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Gene: RAI14 |
Gene summary for RAI14 |
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Gene information | Species | Human | Gene symbol | RAI14 | Gene ID | 26064 |
Gene name | retinoic acid induced 14 | |
Gene Alias | NORPEG | |
Cytomap | 5p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9P0K7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26064 | RAI14 | CCI_1 | Human | Cervix | CC | 6.78e-15 | 1.28e+00 | 0.528 |
26064 | RAI14 | CCI_3 | Human | Cervix | CC | 2.76e-10 | 7.80e-01 | 0.516 |
26064 | RAI14 | sample3 | Human | Cervix | CC | 4.97e-02 | 1.27e-01 | 0.1387 |
26064 | RAI14 | LZE2D | Human | Esophagus | HGIN | 4.67e-03 | 5.08e-01 | 0.0642 |
26064 | RAI14 | LZE4T | Human | Esophagus | ESCC | 3.31e-16 | 5.33e-01 | 0.0811 |
26064 | RAI14 | LZE5T | Human | Esophagus | ESCC | 4.59e-15 | 1.04e+00 | 0.0514 |
26064 | RAI14 | LZE7T | Human | Esophagus | ESCC | 1.00e-05 | 4.02e-01 | 0.0667 |
26064 | RAI14 | LZE8T | Human | Esophagus | ESCC | 7.52e-11 | 3.67e-01 | 0.067 |
26064 | RAI14 | LZE20T | Human | Esophagus | ESCC | 4.01e-42 | 1.65e+00 | 0.0662 |
26064 | RAI14 | LZE22T | Human | Esophagus | ESCC | 7.82e-13 | 9.19e-01 | 0.068 |
26064 | RAI14 | LZE24T | Human | Esophagus | ESCC | 1.04e-02 | 2.37e-01 | 0.0596 |
26064 | RAI14 | LZE6T | Human | Esophagus | ESCC | 8.91e-20 | 1.09e+00 | 0.0845 |
26064 | RAI14 | P1T-E | Human | Esophagus | ESCC | 1.02e-07 | 4.51e-01 | 0.0875 |
26064 | RAI14 | P2T-E | Human | Esophagus | ESCC | 9.10e-36 | 8.18e-01 | 0.1177 |
26064 | RAI14 | P4T-E | Human | Esophagus | ESCC | 1.71e-13 | 5.00e-01 | 0.1323 |
26064 | RAI14 | P5T-E | Human | Esophagus | ESCC | 7.34e-18 | 4.15e-01 | 0.1327 |
26064 | RAI14 | P8T-E | Human | Esophagus | ESCC | 5.96e-54 | 1.01e+00 | 0.0889 |
26064 | RAI14 | P9T-E | Human | Esophagus | ESCC | 1.06e-19 | 5.79e-01 | 0.1131 |
26064 | RAI14 | P10T-E | Human | Esophagus | ESCC | 1.47e-75 | 1.27e+00 | 0.116 |
26064 | RAI14 | P11T-E | Human | Esophagus | ESCC | 5.47e-19 | 7.19e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAI14 | insertion | Frame_Shift_Ins | novel | c.818_819insA | p.Arg276ThrfsTer15 | p.R276Tfs*15 | Q9P0K7 | protein_coding | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
RAI14 | SNV | Missense_Mutation | novel | c.544N>G | p.Asn182Asp | p.N182D | Q9P0K7 | protein_coding | tolerated(0.08) | probably_damaging(0.997) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RAI14 | SNV | Missense_Mutation | novel | c.972N>C | p.Glu324Asp | p.E324D | Q9P0K7 | protein_coding | tolerated(0.36) | benign(0.01) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAI14 | SNV | Missense_Mutation | rs576334657 | c.2423N>T | p.Ser808Leu | p.S808L | Q9P0K7 | protein_coding | tolerated(0.32) | benign(0.007) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RAI14 | SNV | Missense_Mutation | c.1231G>T | p.Asp411Tyr | p.D411Y | Q9P0K7 | protein_coding | deleterious(0.01) | benign(0.439) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAI14 | SNV | Missense_Mutation | novel | c.1658N>C | p.Lys553Thr | p.K553T | Q9P0K7 | protein_coding | tolerated(0.13) | benign(0.157) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RAI14 | SNV | Missense_Mutation | novel | c.356N>G | p.Asp119Gly | p.D119G | Q9P0K7 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RAI14 | SNV | Missense_Mutation | novel | c.1537N>A | p.Leu513Ile | p.L513I | Q9P0K7 | protein_coding | tolerated(0.1) | possibly_damaging(0.882) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RAI14 | SNV | Missense_Mutation | novel | c.2009N>A | p.Ser670Tyr | p.S670Y | Q9P0K7 | protein_coding | deleterious(0.01) | possibly_damaging(0.8) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RAI14 | SNV | Missense_Mutation | rs749996123 | c.484G>A | p.Ala162Thr | p.A162T | Q9P0K7 | protein_coding | tolerated(0.06) | benign(0.111) | TCGA-F4-6459-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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