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Gene: PTBP1 |
Gene summary for PTBP1 |
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Gene information | Species | Human | Gene symbol | PTBP1 | Gene ID | 5725 |
Gene name | polypyrimidine tract binding protein 1 | |
Gene Alias | HNRNP-I | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P26599 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5725 | PTBP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.14e-03 | 2.51e-01 | 0.0155 |
5725 | PTBP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.08e-05 | 4.21e-01 | -0.1808 |
5725 | PTBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.60e-08 | 6.11e-01 | -0.0811 |
5725 | PTBP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.54e-16 | 5.81e-01 | -0.1954 |
5725 | PTBP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.34e-04 | 8.47e-01 | -0.2602 |
5725 | PTBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.21e-10 | 6.08e-01 | -0.1464 |
5725 | PTBP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.05e-13 | 8.09e-01 | -0.059 |
5725 | PTBP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.23e-03 | 5.24e-01 | -0.1706 |
5725 | PTBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.14e-06 | 5.16e-01 | 0.096 |
5725 | PTBP1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.18e-02 | 6.75e-01 | 0.0446 |
5725 | PTBP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.82e-02 | 5.61e-01 | 0.0131 |
5725 | PTBP1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.68e-04 | 6.59e-01 | -0.0177 |
5725 | PTBP1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 6.19e-09 | 9.92e-01 | 0.0171 |
5725 | PTBP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.61e-17 | 7.17e-01 | 0.0674 |
5725 | PTBP1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.73e-04 | 7.95e-01 | -0.0124 |
5725 | PTBP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.32e-16 | 7.62e-01 | 0.294 |
5725 | PTBP1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.43e-06 | 1.13e+00 | 0.3487 |
5725 | PTBP1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.18e-24 | 1.15e+00 | 0.281 |
5725 | PTBP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.57e-14 | 7.86e-01 | 0.3859 |
5725 | PTBP1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.45e-05 | 5.55e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0043484 | Colorectum | AD | regulation of RNA splicing | 70/3918 | 148/18723 | 6.47e-13 | 1.16e-10 | 70 |
GO:0048024 | Colorectum | AD | regulation of mRNA splicing, via spliceosome | 50/3918 | 101/18723 | 1.62e-10 | 1.56e-08 | 50 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:0019080 | Colorectum | AD | viral gene expression | 42/3918 | 94/18723 | 1.90e-07 | 8.02e-06 | 42 |
GO:0000380 | Colorectum | AD | alternative mRNA splicing, via spliceosome | 33/3918 | 77/18723 | 1.13e-05 | 2.55e-04 | 33 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:1903312 | Colorectum | AD | negative regulation of mRNA metabolic process | 37/3918 | 92/18723 | 1.95e-05 | 4.01e-04 | 37 |
GO:0033119 | Colorectum | AD | negative regulation of RNA splicing | 15/3918 | 25/18723 | 2.37e-05 | 4.62e-04 | 15 |
GO:0000381 | Colorectum | AD | regulation of alternative mRNA splicing, via spliceosome | 27/3918 | 60/18723 | 2.41e-05 | 4.66e-04 | 27 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:0035303 | Colorectum | AD | regulation of dephosphorylation | 46/3918 | 128/18723 | 6.20e-05 | 1.04e-03 | 46 |
GO:0075522 | Colorectum | AD | IRES-dependent viral translational initiation | 8/3918 | 11/18723 | 3.26e-04 | 3.85e-03 | 8 |
GO:0019081 | Colorectum | AD | viral translation | 10/3918 | 16/18723 | 3.64e-04 | 4.22e-03 | 10 |
GO:0035304 | Colorectum | AD | regulation of protein dephosphorylation | 33/3918 | 90/18723 | 4.23e-04 | 4.77e-03 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTBP1 | SNV | Missense_Mutation | rs775074950 | c.700N>A | p.Ala234Thr | p.A234T | P26599 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PTBP1 | SNV | Missense_Mutation | c.1207N>A | p.Ala403Thr | p.A403T | P26599 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
PTBP1 | SNV | Missense_Mutation | c.700G>T | p.Ala234Ser | p.A234S | P26599 | protein_coding | deleterious(0.03) | probably_damaging(0.967) | TCGA-F4-6463-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PTBP1 | SNV | Missense_Mutation | c.199N>T | p.Pro67Ser | p.P67S | P26599 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
PTBP1 | SNV | Missense_Mutation | novel | c.1379C>A | p.Pro460His | p.P460H | P26599 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTBP1 | SNV | Missense_Mutation | novel | c.315N>T | p.Glu105Asp | p.E105D | P26599 | protein_coding | tolerated(0.09) | benign(0.12) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTBP1 | SNV | Missense_Mutation | rs746206692 | c.829C>T | p.Arg277Cys | p.R277C | P26599 | protein_coding | deleterious(0.03) | possibly_damaging(0.907) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PTBP1 | SNV | Missense_Mutation | rs374567155 | c.104N>T | p.Ser35Leu | p.S35L | P26599 | protein_coding | tolerated(0.09) | benign(0.011) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTBP1 | SNV | Missense_Mutation | novel | c.1182N>T | p.Lys394Asn | p.K394N | P26599 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
PTBP1 | SNV | Missense_Mutation | rs201221864 | c.686N>T | p.Ala229Val | p.A229V | P26599 | protein_coding | deleterious(0.01) | benign(0.013) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5725 | PTBP1 | DRUGGABLE GENOME | MMV085203 | CHEMBL586031 | ||
5725 | PTBP1 | DRUGGABLE GENOME | DNDI1417941 | CHEMBL2095095 | ||
5725 | PTBP1 | DRUGGABLE GENOME | GNF-PF-4418 | CHEMBL604321 | ||
5725 | PTBP1 | DRUGGABLE GENOME | SJ000154295 | CHEMBL578502 | ||
5725 | PTBP1 | DRUGGABLE GENOME | ELLIPTECINE | ELLIPTECINE | ||
5725 | PTBP1 | DRUGGABLE GENOME | SJ000044511 | CHEMBL592124 |
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