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Gene: PRRG1 |
Gene summary for PRRG1 |
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Gene information | Species | Human | Gene symbol | PRRG1 | Gene ID | 5638 |
Gene name | proline rich and Gla domain 1 | |
Gene Alias | PRGP1 | |
Cytomap | Xp21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O14668 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5638 | PRRG1 | male-WTA | Human | Thyroid | PTC | 2.11e-25 | 2.88e-01 | 0.1037 |
5638 | PRRG1 | PTC01 | Human | Thyroid | PTC | 4.70e-13 | 1.85e-01 | 0.1899 |
5638 | PRRG1 | PTC04 | Human | Thyroid | PTC | 9.16e-04 | 1.03e-01 | 0.1927 |
5638 | PRRG1 | PTC05 | Human | Thyroid | PTC | 1.06e-15 | 5.80e-01 | 0.2065 |
5638 | PRRG1 | PTC06 | Human | Thyroid | PTC | 3.13e-29 | 5.30e-01 | 0.2057 |
5638 | PRRG1 | PTC07 | Human | Thyroid | PTC | 3.47e-25 | 4.55e-01 | 0.2044 |
5638 | PRRG1 | ATC13 | Human | Thyroid | ATC | 1.32e-06 | 8.76e-02 | 0.34 |
5638 | PRRG1 | ATC2 | Human | Thyroid | ATC | 6.70e-09 | 5.84e-01 | 0.34 |
5638 | PRRG1 | ATC5 | Human | Thyroid | ATC | 1.09e-02 | 9.59e-02 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRRG1 | SNV | Missense_Mutation | c.123C>A | p.Phe41Leu | p.F41L | O14668 | protein_coding | tolerated(0.45) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PRRG1 | SNV | Missense_Mutation | c.515N>T | p.Tyr172Phe | p.Y172F | O14668 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
PRRG1 | deletion | Frame_Shift_Del | c.368delC | p.Pro123LeufsTer30 | p.P123Lfs*30 | O14668 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
PRRG1 | SNV | Missense_Mutation | novel | c.50G>A | p.Arg17His | p.R17H | O14668 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRRG1 | SNV | Missense_Mutation | novel | c.484C>T | p.Arg162Cys | p.R162C | O14668 | protein_coding | deleterious(0.05) | benign(0.001) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRRG1 | SNV | Missense_Mutation | novel | c.199N>C | p.Ala67Pro | p.A67P | O14668 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PRRG1 | SNV | Missense_Mutation | novel | c.469N>T | p.Asp157Tyr | p.D157Y | O14668 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRRG1 | SNV | Missense_Mutation | novel | c.316N>A | p.Leu106Ile | p.L106I | O14668 | protein_coding | deleterious(0.04) | benign(0.3) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
PRRG1 | SNV | Missense_Mutation | novel | c.634N>T | p.Pro212Ser | p.P212S | O14668 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.994) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
PRRG1 | SNV | Missense_Mutation | novel | c.634C>T | p.Pro212Ser | p.P212S | O14668 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.994) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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