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Gene: PTMA |
Gene summary for PTMA |
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Gene information | Species | Human | Gene symbol | PTMA | Gene ID | 5757 |
Gene name | prothymosin alpha | |
Gene Alias | TMSA | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P06454 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5757 | PTMA | CCI_1 | Human | Cervix | CC | 4.18e-55 | -1.66e+00 | 0.528 |
5757 | PTMA | CCI_2 | Human | Cervix | CC | 9.00e-12 | -3.19e-01 | 0.5249 |
5757 | PTMA | CCI_3 | Human | Cervix | CC | 3.40e-30 | -1.05e+00 | 0.516 |
5757 | PTMA | CCII_1 | Human | Cervix | CC | 2.35e-106 | -1.80e+00 | 0.3249 |
5757 | PTMA | H2 | Human | Cervix | HSIL_HPV | 4.93e-21 | -2.70e-01 | 0.0632 |
5757 | PTMA | L1 | Human | Cervix | CC | 5.45e-08 | -2.60e-01 | 0.0802 |
5757 | PTMA | T1 | Human | Cervix | CC | 7.66e-22 | -2.52e-01 | 0.0918 |
5757 | PTMA | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.41e-47 | 1.19e+00 | 0.0155 |
5757 | PTMA | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.50e-26 | 1.47e+00 | -0.1808 |
5757 | PTMA | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.34e-10 | 1.16e+00 | 0.0216 |
5757 | PTMA | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.02e-39 | 2.03e+00 | -0.0811 |
5757 | PTMA | HTA11_78_2000001011 | Human | Colorectum | AD | 3.62e-42 | 1.80e+00 | -0.1088 |
5757 | PTMA | HTA11_347_2000001011 | Human | Colorectum | AD | 8.38e-98 | 2.54e+00 | -0.1954 |
5757 | PTMA | HTA11_411_2000001011 | Human | Colorectum | SER | 6.85e-19 | 1.97e+00 | -0.2602 |
5757 | PTMA | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.55e-05 | 1.58e+00 | -0.2196 |
5757 | PTMA | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.47e-18 | 1.80e+00 | -0.1207 |
5757 | PTMA | HTA11_83_2000001011 | Human | Colorectum | SER | 1.20e-34 | 2.04e+00 | -0.1526 |
5757 | PTMA | HTA11_696_2000001011 | Human | Colorectum | AD | 5.22e-62 | 1.92e+00 | -0.1464 |
5757 | PTMA | HTA11_866_2000001011 | Human | Colorectum | AD | 8.44e-54 | 1.70e+00 | -0.1001 |
5757 | PTMA | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.60e-47 | 2.61e+00 | -0.059 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTMA | SNV | Missense_Mutation | c.88N>A | p.Gly30Arg | p.G30R | P06454 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
PTMA | SNV | Missense_Mutation | novel | c.109N>T | p.Gly37Trp | p.G37W | P06454 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-77-A5GF-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5757 | PTMA | NA | THYMALFASIN | THYMALFASIN |
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