287 | RBM43 | HCC2 | Human | Liver | HCC | 6.27e-23 | 1.75e+00 | 0.5341 |
375287 | RBM43 | HCC5 | Human | Liver | HCC | 9.26e-13 | 1.46e+00 | 0.4932 |
375287 | RBM43 | S027 | Human | Liver | HCC | 2.89e-03 | 3.53e-01 | 0.2446 |
375287 | RBM43 | S028 | Human | Liver | HCC | 6.32e-09 | 3.62e-01 | 0.2503 |
375287 | RBM43 | S029 | Human | Liver | HCC | 3.14e-05 | 3.21e-01 | 0.2581 |
375287 | RBM43 | male-WTA | Human | Thyroid | PTC | 1.86e-14 | 1.21e-01 | 0.1037 |
375287 | RBM43 | PTC01 | Human | Thyroid | PTC | 1.59e-06 | 1.54e-01 | 0.1899 |
375287 | RBM43 | PTC05 | Human | Thyroid | PTC | 3.79e-20 | 6.88e-01 | 0.2065 |
375287 | RBM43 | PTC06 | Human | Thyroid | PTC | 8.04e-16 | 5.11e-01 | 0.2057 |
375287 | RBM43 | PTC07 | Human | Thyroid | PTC | 1.78e-22 | 4.70e-01 | 0.2044 |
375287 | RBM43 | ATC12 | Human | Thyroid | ATC | 2.27e-06 | 2.17e-01 | 0.34 |
375287 | RBM43 | ATC13 | Human | Thyroid | ATC | 2.54e-11 | 2.31e-01 | 0.34 |
375287 | RBM43 | ATC4 | Human | Thyroid | ATC | 8.55e-10 | 2.85e-01 | 0.34 |
375287 | RBM43 | ATC5 | Human | Thyroid | ATC | 1.49e-12 | 2.53e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM43 | SNV | Missense_Mutation | c.938G>A | p.Cys313Tyr | p.C313Y | Q6ZSC3 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RBM43 | insertion | Frame_Shift_Ins | rs746242773 | c.213_214insA | p.Val72SerfsTer18 | p.V72Sfs*18 | Q6ZSC3 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RBM43 | SNV | Missense_Mutation | novel | c.32N>T | p.Lys11Ile | p.K11I | Q6ZSC3 | protein_coding | deleterious(0.03) | possibly_damaging(0.592) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM43 | SNV | Missense_Mutation | novel | c.142N>A | p.Gly48Arg | p.G48R | Q6ZSC3 | protein_coding | deleterious(0.05) | possibly_damaging(0.608) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RBM43 | SNV | Missense_Mutation | novel | c.437C>T | p.Pro146Leu | p.P146L | Q6ZSC3 | protein_coding | tolerated(0.17) | benign(0.173) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBM43 | SNV | Missense_Mutation | novel | c.971N>C | p.Leu324Pro | p.L324P | Q6ZSC3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
RBM43 | SNV | Missense_Mutation | rs374433455 | c.953N>T | p.Ser318Leu | p.S318L | Q6ZSC3 | protein_coding | tolerated(0.69) | benign(0.007) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBM43 | SNV | Missense_Mutation | novel | c.1007G>A | p.Gly336Glu | p.G336E | Q6ZSC3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM43 | SNV | Missense_Mutation | c.593N>T | p.Arg198Ile | p.R198I | Q6ZSC3 | protein_coding | deleterious(0.01) | probably_damaging(0.914) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
RBM43 | SNV | Missense_Mutation | novel | c.949N>C | p.Ser317Arg | p.S317R | Q6ZSC3 | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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