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Gene: PRR5L |
Gene summary for PRR5L |
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Gene information | Species | Human | Gene symbol | PRR5L | Gene ID | 79899 |
Gene name | proline rich 5 like | |
Gene Alias | PROTOR2 | |
Cytomap | 11p13-p12 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | B3KNU3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79899 | PRR5L | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.90e-10 | -5.55e-01 | 0.0155 |
79899 | PRR5L | HTA11_347_2000001011 | Human | Colorectum | AD | 4.07e-15 | 7.35e-01 | -0.1954 |
79899 | PRR5L | HTA11_866_3004761011 | Human | Colorectum | AD | 3.25e-03 | -4.51e-01 | 0.096 |
79899 | PRR5L | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.16e-11 | -5.07e-01 | 0.0674 |
79899 | PRR5L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.78e-03 | -3.19e-01 | 0.294 |
79899 | PRR5L | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.66e-13 | -5.17e-01 | 0.3005 |
79899 | PRR5L | A015-C-203 | Human | Colorectum | FAP | 7.49e-22 | -4.74e-01 | -0.1294 |
79899 | PRR5L | A015-C-204 | Human | Colorectum | FAP | 2.67e-03 | -2.73e-01 | -0.0228 |
79899 | PRR5L | A002-C-201 | Human | Colorectum | FAP | 6.14e-08 | -3.79e-01 | 0.0324 |
79899 | PRR5L | A001-C-119 | Human | Colorectum | FAP | 1.14e-12 | -6.26e-01 | -0.1557 |
79899 | PRR5L | A001-C-108 | Human | Colorectum | FAP | 9.09e-12 | -3.55e-01 | -0.0272 |
79899 | PRR5L | A002-C-205 | Human | Colorectum | FAP | 5.74e-14 | -4.11e-01 | -0.1236 |
79899 | PRR5L | A001-C-104 | Human | Colorectum | FAP | 6.24e-03 | -2.93e-01 | 0.0184 |
79899 | PRR5L | A015-C-005 | Human | Colorectum | FAP | 1.23e-04 | -3.95e-01 | -0.0336 |
79899 | PRR5L | A015-C-006 | Human | Colorectum | FAP | 6.47e-14 | -6.01e-01 | -0.0994 |
79899 | PRR5L | A015-C-106 | Human | Colorectum | FAP | 2.06e-08 | -3.34e-01 | -0.0511 |
79899 | PRR5L | A002-C-114 | Human | Colorectum | FAP | 1.84e-13 | -4.64e-01 | -0.1561 |
79899 | PRR5L | A015-C-104 | Human | Colorectum | FAP | 4.31e-23 | -4.61e-01 | -0.1899 |
79899 | PRR5L | A001-C-014 | Human | Colorectum | FAP | 2.28e-12 | -3.62e-01 | 0.0135 |
79899 | PRR5L | A002-C-016 | Human | Colorectum | FAP | 5.14e-14 | -3.25e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
GO:0090316 | Colorectum | AD | positive regulation of intracellular protein transport | 62/3918 | 160/18723 | 1.82e-07 | 7.79e-06 | 62 |
GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04150 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa041501 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa041504 | Oral cavity | OSCC | mTOR signaling pathway | 90/3704 | 156/8465 | 2.87e-04 | 9.15e-04 | 4.66e-04 | 90 |
hsa0415012 | Oral cavity | OSCC | mTOR signaling pathway | 90/3704 | 156/8465 | 2.87e-04 | 9.15e-04 | 4.66e-04 | 90 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRR5L | SNV | Missense_Mutation | c.533T>C | p.Leu178Pro | p.L178P | Q6MZQ0 | protein_coding | tolerated(0.28) | benign(0.188) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PRR5L | SNV | Missense_Mutation | c.698C>T | p.Pro233Leu | p.P233L | Q6MZQ0 | protein_coding | tolerated(0.1) | benign(0.022) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PRR5L | SNV | Missense_Mutation | c.781N>G | p.Ser261Gly | p.S261G | Q6MZQ0 | protein_coding | tolerated(0.09) | benign(0) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRR5L | SNV | Missense_Mutation | c.185A>G | p.Asn62Ser | p.N62S | Q6MZQ0 | protein_coding | tolerated(0.39) | benign(0.112) | TCGA-D5-5541-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | calcium | SD | |
PRR5L | deletion | Frame_Shift_Del | c.200delG | p.Gly67ValfsTer11 | p.G67Vfs*11 | Q6MZQ0 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PRR5L | SNV | Missense_Mutation | novel | c.131N>A | p.Ala44Asp | p.A44D | Q6MZQ0 | protein_coding | deleterious(0.05) | benign(0.441) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PRR5L | SNV | Missense_Mutation | rs771531021 | c.862C>T | p.Arg288Trp | p.R288W | Q6MZQ0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
PRR5L | SNV | Missense_Mutation | c.164N>T | p.Ser55Ile | p.S55I | Q6MZQ0 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRR5L | SNV | Missense_Mutation | novel | c.476N>C | p.Leu159Pro | p.L159P | Q6MZQ0 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRR5L | SNV | Missense_Mutation | c.490N>T | p.Asp164Tyr | p.D164Y | Q6MZQ0 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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