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Gene: PRKCH |
Gene summary for PRKCH |
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Gene information | Species | Human | Gene symbol | PRKCH | Gene ID | 5583 |
Gene name | protein kinase C eta | |
Gene Alias | PKC-L | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0002253 | UniProtAcc | P24723 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5583 | PRKCH | CCI_1 | Human | Cervix | CC | 1.51e-21 | 1.06e+00 | 0.528 |
5583 | PRKCH | CCI_2 | Human | Cervix | CC | 2.05e-17 | 1.52e+00 | 0.5249 |
5583 | PRKCH | CCI_3 | Human | Cervix | CC | 5.19e-22 | 8.49e-01 | 0.516 |
5583 | PRKCH | sample3 | Human | Cervix | CC | 1.59e-07 | 1.60e-01 | 0.1387 |
5583 | PRKCH | AEH-subject1 | Human | Endometrium | AEH | 7.18e-18 | 4.42e-01 | -0.3059 |
5583 | PRKCH | AEH-subject2 | Human | Endometrium | AEH | 8.46e-10 | 3.60e-01 | -0.2525 |
5583 | PRKCH | AEH-subject3 | Human | Endometrium | AEH | 1.03e-04 | 2.83e-01 | -0.2576 |
5583 | PRKCH | AEH-subject4 | Human | Endometrium | AEH | 9.73e-17 | 5.34e-01 | -0.2657 |
5583 | PRKCH | AEH-subject5 | Human | Endometrium | AEH | 1.82e-28 | 6.65e-01 | -0.2953 |
5583 | PRKCH | EEC-subject1 | Human | Endometrium | EEC | 1.04e-02 | 2.78e-01 | -0.2682 |
5583 | PRKCH | EEC-subject2 | Human | Endometrium | EEC | 2.73e-08 | 3.46e-01 | -0.2607 |
5583 | PRKCH | EEC-subject4 | Human | Endometrium | EEC | 4.06e-18 | 5.31e-01 | -0.2571 |
5583 | PRKCH | EEC-subject5 | Human | Endometrium | EEC | 4.57e-16 | 4.88e-01 | -0.249 |
5583 | PRKCH | LZE4T | Human | Esophagus | ESCC | 7.68e-07 | 2.14e-01 | 0.0811 |
5583 | PRKCH | LZE7T | Human | Esophagus | ESCC | 5.98e-07 | 3.91e-01 | 0.0667 |
5583 | PRKCH | LZE8T | Human | Esophagus | ESCC | 1.57e-02 | 1.05e-01 | 0.067 |
5583 | PRKCH | LZE20T | Human | Esophagus | ESCC | 4.19e-08 | 2.57e-01 | 0.0662 |
5583 | PRKCH | LZE22T | Human | Esophagus | ESCC | 1.07e-04 | 5.00e-01 | 0.068 |
5583 | PRKCH | LZE24T | Human | Esophagus | ESCC | 2.47e-17 | 2.70e-01 | 0.0596 |
5583 | PRKCH | LZE6T | Human | Esophagus | ESCC | 1.39e-04 | 2.55e-01 | 0.0845 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00302164 | Cervix | CC | keratinocyte differentiation | 42/2311 | 139/18723 | 1.74e-08 | 1.28e-06 | 42 |
GO:00452169 | Cervix | CC | cell-cell junction organization | 53/2311 | 200/18723 | 3.83e-08 | 2.53e-06 | 53 |
GO:00099137 | Cervix | CC | epidermal cell differentiation | 53/2311 | 202/18723 | 5.48e-08 | 3.25e-06 | 53 |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:19043779 | Cervix | CC | positive regulation of protein localization to cell periphery | 24/2311 | 69/18723 | 1.21e-06 | 4.15e-05 | 24 |
GO:00070439 | Cervix | CC | cell-cell junction assembly | 39/2311 | 146/18723 | 1.86e-06 | 5.94e-05 | 39 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:00456822 | Cervix | CC | regulation of epidermis development | 22/2311 | 65/18723 | 5.56e-06 | 1.38e-04 | 22 |
GO:00107206 | Cervix | CC | positive regulation of cell development | 64/2311 | 298/18723 | 5.69e-06 | 1.41e-04 | 64 |
GO:19030788 | Cervix | CC | positive regulation of protein localization to plasma membrane | 21/2311 | 62/18723 | 8.91e-06 | 2.03e-04 | 21 |
GO:00456042 | Cervix | CC | regulation of epidermal cell differentiation | 20/2311 | 58/18723 | 1.07e-05 | 2.33e-04 | 20 |
GO:00432978 | Cervix | CC | apical junction assembly | 24/2311 | 78/18723 | 1.36e-05 | 2.73e-04 | 24 |
GO:19054778 | Cervix | CC | positive regulation of protein localization to membrane | 29/2311 | 106/18723 | 2.29e-05 | 4.01e-04 | 29 |
GO:00181057 | Cervix | CC | peptidyl-serine phosphorylation | 63/2311 | 315/18723 | 6.65e-05 | 9.47e-04 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa042704 | Oral cavity | NEOLP | Vascular smooth muscle contraction | 30/1112 | 134/8465 | 2.06e-03 | 8.97e-03 | 5.64e-03 | 30 |
hsa0427011 | Oral cavity | NEOLP | Vascular smooth muscle contraction | 30/1112 | 134/8465 | 2.06e-03 | 8.97e-03 | 5.64e-03 | 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRKCH | insertion | Frame_Shift_Ins | novel | c.1504_1505insC | p.Lys502ThrfsTer45 | p.K502Tfs*45 | P24723 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
PRKCH | insertion | Frame_Shift_Ins | novel | c.1505_1506insTGGTGTGTGTGCAGTGTGTGTGT | p.Lys502AsnfsTer42 | p.K502Nfs*42 | P24723 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
PRKCH | SNV | Missense_Mutation | c.706N>T | p.Ala236Ser | p.A236S | P24723 | protein_coding | tolerated(0.77) | benign(0) | TCGA-AA-3502-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PRKCH | SNV | Missense_Mutation | novel | c.299N>G | p.Asn100Ser | p.N100S | P24723 | protein_coding | tolerated(0.14) | probably_damaging(0.967) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRKCH | SNV | Missense_Mutation | rs754738854 | c.871G>A | p.Val291Met | p.V291M | P24723 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AA-3989-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
PRKCH | SNV | Missense_Mutation | novel | c.361N>C | p.Trp121Arg | p.W121R | P24723 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRKCH | SNV | Missense_Mutation | rs746996721 | c.1654N>A | p.Ala552Thr | p.A552T | P24723 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
PRKCH | SNV | Missense_Mutation | c.1762N>C | p.Phe588Leu | p.F588L | P24723 | protein_coding | tolerated(0.6) | benign(0.136) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRKCH | SNV | Missense_Mutation | c.1655C>T | p.Ala552Val | p.A552V | P24723 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PRKCH | SNV | Missense_Mutation | novel | c.808A>G | p.Met270Val | p.M270V | P24723 | protein_coding | tolerated(1) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | 249565629 | SOTRASTAURIN | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL3545332 | CEP-2563 | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | BRYOSTATIN-1 | |||
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | BRYOSTATIN | BRYOSTATIN | ||
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL494089 | GSK-690693 | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL565612 | SOTRASTAURIN | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | INGENOL MEBUTATE | |||
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL608533 | MIDOSTAURIN | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | 249565822 | BALANOL | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | SOPHORETIN | QUERCETIN |
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