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Gene: PRICKLE1 |
Gene summary for PRICKLE1 |
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Gene information | Species | Human | Gene symbol | PRICKLE1 | Gene ID | 144165 |
Gene name | prickle planar cell polarity protein 1 | |
Gene Alias | EPM1B | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0001568 | UniProtAcc | A0A024R0W7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
144165 | PRICKLE1 | LZE4T | Human | Esophagus | ESCC | 4.04e-09 | 3.64e-01 | 0.0811 |
144165 | PRICKLE1 | P2T-E | Human | Esophagus | ESCC | 6.10e-04 | 1.23e-01 | 0.1177 |
144165 | PRICKLE1 | P5T-E | Human | Esophagus | ESCC | 3.64e-09 | 2.72e-01 | 0.1327 |
144165 | PRICKLE1 | P8T-E | Human | Esophagus | ESCC | 1.37e-02 | 1.07e-01 | 0.0889 |
144165 | PRICKLE1 | P9T-E | Human | Esophagus | ESCC | 1.42e-03 | 1.27e-01 | 0.1131 |
144165 | PRICKLE1 | P10T-E | Human | Esophagus | ESCC | 1.35e-47 | 8.17e-01 | 0.116 |
144165 | PRICKLE1 | P11T-E | Human | Esophagus | ESCC | 4.82e-04 | 3.21e-01 | 0.1426 |
144165 | PRICKLE1 | P12T-E | Human | Esophagus | ESCC | 2.13e-14 | 5.12e-01 | 0.1122 |
144165 | PRICKLE1 | P15T-E | Human | Esophagus | ESCC | 6.13e-03 | 1.83e-01 | 0.1149 |
144165 | PRICKLE1 | P16T-E | Human | Esophagus | ESCC | 2.20e-03 | 9.53e-02 | 0.1153 |
144165 | PRICKLE1 | P20T-E | Human | Esophagus | ESCC | 1.95e-14 | 4.01e-01 | 0.1124 |
144165 | PRICKLE1 | P21T-E | Human | Esophagus | ESCC | 5.80e-05 | 2.25e-02 | 0.1617 |
144165 | PRICKLE1 | P22T-E | Human | Esophagus | ESCC | 2.29e-12 | 3.23e-01 | 0.1236 |
144165 | PRICKLE1 | P23T-E | Human | Esophagus | ESCC | 1.98e-03 | 8.42e-02 | 0.108 |
144165 | PRICKLE1 | P26T-E | Human | Esophagus | ESCC | 1.15e-06 | 3.16e-01 | 0.1276 |
144165 | PRICKLE1 | P30T-E | Human | Esophagus | ESCC | 1.06e-08 | 5.17e-01 | 0.137 |
144165 | PRICKLE1 | P31T-E | Human | Esophagus | ESCC | 3.82e-21 | 4.98e-01 | 0.1251 |
144165 | PRICKLE1 | P32T-E | Human | Esophagus | ESCC | 1.32e-08 | 2.44e-01 | 0.1666 |
144165 | PRICKLE1 | P37T-E | Human | Esophagus | ESCC | 1.61e-09 | 2.14e-01 | 0.1371 |
144165 | PRICKLE1 | P42T-E | Human | Esophagus | ESCC | 9.24e-10 | 3.94e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:1903362111 | Esophagus | ESCC | regulation of cellular protein catabolic process | 188/8552 | 255/18723 | 5.12e-20 | 6.62e-18 | 188 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:1903050111 | Esophagus | ESCC | regulation of proteolysis involved in cellular protein catabolic process | 163/8552 | 221/18723 | 1.44e-17 | 1.27e-15 | 163 |
GO:0061136111 | Esophagus | ESCC | regulation of proteasomal protein catabolic process | 142/8552 | 187/18723 | 2.40e-17 | 2.00e-15 | 142 |
GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:0032434111 | Esophagus | ESCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 107/8552 | 134/18723 | 4.06e-16 | 2.93e-14 | 107 |
GO:2000058111 | Esophagus | ESCC | regulation of ubiquitin-dependent protein catabolic process | 125/8552 | 164/18723 | 1.17e-15 | 7.76e-14 | 125 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:1903364111 | Esophagus | ESCC | positive regulation of cellular protein catabolic process | 117/8552 | 155/18723 | 3.25e-14 | 1.66e-12 | 117 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0431021 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
hsa0431031 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRICKLE1 | SNV | Missense_Mutation | novel | c.880N>T | p.Leu294Phe | p.L294F | Q96MT3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A8QF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PRICKLE1 | SNV | Missense_Mutation | rs779314205 | c.2026N>T | p.Arg676Trp | p.R676W | Q96MT3 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRICKLE1 | SNV | Missense_Mutation | novel | c.986N>G | p.Asp329Gly | p.D329G | Q96MT3 | protein_coding | deleterious(0) | benign(0.282) | TCGA-A6-6142-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | PD |
PRICKLE1 | SNV | Missense_Mutation | rs372213429 | c.706N>T | p.Arg236Cys | p.R236C | Q96MT3 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRICKLE1 | SNV | Missense_Mutation | novel | c.593N>G | p.Ile198Ser | p.I198S | Q96MT3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRICKLE1 | SNV | Missense_Mutation | novel | c.1058N>T | p.Ser353Leu | p.S353L | Q96MT3 | protein_coding | tolerated(0.11) | benign(0.41) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRICKLE1 | SNV | Missense_Mutation | c.1558N>C | p.Ser520Pro | p.S520P | Q96MT3 | protein_coding | tolerated(0.16) | benign(0.043) | TCGA-AA-A00O-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PRICKLE1 | SNV | Missense_Mutation | c.2065N>A | p.Leu689Ile | p.L689I | Q96MT3 | protein_coding | deleterious(0.04) | benign(0.086) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PRICKLE1 | SNV | Missense_Mutation | c.1510N>A | p.His504Asn | p.H504N | Q96MT3 | protein_coding | tolerated(0.13) | benign(0.236) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PRICKLE1 | SNV | Missense_Mutation | c.349N>A | p.Leu117Met | p.L117M | Q96MT3 | protein_coding | deleterious(0.04) | probably_damaging(0.986) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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