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Gene: RBBP8 |
Gene summary for RBBP8 |
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Gene information | Species | Human | Gene symbol | RBBP8 | Gene ID | 5932 |
Gene name | RB binding protein 8, endonuclease | |
Gene Alias | COM1 | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024RC34 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5932 | RBBP8 | LZE4T | Human | Esophagus | ESCC | 2.02e-06 | 5.21e-01 | 0.0811 |
5932 | RBBP8 | LZE7T | Human | Esophagus | ESCC | 5.64e-07 | 8.30e-01 | 0.0667 |
5932 | RBBP8 | LZE8T | Human | Esophagus | ESCC | 3.23e-10 | 3.99e-01 | 0.067 |
5932 | RBBP8 | LZE20T | Human | Esophagus | ESCC | 1.06e-06 | 2.64e-02 | 0.0662 |
5932 | RBBP8 | LZE24T | Human | Esophagus | ESCC | 6.48e-05 | 2.13e-01 | 0.0596 |
5932 | RBBP8 | LZE6T | Human | Esophagus | ESCC | 2.55e-05 | 1.21e-01 | 0.0845 |
5932 | RBBP8 | P1T-E | Human | Esophagus | ESCC | 5.00e-03 | 6.90e-01 | 0.0875 |
5932 | RBBP8 | P2T-E | Human | Esophagus | ESCC | 2.62e-70 | 1.40e+00 | 0.1177 |
5932 | RBBP8 | P4T-E | Human | Esophagus | ESCC | 5.73e-26 | 9.59e-01 | 0.1323 |
5932 | RBBP8 | P5T-E | Human | Esophagus | ESCC | 4.13e-06 | 2.30e-01 | 0.1327 |
5932 | RBBP8 | P8T-E | Human | Esophagus | ESCC | 9.89e-17 | 4.60e-01 | 0.0889 |
5932 | RBBP8 | P9T-E | Human | Esophagus | ESCC | 4.71e-18 | 5.92e-01 | 0.1131 |
5932 | RBBP8 | P10T-E | Human | Esophagus | ESCC | 3.71e-41 | 7.27e-01 | 0.116 |
5932 | RBBP8 | P11T-E | Human | Esophagus | ESCC | 1.39e-09 | 1.06e+00 | 0.1426 |
5932 | RBBP8 | P12T-E | Human | Esophagus | ESCC | 6.65e-39 | 7.80e-01 | 0.1122 |
5932 | RBBP8 | P15T-E | Human | Esophagus | ESCC | 3.81e-29 | 7.91e-01 | 0.1149 |
5932 | RBBP8 | P16T-E | Human | Esophagus | ESCC | 1.89e-30 | 6.71e-01 | 0.1153 |
5932 | RBBP8 | P17T-E | Human | Esophagus | ESCC | 1.64e-16 | 8.49e-01 | 0.1278 |
5932 | RBBP8 | P20T-E | Human | Esophagus | ESCC | 2.00e-28 | 7.57e-01 | 0.1124 |
5932 | RBBP8 | P21T-E | Human | Esophagus | ESCC | 2.86e-59 | 1.34e+00 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:000008214 | Esophagus | ESCC | G1/S transition of mitotic cell cycle | 134/8552 | 214/18723 | 4.04e-07 | 5.55e-06 | 134 |
GO:004484314 | Esophagus | ESCC | cell cycle G1/S phase transition | 148/8552 | 241/18723 | 5.68e-07 | 7.48e-06 | 148 |
GO:000182412 | Esophagus | ESCC | blastocyst development | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00007241 | Esophagus | ESCC | double-strand break repair via homologous recombination | 79/8552 | 138/18723 | 4.05e-03 | 1.62e-02 | 79 |
GO:00007251 | Esophagus | ESCC | recombinational repair | 80/8552 | 140/18723 | 4.10e-03 | 1.63e-02 | 80 |
GO:0044772 | Liver | NAFLD | mitotic cell cycle phase transition | 67/1882 | 424/18723 | 1.25e-04 | 2.39e-03 | 67 |
GO:0044843 | Liver | NAFLD | cell cycle G1/S phase transition | 43/1882 | 241/18723 | 1.40e-04 | 2.63e-03 | 43 |
GO:0000082 | Liver | NAFLD | G1/S transition of mitotic cell cycle | 39/1882 | 214/18723 | 1.78e-04 | 3.14e-03 | 39 |
GO:00323553 | Liver | NAFLD | response to estradiol | 25/1882 | 141/18723 | 3.51e-03 | 3.01e-02 | 25 |
GO:00017015 | Liver | Cirrhotic | in utero embryonic development | 134/4634 | 367/18723 | 2.78e-07 | 6.86e-06 | 134 |
GO:00447721 | Liver | Cirrhotic | mitotic cell cycle phase transition | 139/4634 | 424/18723 | 1.02e-04 | 1.06e-03 | 139 |
GO:00323551 | Liver | Cirrhotic | response to estradiol | 51/4634 | 141/18723 | 1.60e-03 | 1.04e-02 | 51 |
GO:00000821 | Liver | Cirrhotic | G1/S transition of mitotic cell cycle | 72/4634 | 214/18723 | 2.07e-03 | 1.28e-02 | 72 |
GO:00448431 | Liver | Cirrhotic | cell cycle G1/S phase transition | 77/4634 | 241/18723 | 6.68e-03 | 3.30e-02 | 77 |
GO:00447722 | Liver | HCC | mitotic cell cycle phase transition | 240/7958 | 424/18723 | 2.47e-09 | 6.84e-08 | 240 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBBP8 | SNV | Missense_Mutation | novel | c.1357G>C | p.Glu453Gln | p.E453Q | Q99708 | protein_coding | deleterious(0.01) | possibly_damaging(0.642) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RBBP8 | SNV | Missense_Mutation | c.634N>T | p.His212Tyr | p.H212Y | Q99708 | protein_coding | tolerated(0.24) | benign(0.243) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RBBP8 | SNV | Missense_Mutation | novel | c.1363N>A | p.Glu455Lys | p.E455K | Q99708 | protein_coding | tolerated(0.08) | benign(0.23) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RBBP8 | SNV | Missense_Mutation | c.799N>A | p.Glu267Lys | p.E267K | Q99708 | protein_coding | deleterious(0.04) | benign(0.322) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RBBP8 | SNV | Missense_Mutation | c.557N>G | p.Tyr186Cys | p.Y186C | Q99708 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RBBP8 | SNV | Missense_Mutation | novel | c.2277N>T | p.Lys759Asn | p.K759N | Q99708 | protein_coding | tolerated(0.07) | benign(0.444) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RBBP8 | SNV | Missense_Mutation | rs760773711 | c.2641N>T | p.Arg881Cys | p.R881C | Q99708 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBBP8 | SNV | Missense_Mutation | c.1705N>A | p.Pro569Thr | p.P569T | Q99708 | protein_coding | deleterious(0.01) | possibly_damaging(0.482) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RBBP8 | SNV | Missense_Mutation | novel | c.2612N>G | p.Asp871Gly | p.D871G | Q99708 | protein_coding | deleterious(0.02) | possibly_damaging(0.879) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBBP8 | SNV | Missense_Mutation | c.2679N>T | p.Lys893Asn | p.K893N | Q99708 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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