![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RBBP9 |
Gene summary for RBBP9 |
![]() |
Gene information | Species | Human | Gene symbol | RBBP9 | Gene ID | 10741 |
Gene name | RB binding protein 9, serine hydrolase | |
Gene Alias | BOG | |
Cytomap | 20p11.23 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O75884 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10741 | RBBP9 | LZE4T | Human | Esophagus | ESCC | 2.59e-04 | 2.40e-01 | 0.0811 |
10741 | RBBP9 | LZE24T | Human | Esophagus | ESCC | 2.30e-07 | 1.55e-01 | 0.0596 |
10741 | RBBP9 | LZE6T | Human | Esophagus | ESCC | 1.60e-02 | 1.25e-01 | 0.0845 |
10741 | RBBP9 | P2T-E | Human | Esophagus | ESCC | 2.32e-09 | 2.49e-01 | 0.1177 |
10741 | RBBP9 | P4T-E | Human | Esophagus | ESCC | 4.14e-07 | 1.20e-01 | 0.1323 |
10741 | RBBP9 | P5T-E | Human | Esophagus | ESCC | 2.35e-03 | 2.60e-02 | 0.1327 |
10741 | RBBP9 | P8T-E | Human | Esophagus | ESCC | 4.12e-07 | 9.17e-02 | 0.0889 |
10741 | RBBP9 | P9T-E | Human | Esophagus | ESCC | 1.05e-03 | 8.47e-02 | 0.1131 |
10741 | RBBP9 | P10T-E | Human | Esophagus | ESCC | 1.09e-06 | 1.85e-01 | 0.116 |
10741 | RBBP9 | P11T-E | Human | Esophagus | ESCC | 3.07e-04 | 2.07e-01 | 0.1426 |
10741 | RBBP9 | P12T-E | Human | Esophagus | ESCC | 5.55e-07 | 1.87e-01 | 0.1122 |
10741 | RBBP9 | P16T-E | Human | Esophagus | ESCC | 2.26e-13 | 1.97e-01 | 0.1153 |
10741 | RBBP9 | P20T-E | Human | Esophagus | ESCC | 1.08e-04 | 1.29e-01 | 0.1124 |
10741 | RBBP9 | P21T-E | Human | Esophagus | ESCC | 1.65e-16 | 3.37e-01 | 0.1617 |
10741 | RBBP9 | P22T-E | Human | Esophagus | ESCC | 7.34e-08 | 6.35e-02 | 0.1236 |
10741 | RBBP9 | P23T-E | Human | Esophagus | ESCC | 6.96e-07 | 2.12e-01 | 0.108 |
10741 | RBBP9 | P24T-E | Human | Esophagus | ESCC | 3.51e-04 | 1.19e-01 | 0.1287 |
10741 | RBBP9 | P26T-E | Human | Esophagus | ESCC | 7.64e-12 | 2.53e-01 | 0.1276 |
10741 | RBBP9 | P27T-E | Human | Esophagus | ESCC | 1.98e-09 | 1.54e-01 | 0.1055 |
10741 | RBBP9 | P28T-E | Human | Esophagus | ESCC | 1.32e-13 | 8.99e-02 | 0.1149 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBBP9 | SNV | Missense_Mutation | c.103N>G | p.Pro35Ala | p.P35A | O75884 | protein_coding | tolerated(0.58) | benign(0.034) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RBBP9 | SNV | Missense_Mutation | novel | c.476N>C | p.Lys159Thr | p.K159T | O75884 | protein_coding | tolerated(0.36) | benign(0.034) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RBBP9 | SNV | Missense_Mutation | novel | c.111C>A | p.Phe37Leu | p.F37L | O75884 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBBP9 | SNV | Missense_Mutation | c.69N>T | p.Trp23Cys | p.W23C | O75884 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RBBP9 | deletion | Frame_Shift_Del | novel | c.351delN | p.Trp118GlyfsTer57 | p.W118Gfs*57 | O75884 | protein_coding | TCGA-MP-A4T4-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RBBP9 | SNV | Missense_Mutation | novel | c.14N>A | p.Ser5Asn | p.S5N | O75884 | protein_coding | tolerated(0.52) | benign(0) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10741 | RBBP9 | ENZYME, DRUGGABLE GENOME | inhibitor | 252166808 |
Page: 1 |