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Gene: RAB2B |
Gene summary for RAB2B |
Gene summary. |
Gene information | Species | Human | Gene symbol | RAB2B | Gene ID | 84932 |
Gene name | RAB2B, member RAS oncogene family | |
Gene Alias | RAB2B | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B4DUD4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84932 | RAB2B | LZE4T | Human | Esophagus | ESCC | 7.41e-10 | 3.18e-01 | 0.0811 |
84932 | RAB2B | LZE20T | Human | Esophagus | ESCC | 2.71e-04 | 1.07e-01 | 0.0662 |
84932 | RAB2B | LZE24T | Human | Esophagus | ESCC | 2.71e-16 | 1.12e-01 | 0.0596 |
84932 | RAB2B | LZE6T | Human | Esophagus | ESCC | 1.82e-02 | 5.98e-02 | 0.0845 |
84932 | RAB2B | P1T-E | Human | Esophagus | ESCC | 2.40e-02 | 6.61e-02 | 0.0875 |
84932 | RAB2B | P2T-E | Human | Esophagus | ESCC | 1.33e-10 | 8.88e-02 | 0.1177 |
84932 | RAB2B | P4T-E | Human | Esophagus | ESCC | 1.99e-06 | 1.04e-01 | 0.1323 |
84932 | RAB2B | P5T-E | Human | Esophagus | ESCC | 3.11e-07 | 7.02e-02 | 0.1327 |
84932 | RAB2B | P8T-E | Human | Esophagus | ESCC | 2.63e-12 | 2.02e-01 | 0.0889 |
84932 | RAB2B | P9T-E | Human | Esophagus | ESCC | 1.12e-09 | 4.93e-02 | 0.1131 |
84932 | RAB2B | P10T-E | Human | Esophagus | ESCC | 8.23e-14 | 2.11e-01 | 0.116 |
84932 | RAB2B | P11T-E | Human | Esophagus | ESCC | 1.87e-11 | 2.83e-01 | 0.1426 |
84932 | RAB2B | P12T-E | Human | Esophagus | ESCC | 1.14e-15 | 3.93e-01 | 0.1122 |
84932 | RAB2B | P15T-E | Human | Esophagus | ESCC | 6.19e-15 | 2.72e-01 | 0.1149 |
84932 | RAB2B | P16T-E | Human | Esophagus | ESCC | 5.90e-14 | 1.16e-01 | 0.1153 |
84932 | RAB2B | P21T-E | Human | Esophagus | ESCC | 7.06e-05 | 6.94e-02 | 0.1617 |
84932 | RAB2B | P22T-E | Human | Esophagus | ESCC | 2.59e-06 | 6.11e-02 | 0.1236 |
84932 | RAB2B | P23T-E | Human | Esophagus | ESCC | 2.07e-11 | 1.70e-01 | 0.108 |
84932 | RAB2B | P26T-E | Human | Esophagus | ESCC | 9.38e-09 | 2.20e-01 | 0.1276 |
84932 | RAB2B | P27T-E | Human | Esophagus | ESCC | 3.55e-20 | 3.23e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAB2B | SNV | Missense_Mutation | c.611N>T | p.Arg204Leu | p.R204L | Q8WUD1 | protein_coding | tolerated(0.29) | benign(0) | TCGA-CV-6940-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RAB2B | SNV | Missense_Mutation | c.64C>T | p.Leu22Phe | p.L22F | Q8WUD1 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAB2B | SNV | Missense_Mutation | c.380N>T | p.Arg127Met | p.R127M | Q8WUD1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RAB2B | SNV | Missense_Mutation | c.350N>C | p.Ile117Thr | p.I117T | Q8WUD1 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-HU-8249-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | CR | |
RAB2B | insertion | In_Frame_Ins | novel | c.431_432insTAT | p.Ile144dup | p.I144dup | Q8WUD1 | protein_coding | TCGA-KB-A93J-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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