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Gene: RAB40B |
Gene summary for RAB40B |
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Gene information | Species | Human | Gene symbol | RAB40B | Gene ID | 10966 |
Gene name | RAB40B, member RAS oncogene family | |
Gene Alias | RAR | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q12829 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10966 | RAB40B | LZE4T | Human | Esophagus | ESCC | 3.07e-02 | 1.08e-01 | 0.0811 |
10966 | RAB40B | LZE5T | Human | Esophagus | ESCC | 1.92e-02 | 2.58e-01 | 0.0514 |
10966 | RAB40B | LZE7T | Human | Esophagus | ESCC | 1.15e-04 | 3.57e-01 | 0.0667 |
10966 | RAB40B | LZE24T | Human | Esophagus | ESCC | 7.26e-30 | 1.02e+00 | 0.0596 |
10966 | RAB40B | LZE21T | Human | Esophagus | ESCC | 2.91e-02 | 5.53e-01 | 0.0655 |
10966 | RAB40B | P1T-E | Human | Esophagus | ESCC | 1.92e-05 | 3.90e-01 | 0.0875 |
10966 | RAB40B | P2T-E | Human | Esophagus | ESCC | 1.29e-34 | 6.39e-01 | 0.1177 |
10966 | RAB40B | P4T-E | Human | Esophagus | ESCC | 4.22e-14 | 3.88e-01 | 0.1323 |
10966 | RAB40B | P5T-E | Human | Esophagus | ESCC | 2.06e-09 | 2.13e-01 | 0.1327 |
10966 | RAB40B | P8T-E | Human | Esophagus | ESCC | 2.10e-20 | 3.51e-01 | 0.0889 |
10966 | RAB40B | P9T-E | Human | Esophagus | ESCC | 2.34e-13 | 4.01e-01 | 0.1131 |
10966 | RAB40B | P10T-E | Human | Esophagus | ESCC | 2.06e-20 | 2.21e-01 | 0.116 |
10966 | RAB40B | P11T-E | Human | Esophagus | ESCC | 6.51e-04 | 2.31e-01 | 0.1426 |
10966 | RAB40B | P12T-E | Human | Esophagus | ESCC | 4.14e-38 | 9.36e-01 | 0.1122 |
10966 | RAB40B | P15T-E | Human | Esophagus | ESCC | 1.84e-26 | 6.21e-01 | 0.1149 |
10966 | RAB40B | P16T-E | Human | Esophagus | ESCC | 6.37e-35 | 7.35e-01 | 0.1153 |
10966 | RAB40B | P19T-E | Human | Esophagus | ESCC | 2.68e-04 | 2.10e-01 | 0.1662 |
10966 | RAB40B | P20T-E | Human | Esophagus | ESCC | 1.46e-06 | 6.72e-02 | 0.1124 |
10966 | RAB40B | P21T-E | Human | Esophagus | ESCC | 1.50e-19 | 2.84e-01 | 0.1617 |
10966 | RAB40B | P22T-E | Human | Esophagus | ESCC | 3.35e-23 | 4.23e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:19019987 | Esophagus | ESCC | toxin transport | 28/8552 | 40/18723 | 1.61e-03 | 7.50e-03 | 28 |
GO:007265921 | Liver | HCC | protein localization to plasma membrane | 177/7958 | 284/18723 | 1.02e-11 | 4.18e-10 | 177 |
GO:199077821 | Liver | HCC | protein localization to cell periphery | 200/7958 | 333/18723 | 6.07e-11 | 2.23e-09 | 200 |
GO:007265918 | Oral cavity | OSCC | protein localization to plasma membrane | 169/7305 | 284/18723 | 1.69e-12 | 7.21e-11 | 169 |
GO:199077816 | Oral cavity | OSCC | protein localization to cell periphery | 190/7305 | 333/18723 | 1.46e-11 | 5.13e-10 | 190 |
GO:19019986 | Oral cavity | OSCC | toxin transport | 25/7305 | 40/18723 | 2.22e-03 | 1.00e-02 | 25 |
GO:007265919 | Oral cavity | LP | protein localization to plasma membrane | 119/4623 | 284/18723 | 1.11e-10 | 6.44e-09 | 119 |
GO:199077817 | Oral cavity | LP | protein localization to cell periphery | 133/4623 | 333/18723 | 4.42e-10 | 2.21e-08 | 133 |
GO:190199812 | Oral cavity | LP | toxin transport | 19/4623 | 40/18723 | 1.44e-03 | 1.14e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAB40B | SNV | Missense_Mutation | rs114060137 | c.253N>T | p.Arg85Trp | p.R85W | Q12829 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAB40B | SNV | Missense_Mutation | novel | c.794N>T | p.Ser265Ile | p.S265I | Q12829 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.899) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RAB40B | SNV | Missense_Mutation | novel | c.116N>T | p.Ala39Val | p.A39V | Q12829 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RAB40B | insertion | Frame_Shift_Ins | rs764520009 | c.801dupC | p.Lys268GlnfsTer96 | p.K268Qfs*96 | Q12829 | protein_coding | TCGA-AJ-A3NC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RAB40B | deletion | Frame_Shift_Del | novel | c.801delN | p.Asn269ThrfsTer83 | p.N269Tfs*83 | Q12829 | protein_coding | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | ||
RAB40B | deletion | Frame_Shift_Del | novel | c.672delN | p.Phe225SerfsTer7 | p.F225Sfs*7 | Q12829 | protein_coding | TCGA-DD-A115-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Chemotherapy | unknown | SD | ||
RAB40B | SNV | Missense_Mutation | c.163N>T | p.Thr55Ser | p.T55S | Q12829 | protein_coding | deleterious(0.03) | probably_damaging(0.988) | TCGA-73-4659-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | alimta | PD | |
RAB40B | SNV | Missense_Mutation | rs149210378 | c.544C>T | p.Arg182Trp | p.R182W | Q12829 | protein_coding | tolerated(0.14) | benign(0.006) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD |
RAB40B | SNV | Missense_Mutation | novel | c.619C>T | p.His207Tyr | p.H207Y | Q12829 | protein_coding | tolerated_low_confidence(0.62) | benign(0.014) | TCGA-85-8071-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RAB40B | SNV | Missense_Mutation | rs750392311 | c.185G>A | p.Arg62Gln | p.R62Q | Q12829 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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