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Gene: PQLC2 |
Gene summary for PQLC2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PQLC2 | Gene ID | 54896 |
Gene name | solute carrier family 66 member 1 | |
Gene Alias | LAAT-1 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | A0A024RA97 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54896 | PQLC2 | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 1.54e-01 | 0.0875 |
54896 | PQLC2 | P2T-E | Human | Esophagus | ESCC | 1.69e-16 | 2.75e-01 | 0.1177 |
54896 | PQLC2 | P4T-E | Human | Esophagus | ESCC | 6.14e-11 | 2.24e-01 | 0.1323 |
54896 | PQLC2 | P5T-E | Human | Esophagus | ESCC | 3.97e-04 | 9.61e-02 | 0.1327 |
54896 | PQLC2 | P8T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.71e-01 | 0.0889 |
54896 | PQLC2 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 1.58e-01 | 0.1131 |
54896 | PQLC2 | P10T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.80e-01 | 0.116 |
54896 | PQLC2 | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.55e-01 | 0.1426 |
54896 | PQLC2 | P12T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.61e-01 | 0.1122 |
54896 | PQLC2 | P15T-E | Human | Esophagus | ESCC | 2.31e-15 | 2.79e-01 | 0.1149 |
54896 | PQLC2 | P16T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.20e-01 | 0.1153 |
54896 | PQLC2 | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 2.27e-01 | 0.1278 |
54896 | PQLC2 | P19T-E | Human | Esophagus | ESCC | 2.24e-09 | 5.35e-01 | 0.1662 |
54896 | PQLC2 | P20T-E | Human | Esophagus | ESCC | 4.83e-12 | 2.69e-01 | 0.1124 |
54896 | PQLC2 | P21T-E | Human | Esophagus | ESCC | 2.25e-22 | 4.35e-01 | 0.1617 |
54896 | PQLC2 | P22T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.07e-01 | 0.1236 |
54896 | PQLC2 | P23T-E | Human | Esophagus | ESCC | 6.47e-17 | 3.58e-01 | 0.108 |
54896 | PQLC2 | P24T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.19e-01 | 0.1287 |
54896 | PQLC2 | P26T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.17e-01 | 0.1276 |
54896 | PQLC2 | P27T-E | Human | Esophagus | ESCC | 7.30e-09 | 2.33e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PQLC2 | SNV | Missense_Mutation | c.305C>T | p.Ala102Val | p.A102V | Q6ZP29 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PQLC2 | SNV | Missense_Mutation | c.832C>T | p.Arg278Cys | p.R278C | Q6ZP29 | protein_coding | deleterious(0.02) | benign(0.018) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PQLC2 | SNV | Missense_Mutation | novel | c.607A>G | p.Ile203Val | p.I203V | Q6ZP29 | protein_coding | deleterious(0.01) | possibly_damaging(0.883) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
PQLC2 | SNV | Missense_Mutation | c.832C>T | p.Arg278Cys | p.R278C | Q6ZP29 | protein_coding | deleterious(0.02) | benign(0.018) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PQLC2 | SNV | Missense_Mutation | rs766989390 | c.115G>A | p.Val39Met | p.V39M | Q6ZP29 | protein_coding | deleterious(0) | possibly_damaging(0.639) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PQLC2 | SNV | Missense_Mutation | novel | c.751C>T | p.His251Tyr | p.H251Y | Q6ZP29 | protein_coding | deleterious(0) | benign(0.122) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PQLC2 | SNV | Missense_Mutation | novel | c.562N>T | p.Gly188Cys | p.G188C | Q6ZP29 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PQLC2 | SNV | Missense_Mutation | novel | c.452N>A | p.Ala151Asp | p.A151D | Q6ZP29 | protein_coding | tolerated(0.61) | benign(0) | TCGA-D6-A6EQ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PQLC2 | SNV | Missense_Mutation | rs768403585 | c.625C>T | p.Arg209Trp | p.R209W | Q6ZP29 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-V1-A9ZK-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
PQLC2 | SNV | Missense_Mutation | c.781N>A | p.Gly261Ser | p.G261S | Q6ZP29 | protein_coding | deleterious(0.04) | probably_damaging(0.947) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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