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Gene: PRDX5 |
Gene summary for PRDX5 |
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Gene information | Species | Human | Gene symbol | PRDX5 | Gene ID | 25824 |
Gene name | peroxiredoxin 5 | |
Gene Alias | ACR1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P30044 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25824 | PRDX5 | GSM4909280 | Human | Breast | Precancer | 2.09e-02 | -6.13e-01 | 0.0305 |
25824 | PRDX5 | GSM4909282 | Human | Breast | IDC | 2.88e-02 | -2.19e-01 | -0.0288 |
25824 | PRDX5 | GSM4909285 | Human | Breast | IDC | 4.63e-04 | -1.16e-01 | 0.21 |
25824 | PRDX5 | GSM4909286 | Human | Breast | IDC | 4.22e-12 | -1.75e-01 | 0.1081 |
25824 | PRDX5 | GSM4909293 | Human | Breast | IDC | 8.99e-04 | -3.03e-02 | 0.1581 |
25824 | PRDX5 | GSM4909296 | Human | Breast | IDC | 1.14e-09 | 2.34e-01 | 0.1524 |
25824 | PRDX5 | GSM4909297 | Human | Breast | IDC | 4.42e-19 | -2.97e-01 | 0.1517 |
25824 | PRDX5 | GSM4909298 | Human | Breast | IDC | 1.70e-12 | -3.23e-01 | 0.1551 |
25824 | PRDX5 | GSM4909308 | Human | Breast | IDC | 4.98e-06 | 3.30e-01 | 0.158 |
25824 | PRDX5 | GSM4909311 | Human | Breast | IDC | 2.54e-44 | -3.99e-01 | 0.1534 |
25824 | PRDX5 | GSM4909312 | Human | Breast | IDC | 2.90e-10 | -2.38e-01 | 0.1552 |
25824 | PRDX5 | GSM4909319 | Human | Breast | IDC | 2.19e-57 | -1.90e-01 | 0.1563 |
25824 | PRDX5 | GSM4909320 | Human | Breast | IDC | 6.37e-04 | -2.06e-01 | 0.1575 |
25824 | PRDX5 | GSM4909321 | Human | Breast | IDC | 4.00e-14 | 6.88e-02 | 0.1559 |
25824 | PRDX5 | brca2 | Human | Breast | Precancer | 3.14e-03 | 2.47e-01 | -0.024 |
25824 | PRDX5 | M2 | Human | Breast | IDC | 1.59e-03 | 2.90e-01 | 0.21 |
25824 | PRDX5 | NCCBC14 | Human | Breast | DCIS | 4.31e-07 | -2.21e-01 | 0.2021 |
25824 | PRDX5 | NCCBC2 | Human | Breast | DCIS | 1.39e-02 | -5.48e-02 | 0.1554 |
25824 | PRDX5 | NCCBC5 | Human | Breast | DCIS | 4.46e-12 | -2.91e-01 | 0.2046 |
25824 | PRDX5 | P1 | Human | Breast | IDC | 1.80e-29 | -6.25e-01 | 0.1527 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:20001169 | Breast | Precancer | regulation of cysteine-type endopeptidase activity | 43/1080 | 235/18723 | 1.30e-11 | 1.83e-09 | 43 |
GO:00432819 | Breast | Precancer | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 40/1080 | 209/18723 | 1.59e-11 | 2.07e-09 | 40 |
GO:00621979 | Breast | Precancer | cellular response to chemical stress | 51/1080 | 337/18723 | 2.40e-10 | 2.34e-08 | 51 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00345999 | Breast | Precancer | cellular response to oxidative stress | 42/1080 | 288/18723 | 2.78e-08 | 1.79e-06 | 42 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:20001179 | Breast | Precancer | negative regulation of cysteine-type endopeptidase activity | 19/1080 | 86/18723 | 3.36e-07 | 1.58e-05 | 19 |
GO:00988698 | Breast | Precancer | cellular oxidant detoxification | 20/1080 | 101/18723 | 1.07e-06 | 4.18e-05 | 20 |
GO:00431548 | Breast | Precancer | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 17/1080 | 78/18723 | 1.69e-06 | 6.08e-05 | 17 |
GO:00454548 | Breast | Precancer | cell redox homeostasis | 11/1080 | 35/18723 | 2.59e-06 | 8.65e-05 | 11 |
GO:19907488 | Breast | Precancer | cellular detoxification | 21/1080 | 116/18723 | 2.67e-06 | 8.89e-05 | 21 |
GO:00987548 | Breast | Precancer | detoxification | 24/1080 | 152/18723 | 6.49e-06 | 1.81e-04 | 24 |
GO:00972378 | Breast | Precancer | cellular response to toxic substance | 21/1080 | 124/18723 | 7.98e-06 | 2.17e-04 | 21 |
GO:00346149 | Breast | Precancer | cellular response to reactive oxygen species | 23/1080 | 155/18723 | 2.82e-05 | 6.31e-04 | 23 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa041462 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa041463 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa041464 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa041465 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa041466 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414611 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414621 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
hsa0414631 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PRDX5 | PLA | Lung | Healthy | CYB5B,ERGIC3,NDUFC2, etc. | 6.88e-02 | ![]() |
PRDX5 | PLA | Skin | Healthy | ALOX5AP,SH3BGRL3,CYBA, etc. | 6.71e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRDX5 | SNV | Missense_Mutation | rs143723178 | c.166N>G | p.Ile56Val | p.I56V | P30044 | protein_coding | tolerated(0.24) | benign(0.009) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PRDX5 | SNV | Missense_Mutation | novel | c.154N>A | p.Ala52Thr | p.A52T | P30044 | protein_coding | tolerated(0.2) | benign(0.007) | TCGA-EY-A1GQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
PRDX5 | SNV | Missense_Mutation | novel | c.37G>A | p.Ala13Thr | p.A13T | P30044 | protein_coding | tolerated_low_confidence(0.24) | benign(0.001) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRDX5 | SNV | Missense_Mutation | c.496G>C | p.Asp166His | p.D166H | P30044 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
25824 | PRDX5 | ENZYME | 2-(2-HYDROXYBENZYL)PHENOL | CHEMBL148831 | 26492576 | |
25824 | PRDX5 | ENZYME | Diterpene triepoxide derivative 1 | |||
25824 | PRDX5 | ENZYME | Motexafin gadolinium |
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